Test - Ecosystem agenda: Difference between revisions

Revision as of 11:00, 30 November 2020

Test - Ecosystem agenda

O2k-Publications alert

Mitochondria and Cell Research - the Oroboros Ecosystem

» Listed in Oroboros Ecosystem Agenda 2020 Archive

Dec 2020

Dec-22 Tu

Impaired mitochondrial respiration in platelets: A future biomarker for Alzheimer’s disease?

from the O2k-Network »CZ Prague Fisar Z«

Fišar Z, Jirák R, Zvěřová M, Setnička V, Habartová L, Hroudová J, Vaníčková Z, Raboch J (2019) Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease. Clin Biochem 72:71-80. »Bioblast link«

Dec-15 Tu

Mitotherapy: A promising therapeutic approach for central nervous system damage?

from the O2k-Network »BR Rio de Janeiro Galina A« and »BR Rio de Janeiro Institute Biomedical Chemistry«

Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686. »Bioblast link«

Dec-08 Tu

Is the mitochondrial uncoupler BAM15 the new anti-obesity drug?

from the O2k-Network »AU Sydney Philp A«

Alexopoulos SJ, Chen SY, Brandon AE, Salamoun JM, Byrne FL, Garcia CJ, Beretta M, Olzomer EM, Shah DP, Philp AM, Hargett SR, Lawrence RT, Lee B, Sligar J, Carrive P, Tucker SP, Philp A, Lackner C, Turner N, Cooney GJ, Santos WL, Hoehn KL (2020) Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nat Commun 11:2397. »Bioblast link«

Nov 2020

Dec-02 We

Antioxidant supplementation: Effects of MitoQ and CoQ10 on ROS production and mitochondrial function

from the O2k-Network »NZ Auckland Hickey AJ«

Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69. »Bioblast link«

Nov-27 Fr

HSP60 knockdown and its effect on mitochondria’s role in pancreatic ductal adenocarcinoma

Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161. »Bioblast link«

Nov-25 We

Eight-week high-fat feeding increases mitochondrial ROS production in white adipocytes but mitochondrial respiration remains unaffected.

from the O2k-Network »CA Guelph Holloway GP«

Politis-Barber V, Brunetta HS, Paglialunga S, Petrick HL, Holloway GP (2020) Long-term high-fat feeding exacerbates short-term increases in adipose mitochondrial reactive oxygen species, without impairing mitochondrial respiration. Am J Physiol Endocrinol Metab 319:E376-87. »Bioblast link«

Nov-16 Mo

Mitochondrial function is impaired in human iPSC-derived astrocytes infected with Zika virus.

from the O2k-Network »BR Rio de Janeiro Galina A« and »BR Rio de Janeiro Institute Biomedical Chemistry«

Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218. »Bioblast link«

Nov-14 Sa - World Diabetes Day

Gastric bypass surgery improves diabetic nephropathy by reducing NADPH production via restoration of AMPK activity in type 1 diabetic rats

from the O2k-Network »CN Chongqing Zhu Z«

Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207. »Bioblast link«

Nov-04 We

Six-month caloric restriction causes tissue-specific bioenergetic changes in mitochondria isolated from rat heart and skeletal muscle

from the O2k-Network »BR Sao Paulo Kowaltowski AJ«

Serna JDC, Caldeira da Silva CC, Kowaltowski AJ (2020) Functional changes induced by caloric restriction in cardiac and skeletal muscle mitochondria. J Bioenerg Biomembr 52:269-77.»Bioblast link«

Oct 2020

Oct-30 Fr

Measuring ATP-ADP exchange via adenine nucleotide translocase (ANT) using the fluorophore Magnesium Green (MgG)

from the O2k-Network »HU Budapest Chinopoulos C«

Chinopoulos C, Kiss G, Kawamata H, Starkov AA (2014) Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption. Methods Enzymol 542:333-48. »Bioblast link«

