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• CHNO-fuel substrate
  ...ess of [[cell respiration]]. Mitochondrial pathways are stimulated by CHNO-fuel substrates feeding electrons into the [[ETS]] at different levels of integr |mitopedia topic=Substrate and metabolite
  564 bytes (68 words) - 11:41, 3 April 2021

Page text matches

• CHNO-fuel substrate
  ...ess of [[cell respiration]]. Mitochondrial pathways are stimulated by CHNO-fuel substrates feeding electrons into the [[ETS]] at different levels of integr |mitopedia topic=Substrate and metabolite
  564 bytes (68 words) - 11:41, 3 April 2021
• Substrates as electron donors
  |description='''[[Substrate]]s as electron donors''' are reduced fuel compounds ''S''_red that are oxidized to an oxidized product ''P' |mitopedia topic=Substrate and metabolite
  847 bytes (119 words) - 19:00, 7 May 2023
• Lettieri-Barbato 2019 Mol Metab
  ...strate availability and the consequence of mitochondrial failure to switch fuel oxidation in response to changes in nutrient availability. A framework to c ...-sensitive thermogenic signaling cascade and UCP1. However, an overload of substrate flux to mitochondria causes a massive and damaging mitochondrial ROS produc
  2 KB (246 words) - 09:05, 16 September 2023
• Weibel 1996 J Exp Biol
  ...en and substrate pathways. VII. Different structural limits for oxygen and substrate supply to muscle mitochondria. J Exp Biol 199:1699-1709. design in partitioning and limiting substrate supply. The
  3 KB (391 words) - 18:02, 14 January 2014
• Rondot 2020 Thesis
  ...he fat body can be converted to the amino acid proline, and this metabolic fuel has recently been discovered to be readily oxidized by bumblebee workers. M |topics=Substrate, Temperature
  2 KB (294 words) - 16:54, 17 June 2020
• Glutamate-anaplerotic pathway control state
  ...state |NADH-linked type 4 substrate]] (N). When supplied as the sole fuel substrate in the '''glutamate-anaplerotic pathway control state''', G is transported LEAK state (''L'') with G alone as substrate can be evaluated in the following SUIT protocol:
  2 KB (276 words) - 20:11, 1 January 2021
• Xiao 2024 Sci Adv
  ...phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise. Sci Adv 10:eadj2752. https://doi.org/10.1126/s ...n muscle regulates mitochondrial electron transfer chain complex assembly, fuel utilization, and exercise performance without affecting mechanistic target
  2 KB (287 words) - 15:56, 6 March 2024
• Frangos 2023 J Biol Chem
  ...y be more susceptible to the effects of acidosis, possibly contributing to fuel shifts with increasing exercise intensity. |keywords=CPT-I, Mitochondrial bioenergetics, Exercise, Fuel metabolism, Lipid metabolism, pH, Skeletal muscle
  3 KB (361 words) - 17:19, 13 September 2023
• Thapa 2022 Physiol Rep
  ...HA1, allowing aged obese mice to continue using pyruvate as a bioenergetic substrate in the heart. Our findings suggest that changes in mitochondrial protein ly
  2 KB (307 words) - 14:45, 10 August 2022
• Komlodi 2018 AussieMit
  ...he Q redox state, H₂O₂ and O₂ fluxes with fuel substrates provided separately and in combination, thus varying the electro ...substrates in OXPHOS. Q was most reduced in LEAK with S50. Taken together, substrate combinations exerted an additive effect on H₂O₂ gener
  3 KB (517 words) - 18:56, 10 January 2022
• Weber 1987 Am J Physiol
  ...alian pattern, but this substrate only plays a minor role as an oxidizable fuel in horses. The oxidation of plasma lactate accounts for less than 5% of met
  2 KB (277 words) - 15:22, 28 October 2013
• Glycerophosphate pathway control state
  ...r-pathway state |ET-pathway level 3 control state]], supported by the fuel substrate [[glycerophosphate]] and electron transfer through [[glycerophosphate dehyd ...paratively low in human vastus lateralis. Glycerophosphate is an important substrate for respiration in brown adipose tissue mitochondria.
