MitoEAGLE MC Meeting 2021

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MitoEAGLE MC Meeting 2021

Publications in the MiPMap
COST Action MitoEAGLE

MitoEAGLE MC Meetingvia email: The duration of the COST Action MitoEAGLE has been extended to 2021 Feb 28. We requested a further extension, so far without success.

This MC Meeting is initiated by a circular to MC Members and Substitutes, asking for written summaries to be presented on this website and included in the MitoEAGLE report. The MC Meeting will extend until 2021-Feb-23 as the final date for collection of input from our Working Groups and MC.

» MitoEAGLE

MitoEAGLE (2021-02-10 to 23) MitoGlobal

Abstract:


TASK

Dear MC Member and MC Substitues. Please provide information on the following topics (questions) that applied to your activities per mail to [email protected] until February 23rd


Objectives

1. Dissemination of updated knowledge and know-how among the partners (Achievement of a specific tangible output that cannot be achieved without international coordination)
The dissemination of updated knowledge is important for experienced researchers, especially regarding current projects. As all MitoEAGLE publications are open access, any interested researcher has immediate access to the results of the action and can benefit from it. The MitoEAGLE website is another useful tool to support the dissemination of knowledge, as it offers a large collection of relevant preprints, publications, and protocols, which are always up-to-date and therefore create a platform where recent know-how is accessible. Additionally, MitoEAGLE action papers are also published on the Facebook and the Research Gate page.
Moreover, several projects are still in the process of final manuscript preparation, such as harmonization of protocols, which not only help to create clear guidelines for other researchers but also lead to the exchange of know-how among the individual Working Groups. Currently, with the COVID-19 crisis several international studies are running slow, and therefore a big delay in unifying procedures and creating reference values and determining the best experimental approaches to mitochondrial respirometry in general occurs.
2. Collaborative relationships among the participating groups of the Action and interested end-users
Up to now, the outstanding example of collaborative work during the COST MitoEAGLE Action, which builds and improves the relationship among MitoEAGLE member and interested end-user, is the MitoEAGLE paper "Mitochondrial physiology". 666 scientists from all over the world joint for this manuscript and the outcome can be tracked on the MitoEAGLE website and is therefore accessible for researchers and the public. It was submitted in the Bioenergetics Communication Journal: https://www.mitoeagle.org/index.php/BEC_2020.1_doi10.26124bec2020-0001.v1
3. Harmonized protocols across research groups
Working Group meetings were organized in order to proceed intensively with the harmonization of protocols across research groups and to compare protocols (sample preparation, experimental details)
4. Coordinated research activities of scientific proposals in the European Research Area (Achievement of a specific tangible output that cannot be achieved without international coordination)
The progress in the protocol harmonization is a perfect example for successful coordinated research activity in the European research area. All WGs participated and are preparing manuscripts in their respective field of interest. Thereby the knowledge of various laboratories and research groups all over Europe (and overseas) are combined. The MitoEAGLE terminology BEC publication is worth mentioning under this objective. Especially in the field of mitochondrial terminology,where so much conflict regarding expressions and nomenclature existed and still partly persists, it is important to clarify the topic with a structured publication. This manuscript will facilitate particularly interdisciplinary cooperation across borders, as it helps to establish not only a common language but also clarifies concepts.
5. Increased number of active participants in the course of the COST Action
In order to maintain the success achieved in this objective, the MitoEAGLE Action welcomes the policy of supporting and establishing Europe-wide centers of excellence in science. Furthermore, the action emphasizes the clearance of obstacles by creating cooperation opportunities for all participants, especially for ITCs, ECIs, and female researchers.
6. Unique well-coordinated network of senior researchers and young investigators
With our meet the expert groups we are coordinating a balanced network between young and senior scientists. This way we motivate senior researchers to mentor the younger investigators and also attract the young scientist to join meetings and ask questions they always wanted to ask. The idea of MitoEAGLE mentors is not only for MitoEAGLE events but also as an opportunity for students and ECIs to get in contact with a mentor at any time.
7. Well established stakeholders included
Many established researchers and professors, who are highly renowned in mitochondrial research, joined the MitoEAGLE action. These members help to achieve the goals of the COST action through active participation in research projects, mentorship or public lectures. In general, they support the action with their knowledge and promote the agenda of MitoEAGLE even further. In addition, we are able to welcome numerous universities and other institutions as members of our COST Action.Particularly noteworthy are the 56 institutions that act as STSM hosts.
8. Spirit of mentorship and collaboration in contrast to fierce competition which characterised early decades of bioenergetics
Working on joint publications or data collections and writing joint guidelines ensures effective collaboration and not competition. Our current studies are an excellent example, as we inform all members via email newsletters about the current status of a manuscript or inform them about open calls in the Working Groups in order for them to contribute if interested. Therefore, if someone is interested in current studies, they can contact the WG-leaders or other listed members any time
9. Applications for funding to support international collaborative research projects
10. Results of collaborative research projects within the COST Action, particularly related to STSMs supported by the Action.
The MitoEAGLE BEC2020.1 is the result of a large-scale collaboration of 666 co-authors within the MitoEAGLE project.
11. MITOEAGLE recommendations: The goal is to increase the value and reduce the noise in mitochondrial research. Prespecified and time-stamped protocols are needed in practice, and researchers need to be introduced into adhering to publicly deposited protocols in practice. MITOEAGLE recommendations will provide practical guidelines for students, scientists and stakeholders.
The harmonization of protocols across research groups and the comparison of protocols is the beginning of the task to provide a guideline for all researchers and support them with future writing tasks. Moreover, the MitoEAGLE publication brings a better understanding of the terminology in mitochondrial research.
12. A monitored database – centres of excellence: The MITOEAGLE database will provide an invaluable tool for mitochondrial studies in the transition from exploratory preclinical research to clinical and pharmacological applications. Centres of excellence will emanate from the project’s working groups providing training programmes and diagnostic services
A training programme has been developed for instructors in proficiency training,allowing for the establishment of Centers of excellence based on inter-laboratory quality checks, to reduce the variability of data obtained and generate a database with solid reference values on mitochondrial respiratory function in different tissues and species.
13. Training: Enhance the rigorous training activities particularly for PhD students and young researchers (STSMs, Schools, Workshops, Conferences) in order to establish the practical guidelines introduced by MITOEAGLE and to enhance research results in the long term
Once a year a training school is organized where the participation of students and ECIs are financially supported and mitochondrial research is taught.