Oct-23 Fr

Simultaneous measurement of O₂ flux and mt-membrane potential: A method to detect deficiency in mitochondrial electron transfer system

from the O2k-Network »AT Innsbruck Oroboros« and »AT Innsbruck Gnaiger E«

Krumschnabel G, Eigentler A, Fasching M, Gnaiger E (2014) Use of safranin for the assessment of mitochondrial membrane potential by high-resolution respirometry and fluorometry. Methods Enzymol 542:163-81. »Bioblast link«

Oct-21 We

Blood cell respirometry might be an attractive alternative to skeletal- and cardiac muscle-based assessment of mitochondrial function in human studies

from the O2k-Network »US NC Winston-Salem Molina AJA«

Tyrrell DJ, Bharadwaj MS, Jorgensen MJ, Register TC, Molina AJ (2016) Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox Biol 10:65-77.»Bioblast link«

Oct-14 We

Calcium overload: The mechanism by which ER stress leads to Complex I dysfunction?

from the O2k-Network »US VA Richmond Lesnefsky EJ«

Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced Complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299. »Bioblast link«

Oct-08 Th

Childhood maltreatment is associated with increased mitochondrial bioenergetic function of immune cells in mothers, but not in their newborns

from the O2k-Network »DE Ulm Gumpp A«

Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84. »Bioblast link«

Oct-06 Tu

Fasting promotes functional changes in liver mitochondria: Is it time to reconsider using fasted animals for liver mitochondria isolation?

from the O2k-Network »BR Sao Paulo Kowaltowski AJ«

Menezes-Filho SL, Amigo I, Luévano-Martínez LA, Kowaltowski AJ (2018) Fasting promotes functional changes in liver mitochondria. Biochim Biophys Acta Bioenerg 1860:129-35. »Bioblast link«

Sep 2020

Sep-29 Tu - World Heart Day

Succinate dehydrogenase inhibition protects myocardium from ischemia reperfusion injury but efficacy may be influenced by diabetes

from the O2k-Network »DK Aarhus Boetker HE« and »DK Copenhagen Larsen S«

Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344. »Bioblast link«

Sep-21 Mo - World Alzheimer's Day

Olive polyphenols prove promising in the protection against mitochondrial dysfunction due to Alzheimer's disease and brain aging

from the O2k-Network »DE Giessen Eckert GP«

Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. »Bioblast link«

Resistance training effects in Alzheimer’s disease mouse model

from the O2k-Network »US FL Boca Raton Khamoui AV«

Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501. »Bioblast link«

Sep-15 Tu - World Lymphoma Awareness Day

OXPHOS as a potential therapeutic target in classical Hodgkin lymphoma

from the O2k-Network »DE Frankfurt Droese S«, »DE Frankfurt Wittig I« and »NL Nijmegen Brandt U«

Birkenmeier K, Droese S, Wittig I, Winkelmann R, Käfer V, Doering C, Hartmann S, Wenz T, Reichert AS, Brandt U, Hansmann ML (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46. »Bioblast link«

Sep-08 Tu

Alternative oxidase (AOX) can prevent acute hypoxic pulmonary vasoconstriction in mouse lung

from the O2k-Network »DE Giessen Weissmann N«, »FI Tampere Dufour E«, »FI Helsinki Jacobs HT« and »DE Jena Szibor M«

Sommer N, Alebrahimdehkordi N, Pak O, Knoepp F, Strielkov I, Scheibe S, Dufour E, Andjelekovic A, Sydykov A, Saraji A, Petrovic A, Quanz K, Hecker M, Kumar M, Wahl J, Kraut S, Seeger W, Schermuly RT, Ghofrani HA, Ramser K, Braun T, Jacobs HT, Weissmann N, Szibor M (2020) Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing. Sci Adv 6:eaba0694. »Bioblast link«

