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• Basal metabolic rate
  31 bytes (3 words) - 06:11, 25 October 2011
• Resting metabolic rate
  ...te]]) is the position of the subject during measurement. Resting metabolic rate is the largest component of the daily energy budget in most human societies == Resting and sleeping metabolic rate, RMR and SMR ==
  1 KB (209 words) - 13:13, 19 November 2016

Page text matches

• Melzer 2011 Eur J Obstet Gynecol Reprod Biol
  |title=Melzer K, Schutz Y, Kayser B (2011) Normalization of basal metabolic rate for differences in body weight in pregnant women. Eur J Obstet Gynecol Repr |keywords=Basal metabolic rate, Body weight
  427 bytes (61 words) - 16:17, 30 June 2012
• Resting metabolic rate
  ...te]]) is the position of the subject during measurement. Resting metabolic rate is the largest component of the daily energy budget in most human societies == Resting and sleeping metabolic rate, RMR and SMR ==
  1 KB (209 words) - 13:13, 19 November 2016
• Elasticity
  ...the specific concentration of the metabolite (s) that will give a specific rate (r) of the enzyme activity" (See Figure).
  1 KB (151 words) - 11:53, 25 November 2020
• Savage 2007 Proc Natl Acad Sci U S A
  ...man AB, Woodruff WH, West GB (2007) Scaling of number, size, and metabolic rate of cells with body size in mammals. Proc Natl Acad Sci U S A 104:4718-23. ...trategy in which cell volume is body size dependent and cellular metabolic rate is roughly invariant with body size. Data for slowly dividing neurons and a
  2 KB (346 words) - 03:18, 24 August 2021
• Weibel 2004 Respir Physiol Neurobiol
  ...e LD, Schmitt B, Hoppeler H (2004) Allometric scaling of maximal metabolic rate in mammals: muscle aerobic capacity as determinant factor. Respir Physiol N ...y features and mechanisms different from those determining basal metabolic rate.
  2 KB (293 words) - 10:07, 11 December 2019
• Background state
  ...to stimulate flux to the level of the reference state. Alternatively, the metabolic control variable ''X'' is an inhibitor, which is present in the background
  1 KB (177 words) - 18:19, 10 November 2020
• Zhang 2002 Int J Obes Relat Metab Disord
  ...er P, Kovera AJ, Albu J, Pi-Sunyer FX, Boozer CN (2002) Sleeping metabolic rate in relation to body mass index and body composition. Int J Obes Relat Metab ...(BMI, kg/m(2)), and fat-free mass (FFM); and to compare resting metabolic rate (RMR) with SMR during different periods of sleep.
  2 KB (358 words) - 09:01, 9 August 2016
• Quemeneur 2022 Sci Rep
  ...t S, Zambonino-Infante JL, Salin K (2022) The relationships between growth rate and mitochondrial metabolism varies over time. https://doi.org/10.1038/s415 ...l traits. Our results emphasize the need to evaluate whether mitochondrial metabolic traits of individuals can change over time.
  2 KB (302 words) - 12:38, 22 November 2022
• Wone 2013 Comp Biochem Physiol A Mol Integr Physiol
  ...with membrane fatty acids in mice selected for increased maximal metabolic rate. Comp Biochem Physiol A Mol Integr Physiol 165:70-8. ...s known about the FA profiles that underpin variation in maximal metabolic rate (MMR). We examined membrane FA composition of liver and skeletal muscle in
  2 KB (280 words) - 11:32, 8 November 2016
• Tranah 2011 Mitochondrion
  ..., Cummings SR, Liu Y (2011) Mitochondrial DNA variation in human metabolic rate and energy expenditure. Mitochondrion 11:855-61. ...itochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.
  1 KB (178 words) - 09:48, 3 August 2015
• Porter 2014 Am J Physiol
  ...eletal muscle mitochondrial dysfunction contributes to increased metabolic rate in burn victims.
  2 KB (339 words) - 13:01, 30 November 2018
• Sjoedin 1996 Med Sci Sports Exerc
  ...= [[resting metabolic rate]]) or basal conditions (BMR = [[basal metabolic rate]]). This article presents data on BMR from elite endurance athletes (4 fema |keywords=Basal metabolic rate, Resting metabolic rate, Physical exercise
  2 KB (263 words) - 13:12, 30 June 2012
• Melzer 2010 Ann Nutr Metab
  ...vain M, Kayser B (2010) Prepregnancy body mass index and resting metabolic rate during pregnancy. Ann Nutr Metab 57:221-7. |abstract=AIM: The resting metabolic rate (RMR) varies among pregnant women. The factors responsible for this variabi
  2 KB (292 words) - 16:44, 17 March 2015
• Grimpo 2014 Comp Biochem Physiol A Mol Integr Physiol
  ...K, Kutschke M, Kastl A, Meyer CW, Heldmaier G, Exner C, Jastroch M (2014) Metabolic depression during warm torpor in the Golden spiny mouse (''Acomys russatus' ...mperature and metabolic rate. In Golden spiny mice, reduction of metabolic rate at mild temperatures is not triggered by depression of substrate oxidation
  2 KB (327 words) - 11:08, 27 March 2018
• Heimler 2022 MitoFit
  ...na AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. https://doi.org/10.26124/mitofit:2022 ..._2022_MitoFit.pdf Platelet bioenergetics associated with resting metabolic rate and exercise capacity in older women]<br/>
  3 KB (343 words) - 22:09, 16 February 2023
• Arciero 1993 J Appl Physiol
  |title=Arciero PJ, Goran MI, Poehlman ET (1993) Resting metabolic rate is lower in women than in men. J Appl Physiol 75: 2514-2520. |abstract=This study examined gender differences in resting metabolic rate (RMR) across a broad age spectrum after controlling for differences in body
  1 KB (212 words) - 14:43, 30 June 2012
• Weibel 2005 J Exp Biol
  |title=Weibel ER, Hoppeler H (2005) Exercise-induced maximal metabolic rate scales with muscle aerobic capacity. J Exp Biol 208:1635-44. ...l design is the result rather than the cause of the evolution of metabolic rate scaling. The remaining question is why the energy needs of locomotion scale
  2 KB (383 words) - 22:59, 16 January 2021
• Weber 1987 Am J Physiol
  ...Lactate kinetics in exercising Thoroughbred horses: regulation of turnover rate in plasma. Am J Physiol 253: R896-R903. ...coarse and fine controls for the regulation of plasma metabolite turnover rate.