  2 KB (207 words) - 19:28, 25 August 2023
• Darveau 2013 Abstract MiP2013
  ...ers, we investigated the diversity and evolution of proline as a metabolic fuel in bees and wasps. I will show how the honeybee is not representative of hy |topics=Substrate
  3 KB (383 words) - 11:10, 28 April 2017
• Proline
  ...glutamate-anaplerotic pathway control state]]. Proline is used as a single substrate or in combination with carbohydrate-derived metabolites in mitochondria par :::# Teulier L, Weber JM, Crevier J, Darveau CA (2016) Proline as a fuel for insect flight: enhancing carbohydrate oxidation in hymenopterans. Proc
  2 KB (269 words) - 09:44, 11 September 2020
• Reference state
  ...[[metabolic control variable]] ''X''. If ''X'' stimulates flux (ADP, fuel substrate), it is present in the reference state but absent in the background state.
  1 KB (179 words) - 18:14, 10 November 2020
• Schreiber 2017 Cell Metab
  ...y severe cardiomyopathy. We conclude that functional NST requires adequate substrate supply and cardiac function, but does not depend on ATGL-mediated lipolysis
  2 KB (275 words) - 12:27, 29 May 2018
• Cortassa 2019 Front Physiol
  |title=Cortassa S, Aon MA, Sollott SJ (2019) Control and regulation of substrate selection in cytoplasmic and mitochondrial catabolic networks. A systems bi ...abolism is highly distributed across the metabolic network suggesting that fuel selection between FAs and Glc goes well beyond the mechanisms traditionally
  3 KB (448 words) - 05:42, 26 October 2023
• McClelland 1998 Proc Natl Acad Sci U S A
  ...and (ii) relative exercise intensity is the major determinant of metabolic fuel selection at HA, as well as at SL. |topics=Coupling efficiency;uncoupling, Substrate
  2 KB (302 words) - 14:16, 16 June 2015
• Henriques 2013 Thesis Universidade de Coimbra - Portugal
  ...ate. These results suggest that hippocampal cells readily use lactate as a substrate of oxidative metabolism and that even in the situation of increased neurona
  3 KB (357 words) - 14:35, 13 November 2017
• Wensaas 2007 J Lipid Res
  ...revon CA, Hallén S (2007) Cell-based multiwell assays for the detection of substrate accumulation and oxidation. J Lipid Res 48:961-7. ...easy-to-use and time- saving methods for ''in vitro'' studies of cellular fuel handling.
  2 KB (250 words) - 16:18, 27 March 2018
• Gnaiger 2018 MiP2018
  ...r Erich.jpg|90px|left|Erich Gnaiger]] Mitochondrial respiratory control by fuel substrates and specific inhibitors of respiratory enzymes: Building blocks ...ture I aim at providing (''1'') a historical account of the development of substrate-uncoupler-inhibitor-titration (SUIT) protocols to address defined PCS, as a
  6 KB (827 words) - 11:51, 3 November 2018
• Kamath 2010
  ..., Krieglstein J, Kowluru A. (2010) Regulation of glucose-and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in p ...on, additional studies are needed to precisely identify the phosphoprotein substrate(s) for PHP in the cascade of events leading to nutrient-induced insulin sec
  2 KB (317 words) - 10:51, 21 November 2012
• Kamath 2010 Am J Physiol Endocrinol Metab
  ..., Krieglstein J, Kowluru A (2010) Regulation of glucose- and mitochondrial fuel-induced insulin secretion by a cytosolic protein histidine phosphatase in p ...on, additional studies are needed to precisely identify the phosphoprotein substrate(s) for PHP in the cascade of events leading to nutrient-induced insulin sec
  2 KB (341 words) - 15:08, 26 May 2015
• Gnaiger 2017 Abstract EUROMIT2017 Cologne
  ...a compensatory or adaptive metabolic reprogramming and shift of preferred substrate utilization. Combining the flexibility of cell culture models and tissue sa
  4 KB (491 words) - 19:17, 10 January 2022
• Forbes 2018 Nat Rev Nephrol
  ...ors including mutations in genes that impact mitochondrial function and/or substrate delivery may also be important risk factors for DKD. Hence, we postulate th
  2 KB (247 words) - 20:08, 14 September 2023
• Q-pools
  ...ne in aerobic [[mitochondrial preparations]] incubated without [[CHNO-fuel substrate]]s. Intermediate redox states of Q_ra are sensitive to pathway co ...ia and partially reduced in aerobic mt-preparations incubated without CHNO-fuel substrates || || 1, 2, 3
  5 KB (698 words) - 21:19, 3 April 2021
• Sumbalova 2014 Abstract MiP2014
  ...n multiple types of mitochondria revealed that malate, a substrate used to fuel CI-linked respiration, inhibits CII-linked (succinate+rotenone; coupled and ...be suggestive of a higher involvement of SDH in respiration with CI-linked substrate combinations. Indeed, this involvement, as determined by inhibition of SDH
  4 KB (587 words) - 13:46, 5 January 2023
• Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT
  ...easured using high-resolution respirometry (O2k, Oroboros Instruments) and substrate-uncoupler-inhibitor titration (SUIT) protocols developed specifically for t ...s a central role in the maintenance of mitochondrial respiration as a fuel substrate.