Sep-01 Tu

A cell-permeable succinate prodrug can alleviate N-methyl carbamate-induced Complex I dysfunction

from the O2k-Network »US PA Philadelphia Kilbaugh T«, »US PA Philadelphia Jang DH« and »SE Lund Elmer E«

Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK (2020) Mitochondrial respiratory chain Complex I dysfunction induced by N-methyl carbamate ex vivo can be alleviated with a cell-permeable succinate prodrug carbamate toxicity and treatment. Toxicol In Vitro 65:104794. »Bioblast link«

Aug 2020

Aug-25 Tu

Low-intensity exercise increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

from the O2k-Network »LV Riga Makrecka-Kuka M«

Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489. »Bioblast link«

Aug-18 Tu

Mitochondrial respiration in PBMCs from patients with major depression

from the O2k-Network »DE Ulm Karabatsiakis A« and »DE Ulm Radermacher P«

Karabatsiakis A, Boeck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, Kolassa IT (2014) Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry 4:e397. »Bioblast link«

Aug-14 Fr

Mitochondrial respiration in PBMCs: a potential parameter to monitor acute pancreatitis

from the O2k-Network »NZ Auckland Hickey AJ«

Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47. »Bioblast link«

Aug-11 Tu

Ocean warming affects mitochondrial ET capacity in developing eggs of Atlantic herring

from the O2k-Network »DE Bremerhaven Mark FC«

Leo E, Dahlke FT, Storch D, Poertner HO, Mark FC (2018) Impact of Ocean Acidification and Warming on the bioenergetics of developing eggs of Atlantic herring Clupea harengus. Conserv Physiol 6:coy050. »Bioblast link«

Aug-04 Tu

Liver-specific deletion of PARKIN impairs the mitochondrial phosphorylation system

from the O2k-Network »US PA Pittsburgh Jurczak MJ«

Edmunds LR, Xie B, Mills AM, Huckestein BR, Undamatla R, Murali A, Pangburn MM, Martin J, Sipula I, Kaufman BA, Scott I, Jurczak MJ (2020) Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance. Mol Metab [Epub ahead of print]. »Bioblast link«

Jul 2020

Jul-28 Tu - World Hepatitis Day

Hepatitis C virus protein expression is related to changes in mitochondrial respiration

from the O2k-Network »IT Foggia Capitanio N«

Ripoli M, D'Aprile A, Quarato G, Sarasin-Filipowicz M, Gouttenoire J, Scrima R, Cela O, Boffoli D, Heim MH, Moradpour D, Capitanio N, Piccoli C (2009) Hepatitis C virus-linked mitochondrial dysfunction promotes hypoxia-inducible factor 1α-mediated glycolytic adaptation. J Virol 84:647-60. »Bioblast link«

Jul-21 Tu

Absence of AMPK in skeletal muscle impacts mitochondrial content and respiration in addition to mitigating glucose intolerance induced by a high-fat diet

from the O2k-Network »US TN Nashville Wasserman DH« and »US MN Minneapolis Hughey C«

Lantier L, Williams AS, Williams IM, Guerin A, Bracy DP, Goelzer M, Foretz M, Viollet B, Hughey CC, Wasserman DH (2020) Reciprocity between skeletal muscle AMPK deletion and insulin action in diet-induced obese mice. Diabetes [Epub ahead of print]. »Bioblast link«

Jul-14 Tu

Alternative oxidase inhibition plays a key role in the aluminum tolerance of cultured Jatropha curcas cells

from the O2k-Network »BR Ribeirao Preto Alberici LC«

Vicentini TM, Cavalheiro AH, Dechandt CRP, Alberici LC, Vargas-Rechia CG (2019) Aluminum directly inhibits alternative oxidase pathway and changes metabolic and redox parameters on Jatropha curcas cell culture. Plant Physiol Biochem 136:92-97. »Bioblast link«