Deliverables

1. Guidelines for future research and recommendations for the evaluation of respiratory characteristics in human respirometric samples (WG1)
2. A database on mt fitness evaluated with humans’ cells and tissues (WG1)
3. Training of researchers towards improved reproducibility of sample preparation and respirometric evaluation (1/3 - WG1)
MiPschool_Obergurgl_2017
4. Training of researchers towards improved reproducibility of sample preparation and respirometric evaluation (2/3 - WG1)
MiPschool_Tromso-Bergen_2018
5. Training of researchers towards improved reproducibility of sample preparation and respirometric evaluation (3/3 - WG1)
MiPschool_Coimbra_2019
6. Qualitative and quantitative evaluation of results obtained in ongoing studies by comparison with a reference sample (WG1)
7. An expanded MitoEAGLE database (WG1)
8. A joint publication documenting the results of the MitoEAGLE-PT (WG1)
9. A multi-authored publication towards a unification of concepts and nomenclature in mitochondrial physiology (1/3 - WG1)
BEC 2020.1
10. A multi-authored publication towards a unification of concepts and nomenclature in mitochondrial physiology (2/3 - WG1)
BEC 2020.1
11. A multi-authored publication towards a unification of concepts and nomenclature in mitochondrial physiology (3/3 - WG1)
BEC 2020.1
12. A library of protocols for sample preparation and examination by respirometry (WG1)
13. A multi-authored publication with recommendations of comparable standard protocols and procedures (WG1)
BEC 2020.1
14. Guidelines as to the optimum use of a reference sample for determination of respiration and related parameters of interest (WG1)
15. The MitoEAGLE data management system (WG1)
16. A continuously updated MitoEAGLE database for the use as reference data and guideline towards application of optimised protocols, ultimately leading towards standardisation (WG1)
17. A joint publication on the use of the MitoEAGLE database and management system (WG1)
BEC 2020.1
18. An education programme for the use of MitoEAGLE database and management system (WG1)
19. A MitoEAGLE database on muscle tissue from humans and model organisms (WG2)
20. A set of guidelines for future studies on mitochondrial bioenergetics in muscle tissue (WG2)
21. A draft of the review manuscript (WG2)
MitoEAGLE muscle 1
22. Guidelines for future research and recommendations for the evaluation of respiratory characteristics in fat tissue (WG3)
23. A database on mt-fitness evaluated with fat tissue from humans and model organisms and post-study reports (PubMed Commons) (WG3)
24. A draft of the review manuscript (WG3)
25. SOPs for blood cell separation and respirometric characterization open for the research community (WG4)
MitoEAGLE blood cells 1
26. MitoEAGLE data repository for comparative data evaluation, planning of future studies data mining (WG4)
27. Publication with a set of reference data (WG4)

Feedback to other outputs

  • Action Outputs / Achievements as direct results from the COST Action activities. These can be codified knowledge, tacit knowledge, technology and societal applications
  • The impact of the Action on the careers, skills and network of researchers, stakeholder engagement, and the list of specific impacts resulting from the action
  • The Action's Dissemination and Exploitation Activities
  • Please describe the Action’s dissemination and exploitation approach as well as all activities undertaken to ensure dissemination and exploitation of Action results and the effectiveness of these activities
  • Taking into account the achievements, impacts and policy implementation of the Action - please describe the two most significant Successes of the Action



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