  4 KB (479 words) - 18:55, 10 January 2022
• Coupling/pathway control diagram
  ...a transition is induced between two [[coupling-control state]]s. If ''X'' (fuel substrates, e.g. pyruvate and succinate, or [[Electron transfer pathway]] i
  2 KB (240 words) - 20:03, 1 January 2021
• Alan 2023 MiP2023
  ...lebrand Domain-containing Protein 8 (Vwa8) in mitochondrial morphology and substrate preference. ...th the organization of membrane protein complexes as well as mitochondrial substrate preference1. <br>
  3 KB (437 words) - 16:44, 12 July 2023
• Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT
  ...red using High-Resolution FluoRespirometry (O2k, Oroboros Instruments) and substrate-uncoupler-inhibitor titration (SUIT) protocols developed specifically for t ...s a central role in the maintenance of mitochondrial respiration as a fuel substrate.
  3 KB (465 words) - 19:11, 10 January 2022
• Rustan 2017 Abstract MITOEAGLE Barcelona
  ...s of the myotubes, and how these processes can be measured using efficient fuel handling systems. ...ous or subsequent capture of the ¹⁴CO₂ produced. The substrate oxidation assay is a novel variant of previously described experimental app
  4 KB (536 words) - 14:31, 12 January 2018
• Lin 2017 FASEB J
  ...high-resolution respirometry Oroboros Oxygraph-2k (O2k). The mitochondrial substrate-uncoupler-inhibitor titration (SUIT) protocol was used to determine mitocho ...cific mitochondrial respiration is likely associated with the differential fuel metabolism and contractile properties of muscle fibers.
  3 KB (361 words) - 17:32, 25 February 2020
• Hand 2012 Abstract Bioblast
  ...ence of a diffusible inhibitor. Similar patterns are seen with Complex II substrate alone (succinate), which supports a much higher OXPHOS capacity than that o
  5 KB (683 words) - 11:16, 8 June 2020
• Zhang 2020 Intensive Care Med Exp
  ...anz C, Hellmann A, Mizaikoff B, Radermacher P, Hartmann C (2020) Metabolic substrate utilization in stress-induced immune cells. Intensive Care Med Exp 8:28. ...rom glucose, other sources, such as fatty acids and glutamine, are able to fuel the TCA cycle. Rising evidence has shown that cellular metabolism has a dir
  2 KB (281 words) - 14:40, 19 January 2021
• Categories of SUIT protocols
  ...IT protocols''' group [[MitoPedia: SUIT |SUIT protocols]] according to all substrate types involved in a protocol (F, N, S, Gp), independent of the sequence of ...tocol, the categories of SUIT protocols reduce this diversity to a list of substrate types involved.