Jul-07 Tu

Influenza A infection induces persistent alterations in whole-body glucose metabolism in mice

from the O2k-Network »FR Lille Duez H«

Ayari A, Rosa-Calatrava M, Lancel S, Barthelemy J, Pizzorno A, Mayeuf-Louchart A, Baron M, Hot D, Deruyter L, Soulard D, Julien T, Faveeuw C, Molendi-Coste O, Dombrowicz D, Sedano L, Sencio V, Le Goffic R, Trottein F, Wolowczuk I (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237. »Bioblast link«

Jul-03 Fr

Mitochondrial H₂O₂ flux in cardiac and skeletal muscle preparations is influenced by experimental oxygen concentration

from the O2k-Network »US CO Fort Collins Chicco AJ«

Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:R972-80. »Bioblast link«

Jun 2020

Jun-02 Tu

Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers

from the O2k-Network »AT Innsbruck Gnaiger E« , »CA Rimouski Blier PU« and »CA Edmonton Lemieux H«

Lemieux H, Blier PU, Gnaiger E (2017) Remodeling pathway control of mitochondrial respiratory capacity by temperature in mouse heart: electron flow through the Q-junction in permeabilized fibers. Sci Rep 7:2840. »Bioblast link«

Jun-12 Fr

Oxygen consumption by intact platelets positively correlates with the concentration of CoQ10 in the platelets of CKD patients

from the O2k-Network » SK Bratislava Sumbalova Z «

Gvozdjáková A, Sumbalová Z, Kucharská J, Komlósi M, Rausová Z, Vančová O, Számošová M, Mojto V (2020) Platelet mitochondrial respiration, endogenous coenzyme Q10 and oxidative stress in patients with chronic kidney disease. Diagnostics (Basel) 10:E176. »Bioblast link«

Jun-16 Tu

A new potential anti-aging therapeutic target: circadian regulation of mitochondrial uncoupling

from the O2k-Network »CA Montreal Hepple RT«

Ulgherait M, Chen A, McAllister SF, Kim HX, Delventhal R, Wayne CR, Garcia CJ, Recinos Y, Oliva M, Canman JC, Picard M, Owusu-Ansah E, Shirasu-Hiza M (2020) Circadian regulation of mitochondrial uncoupling and lifespan. Nat Commun 11:1927. »Bioblast link«

Jun-23 Tu

ASCs-exosomes: a potential therapy to restore mitochondrial function in amyotrophic lateral sclerosis

from the O2k-Network »IT Verona Calabria E«

Calabria E, Scambi I, Bonafede R, Schiaffino L, Peroni D, Potrich V, Capelli C, Schena F, Mariotti R (2019) ASCs-exosomes recover coupling efficiency and mitochondrial membrane potential in an in vitro model of ALS. Front Neurosci 13:1070. »Bioblast link«

Jun-30 Tu

The antidiabetic drug empagliflozin protects cardiac mitochondria against high-fat diet-induced dysfunction in mice

from the O2k-Network »LV Riga Makrecka-Kuka M«

Makrecka-Kuka M, Korzh S, Videja M, Vilks K, Cirule H, Kuka J, Dambrova M, Liepinsh E (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print]. »Bioblast link«

May 2020

May-29 Fr

F₁F_O-ATP synthase regulates alternative oxidase in Trypanosoma brucei

from the O2k-Network »BR Sao Paulo Silber AM«

Alberto Luévano-Martínez L, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print]. »Bioblast link«

May-26 Tu

Remodeling of OXPHOS in prostate cancer to potentially damaging mtDNA mutations and differential expression of mt-genes

from the O2k-Network »AT Innsbruck Gnaiger E« and »AT Innsbruck Oroboros«

Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Giese I, Sorn P, Sant’Anna-Silva AC, Iglesias-Gonzalez J, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487. »Bioblast link«

May-19 Tu

Allergic rhinitis induces mitochondrial dysfunction in peripheral blood cells«

from the O2k-Network »Charles Anne-Laure« »Geny Bernard«

Qi S, Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, de Blay F and Geny Bernard
(2017) Nasal allergen challenge in allergic rhinitis induces mitochondrial dysfunction of peripheral blood mononuclear cells. Ann Allergy Asthma Immunol 10.1016/j.anai.2016.11.026. »Bioblast link«

May-17 Su World Hypertension Day

Mitochondrial DNA enhances the hypoxia-induced cardioprotective effect in hypertensive rats

from the O2k-Network »CZ Prague Houstek J« and »CZ Prague Kalous M«

Neckar J, Svatonova A, Weissova R, Drahota Z, Zajickova P, Brabcova I, Kolar D, Alanova P, Vasinova J, Silhavy J, Hlavackova M, Tauchmannova K, Milerova M, Ostadal B, Cervenka L, Zurmanova J, Kalous M, Novakova O, Novotny J, Pravenec M, Kolar F (2017) Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats. Clin Sci (Lond) 131(9):865-881. »Bioblast link«

May-15 Fr

Restoration of mitochondrial oxygen consumption and decrease of mitochondrial ROS by AOX in the post-ischaemic heart are not sufficient to confer acute or chronic cardioprotection in mouse

from the O2k-Network » FI Helsinki Jacobs HT« , »DE Magdeburg Gellerich FN« , »FI Tampere Dufour E« , »DE Magdeburg Debska-Vielhaber G« and »DE Frankfurt Wittig I«

Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich Frank N, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48. »Bioblast link«

May-12 Tu

Mitochondria - a driving force in adipocyte differentiation

from the O2k-Network »CZ Pilsen Kuncova J«

Kladnická I, Čedíková M, Kripnerová M, Dvořáková J, Kohoutová M, Tůma Z, Müllerová D, Kuncová J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96. »Bioblast link«

May-05 Tu

Expression of alternative oxidase prevents reverse electron transfer formation in heart mitochondria isolated from mouse

from the O2k-Network »FI Helsinki Jacobs HT« »DE Magdeburg Gellerich FN« »FI Tampere Dufour E« »DE Magdeburg Debska-Vielhaber G« »DE Frankfurt Wittig I« and »UK Brighton Moore AL«

Szibor M, Gainutdinov T, Fernandez-Vizarra E, Dufour E, Gizatullina Z, Debska-Vielhaber G, Heidler J, Wittig I, Viscomi C, Gellerich FN, Moore AL (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137. »Bioblast link«

Apr 2020

Apr-28 Tu

The mitochondrial gas pedal: Cytosolic calcium controls extramitochondrial pyruvate generation and mitochondrial pyruvate uptake

from the O2k-Network » FI Helsinki Jacobs HT « » DE Magdeburg Gellerich FN « and »DE Magdeburg Debska-Vielhaber G«

Szibor Marten, Gizatullina Zemfira, Gainutdinov Timur, Endres Thomas, Debska-Vielhaber Grazyna, Kunz Matthias, Karavasili Niki, Hallmann Kerstin, Schreiber Frank, Bamberger Alexandra, Schwarzer Michael, Doenst Torsten, Heinze Hans-Jochen, Leßmann Volkmar, Vielhaber Stefan, Kunz Wolfram S, Gellerich Frank Norbert (2020) Cytosolic, but not matrix, calcium is essential for adjustment of mitochondrial pyruvate supply. J Biol Chem [Epub ahead of print]. »Bioblast link«

Apr-20 Mo

The effect of respiration buffer composition on mitochondrial metabolism and function

from the O2k-Network »US TN Nashville Wasserman DH« and »US MI East Lansing Bazil JN«

Wollenman LC, Vander Ploeg MR, Miller ML, Zhang Y, Bazil JN (2017) The effect of respiration buffer composition on mitochondrial metabolism and function. PLOS ONE 12:e0187523. - »Bioblast link«