  5 KB (673 words) - 16:25, 3 June 2020
• Electron-transfer-pathway state
  ...ogenous substrates and addition to the mitochondrial respiration medium of fuel substrates (CHNO) activating specific mitochondrial pathways, and possibly ...mitochondrial [[SUIT protocols]]. Mitochondrial pathways are stimulated by fuel substrates (CHNO) feeding electrons into the [[Electron transfer pathway]]
  15 KB (1,913 words) - 19:27, 25 August 2023
• SUIT-003 O2 ce-pce D018
  ...d, the addition of [[pyruvate]] is recommended to provide an external fuel substrate.
  2 KB (309 words) - 23:56, 12 April 2021
• Bastos Sant'Anna Silva 2018 MiPschool Tromso C4
  ...easured using high-resolution respirometry (O2k, Oroboros Instruments) and substrate-uncoupler-inhibitor titration (SUIT) protocols developed specifically for t ...s a central role in the maintenance of mitochondrial respiration as a fuel substrate.
  5 KB (637 words) - 19:10, 10 January 2022
• Schulte 1992 J Exp Biol
  ...s may limit the rate at which white muscle mitochondria can produce ATP to fuel glycogenesis in situ. It is postulated that the high [ATP]/[ADP]f ratios ar |topics=Aerobic glycolysis, ADP, ATP, AMP, PCr;Cr, pH, Phosphate, Substrate
  2 KB (309 words) - 09:13, 9 November 2016
• George 2015 BA Thesis
  ...rch continually demonstrates that lactate serves as an important metabolic fuel for many tissues, including skeletal and cardiac muscles, liver and brain. |topics=Substrate
  3 KB (336 words) - 16:41, 7 November 2016
• Lagoutte 2010 Biochim Biophys Acta
  ...he mitochondrial complex I. This explains why the oxidation of the mineral substrate sulfide takes precedence over the oxidation of other (carbon-based) mitocho
  2 KB (343 words) - 13:30, 13 November 2017
• Rocha 2018 J Physiol Biochem
  ...further support the notion that cardiomyocytes prefer lipids as a primary fuel source, by demonstrating that the shift in metabolism caused by a LCHF diet
  2 KB (312 words) - 13:21, 17 April 2019
• Schoepf 2018 33rd Annual EAU Congress Copenhagen
  substrate/uncoupler/inhibitor titration protocol (Schöpf et al. FEBS J, 2016, doi: 1 reduced respiratory capacity with glutamate as a fuel substrate accompanied by a preferred utilization of pyruvate and succinate in maligna
  3 KB (467 words) - 13:00, 23 March 2018
• Lantier 2015 Diabetes
  ...is decreased while fatty acid-based respiration is increased, reflecting a fuel switch from glucose to fatty acids. Consistent with reduced muscle glucose
  2 KB (328 words) - 09:09, 8 November 2016
• Zhunussova 2015 Am J Cancer Res
  ...ment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res 5:1665-79. |topics=pH, Substrate
  3 KB (353 words) - 16:11, 20 April 2021
• Juellig 2008 Proteomics
  ...sta S, Choong SY, Philips AR, Cooper GJ (2008) Is the failing heart out of fuel or a worn engine running rich? A study of mitochondria in old spontaneously ...s to HF. Although the hypertensive failing heart generally shows increased substrate preference towards glucose and impaired mitochondrial function, the cause-a
  2 KB (327 words) - 14:10, 27 March 2015
• Kane 2014 Abstract MiP2014
  ...ochrome ''c'' stimulates respiration with lactate but not with pyruvate as substrate. |topics=Aerobic glycolysis, ATP production, Cyt c, Redox state, Substrate
  4 KB (506 words) - 16:27, 4 March 2015
• Patil 2024 J Exp Biol
  ...nsfer (ET capacity, ''E'') through respiratory Complex I or the Complex II substrate succinate are used. When pyruvate, malate and succinate are combined, respi
  3 KB (354 words) - 23:46, 17 April 2024
• Sumbalova 2016a Abstract MitoFit Science Camp 2016
  ...pe investigated, reflecting tissue-specific enzyme expression patterns and substrate preferences. ...ltiple types of mitochondria revealed that malate (M), a substrate used to fuel CI-linked respiration, inhibits both coupled and uncoupled CII-linked respi
  7 KB (1,014 words) - 19:16, 10 January 2022