Apr-15 Mo

Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies

from the O2k-Network »UY Montevideo Radi R«

García-Roche M, Casal A, Carriquiry M, Radi R, Celia Quijano C, Cassina A (2018) Respiratory analysis of coupled mitochondria in cryopreserved liver biopsies. Redox Biol 17:207-12. - »Bioblast link«

Apr-06 Mo

Physical activity has positive effects on mitochondria from patients with occupational burnout

from the O2k-Network »CH Basel Eckert A«

Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout - an interventional pilot study. J Clin Med 9:E667. - »Bioblast link«

Apr-03 Fr

Novel diurnal action of of mitochondrial stress-induced GDF15 in systemic metabolism regulation

from the O2k-Network »DE Nuthetal Klaus S«

Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep [Epub ahead of print]. - »Bioblast link«

Apr-01 We

Parkinson’s Disease Awareness Month: Dominant mutation in Parkinson’s Disease causes loss of protein function in mitochondria

from the O2k-Network »FR Angers Gueguen N« and »BE Leuven Spinazzi M«

Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet [Epub ahead of print]. »Bioblast link«

Mar 2020

Mar-20 Fr

High-resolution respirometry in human prostate cancer biopsies and mtDNA analyzed in samples recovered from the O2k-chamber

from the O2k-Network »AT Innsbruck Oroboros«

Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 2020-03-20 [Epub ahead of print]. - »Bioblast link«

Mar-12 Th

Multiple Sclerosis Month: Mitochondrial permeability transition pore protection as novel therapeutic approach in multiple sclerosis

from the O2k-Network »UK London Duchen MR«

Warne J, Pryce G, Hill J, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AW, Towers GJ, Coker A, Duchen MR, Szabadkai G, Baker D, Selwood D (2015) Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. J Biol Chem 291:4356-73. - »Bioblast link«

Mar-10 Tu

Muscular exercise for training adipose tissue mitochondria

from the O2k-Network »DK Copenhagen Larsen S«

Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785. - »Bioblast link«

Mar-09 Mo

Protein-specific mitochondrial respiratory capacity is higher in women than men

from the O2k-Network »SE Stockholm Cardinale DA«

Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133. - »Bioblast link«

Mar-04 We

Systemic mitochondrial bioenergetics in older adults - skeletal muscle and platelets

from the O2k-Network »US FL Orlando Goodpaster BH«

Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248. - »Bioblast link«

Mar-03 Tu

Rapamycin suppresses senescence in galactose versus glucose cell culture

from the O2k-Network »US PA Philadelphia Orynbayeva Z«

Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56. - »Bioblast link«

Mar-02 Mo

Salty diet, cardiac hypertrophy, calcium overload, and mitochondrial dysfunction

from the O2k-Network »CN Chongqing Zhu Z«

Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52. - »Bioblast link«

Feb 2020

Feb-27 Th

Regulation of mitochondrial oxygen kinetics by cytochrome c oxidase

from the O2k-Network »CZ Prague Houstek J«

Pajuelo-Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443. - »Bioblast link«

Feb-25 Tu

An active lifestyle protects cardiac mitochondria

from the O2k-Network »KR Busan Han J« - »KR Incheon Kwak HB«

No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. - »Bioblast link«

Feb-18 Tu

Aging and hyperlipidemia impair aortic mitochondrial function and increase the risk of atherosclerosis

from the O2k-Network »US MI Ann Arbor Beard DA«

Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314. - »Bioblast link«

Feb-05 We

Aerobic and resistance training address central defects and peripheral comorbidities in Alzheimer’s disease

from the O2k-Network »US FL Boca Raton Khamoui AV«

Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Diseases 2020:Article ID 5919501. - »Bioblast link«

Feb-03 Mo

Blood cell mitochondrial function does not provide a general substitute for muscle biopsies

from the O2k-Network »US AR Little Rock Boersheim E«

Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Boersheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. - »Bioblast link«

Jan 2020

Jan-28 Tu

Mitochondrial respiration of blood cells and cardiovascular disease

from the O2k-Network »FR Strasbourg Zoll J«

Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B (2020) Peripheral blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. - »Bioblast link«

Jan-18 Sa

Mitochondrial respiration is oxygen-dependent in human cardiac homogenate preparations

from the O2k-Network »CZ Prague Krajcova A«

Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. - »Bioblast link«

Jan-17 Fr

HRR - high-resolution respirometry and oxygen kinetics 10 years ago: Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 2010.

»Bioblast link«

Jan-15 We

Statistical evaluation on replica in HRR with permeabilized skeletal muscle fibers

from the O2k-Network »AU Melbourne Stepto NK«

Jacques M, Kuang J, Bishop DJ, Yan X, Alvarez-Romero J, Munson F, Garnham A, Papadimitriou I, Voisin S, Eynon N (2019) Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study. FASEB J 34:2978-86. - »Bioblast link«

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	Year	Reference
Pena 2020 Int J Chronic Dis	2020	Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Dis 2020:Article ID 5919501.
Krajcova 2020 PLOS ONE	2020	Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. https://doi.org/10.1371/journal.pone.0226142
Ost 2020 EMBO Rep	2020	Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804.
No 2020 Pflugers Arch	2020	No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93.
Pajuelo-Reguera 2020 Cells	2020	Pajuelo Reguera David, Čunátová Kristýna, Vrbacký Marek, Pecinová Alena, Houštěk Josef, Mráček Tomáš, Pecina Petr (2020) Cytochrome c oxidase subunit 4 isoform exchange results in modulation of oxygen affinity. Cells 9:E443.
Cornelissen 2020 Hum Mol Genet	2020	Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.
Alfatni 2020 J Clin Med	2020	Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B (2020) Peripheral blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311.
Mendham 2020 Sci Rep	2020	Mendham Amy E, Larsen Steen, George Cindy, Adams Kevin, Hauksson Jon, Olsson Tommy, Fortuin-de Smidt Melony C, Nono Nankam Pamela A, Hakim Olah, Goff Louise M, Pheiffer Carmen, Goedecke Julia H (2020) Exercise training results in depot-specific adaptations to adipose tissue mitochondrial function. Sci Rep 10:3785.
Brand 2020 J Clin Med	2020	Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667.
Schoepf 2020 Nat Commun	2020	Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5
Jacques 2020 FASEB J	2019	Jacques M, Kuang J, Bishop DJ, Yan X, Alvarez-Romero J, Munson F, Garnham A, Papadimitriou I, Voisin S, Eynon N (2019) Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study. FASEB J 34:2978-86.
Rose 2019 Am J Physiol Endocrinol Metab	2019	Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Børsheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. https://doi.org/10.1152/ajpendo.00084.2019
Tyrrell 2019 Circ Res	2019	Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298–314.
Braganza 2019 JCI Insight	2019	Braganza A, Corey CG, Santanasto AJ, Distefano G, Coen PM, Glynn NW, Nouraie SM, Goodpaster BH, Newman AB, Shiva S (2019) Platelet bioenergetics correlate with muscle energetics and are altered in older adults. JCI Insight 5:128248.
Lu 2018 Cell Rep	2018	Lu Z, Cui Y, Wei X, Gao P, Zhang H, Wei X, Li Q, Sun F, Yan Z, Zheng H, Yang G, Liu D, Zhu Z (2018) Deficiency of PKD2L1 (TRPP3) exacerbates pathological cardiac hypertrophy by augmenting NCX1-mediated mitochondrial calcium overload. Cell Rep 24:1639-52.
Cardinale 2018 Front Physiol	2018	Cardinale DA, Larsen FJ, Schiffer TA, Morales-Alamo D, Ekblom B, Calbet JAL, Holmberg HC, Boushel R (2018) Superior intrinsic mitochondrial respiration in women than in men. Front Physiol 9:1133.
Nacarelli 2018 Geroscience	2018	Nacarelli T, Azar A, Altinok O, Orynbayeva Z, Sell C (2018) Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts. Geroscience 40:243-56.
Birkenmeier 2016 Int J Cancer	2016	Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann Martin‐Leo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46.
Warne 2015 J Biol Chem	2015	Warne J, Pryce G, Hill JM, Shi X, Lennerås F, Puentes F, Kip M, Hilditch L, Walker P, Simone MI, Chan AWE, Towers GJ, Coker AR, Duchen MR, Szabadkai G, Baker D, Selwood DL (2015) Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis. J Biol Chem 291:4356-73.
Scandurra 2010 Adv Exp Med Biol	2010	Scandurra FM, Gnaiger E (2010) Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. https://doi.org/10.1007/978-1-4419-1241-1_2

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-{{Publication
+<!--        BANNER ACROSS TOP OF PAGE        -->
-|title=Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E (2006) Preserved coupling of oxidative phosphorylation but decreased mitochondrial respiratory capacity in IL-1ß treated human peritoneal mesothelial cells. Cell Biochem Biophys 44:179-86.
+{{Template:OROBOROS_header_page_name}}
-|info=[http://www.ncbi.nlm.nih.gov/pubmed/16456220 PMID: 16456220], [[File:PDF.jpg|100px|link=http://www.bioblast.at/images/c/cb/Stadlmann_2006_Cell_Biochem_Biophys.pdf |Bioblast pdf]]
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-|authors=Stadlmann S, Renner K, Pollheimer J, Moser PL, Zeimet AG, Offner FA, Gnaiger E
+</div>
-|year=2006
-|journal=Cell Biochem Biophys
+<!--        TODAY'S FEATURED CONTENT        -->
-|abstract=The peritoneal mesothelium acts as a regulator of serosal responses to injury, infection, and neoplastic diseases. After inflammation of the serosal surfaces, proinflammatory cytokines induce an “activated” mesothelial cell phenotype, the mitochondrial aspect of which has not previously been studied. After incubation of cultured human peritoneal mesothelial cells with interleukin (IL)-1β for 48 h, respiratory activity of suspended cells was analyzed by high-resolution respirometry. Citrate synthase (CS) and lactate dehydrogenase (LDH) activities were determined by spectrophotometry. Treatment with IL-1β resulted in a significant decline of respiratory capacity (''p'' < 0.05). Respiratory control ratios (i.e., uncoupled respiration at optimum carbonyl cyanide p-trifluoromethoxyphenylhydrazone concentration divided by oligomycin inhibited respiration measured in unpermeabilized cells) remained as high as 11, indicating well-coupled mitochondria and functional integrity of the inner mitochondrial membrane. Whereas respiratory capacities of the cells declined in proportion with decreased CS activity (''p'' < 0.05), LDH activity increased (''p'' < 0.05). Taken together, these results indicate that IL-1β exposure of peritoneal mesothelial cells does not lead to irreversible defects or inhibition of specific components of the respiratory chain, but is associated with a decrease of mitochondrial content of the cells that is correlated with an increase in LDH (and thus glycolytic) capacity.
+{| role="presentation" id="mp-upper" style="width: 100%; margin-top:4px; border-spacing: 0px;"
-|keywords=Peritoneal mesothelial cells, Interleukin-1β, Mitochondria, Respiration, Citrate synthase, Lactate dehydrogenase, Cell viability
+<!--        1ST BOX | BIOBLAST ALERT 2020 - LEFT COLUMN        -->
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+<div id="mp-itn" style="padding:1em 1em;">[[File:O2k-Publications.jpg|center|350px|Oroboros Ecosystem Agenda 2020]]</div>
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+<div id="mp-itn" style="padding:0.1em 0.6em;">{{Oroboros Ecosystem Agenda list}}</div>
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+== O2k-Publications alert ==
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