  2 KB (277 words) - 15:22, 28 October 2013
• Unterluggauer 2008 Biotechnol J
  ...d mitochondrial function, two major pathways implicated in controlling the rate of aging.
  2 KB (234 words) - 14:24, 27 March 2015
• Liu 1990 Mar Biol
  ...xic salinity transfers did not generally correlate with the time course of metabolic heat flux.
  2 KB (306 words) - 05:35, 23 November 2021
• Normalization of rate
  ...iency |flux control efficiencies]] are based on internal normalization for rate in a reference state, are independent of externally measured markers and, t {{#ask:[[Additional label::Normalization of rate]]
  2 KB (260 words) - 23:06, 10 November 2020
• Hand 2000 Thermochim Acta
  ...ever, the adenylate energy status and time interval required for achieving metabolic depression are markedly different between the two conditions. |keywords=Twin-Flow, Metabolic depression, Dormancy, ''Artemia franciscana, Austrofundulus limnaeus, Euna
  3 KB (339 words) - 09:41, 9 November 2016
• Magierecka 2023 Abstract IOC160
  ...lowed by a measurement of maximum metabolic rate (MMR), standard metabolic rate (SMR) and mitochondrial function, predicting that measures of mitochondrial
  2 KB (346 words) - 12:23, 6 June 2023
• Rees 2022 J Exp Biol
  ...ll arches, or greater cardiac respiratory capacity had higher whole-animal metabolic rates. The overall model fit and the explanatory power of individual predic |keywords=Fundulus, Gill morphology, Heart, Metabolic rate, Mitochondria, Oxygen transport cascade
  2 KB (342 words) - 10:11, 10 August 2022
• Nelson 2016 J Fish Biol
  |title=Nelson JA (2016) Oxygen consumption rate v. rate of energy utilization of fishes: a comparison and brief history of the two ...urement in its own right that is not necessarily synonymous with metabolic rate. Because all extant fishes are obligate aerobes (many fishes engage in subs
  2 KB (350 words) - 23:10, 15 July 2022
• Stickle 1989 Biol Bull
  |title=Stickle WB, Kapper MA, Liu LL, Gnaiger E, Wang SY (1989) Metabolic adaptations of several species of crustaceans and molluscs to hypoxia: tole ...inity at 20 °C in ''Callinectes sapidus''. Greater depression of metabolic rate occurs in molluscs during anoxia exposure (and is correlated with greater h
  2 KB (316 words) - 05:26, 23 November 2021
• Lebenzon 2022 Proc Natl Acad Sci U S A
  ...E, Turnbull KF, Staples JF, Sinclair BJ (2022) Reversible mitophagy drives metabolic suppression in diapausing beetles. Proc Natl Acad Sci U S A 119:e2201089119 ...tochondrial degradation in insect tissues over the winter and whole-animal metabolic suppression.
  2 KB (345 words) - 14:38, 11 April 2024
• Salin 2016 Physiol Biochem Zool
  ...udolf AM, Anderson GJ, Selman C, Metcalfe NB (2016) Variation in metabolic rate among individuals is related to tissue-specific differences in mitochondria ...specific relationships between mitochondrial properties and whole-organism metabolic traits were observed. Specifically, SMR was positively associated with LEAK
  3 KB (353 words) - 16:53, 26 March 2018
• Metabolic control variable
  ...(background rate ''Y_X'') and a [[reference state]] Z (reference rate ''Z_X''). ''X'' may be a stimulator or activator of flux, inducin
  858 bytes (123 words) - 18:19, 10 November 2020
• Chabot 2016 J Fish Biol
  |title=Chabot D, McKenzie DJ, Craig JF (2016) Metabolic rate in fishes: definitions, methods and significance for conservation physiolog
  479 bytes (61 words) - 07:58, 28 June 2022
• Staples 2010 Abstract IOC60
  ...Chung DJ, Armstrong C (2010) Fast in, slow out: Kinetics of mitochondrial metabolic suppression during hibernation entrance and arousal. MiPNet15.10. ...n only in torpor and early arousal. The “fast” initiation of mitochondrial metabolic suppression during entrance and its “slow” reversal during arousal sugg
  2 KB (261 words) - 16:52, 27 March 2018
• Flux control efficiency
  ...='''Flux control efficiencies''' express the control of respiration by a [[metabolic control variable]], ''X'', as a fractional change of flux from ''Y_{X</s ...[[flux control ratio]]s and analogous to [[elasticity|elasticities]] of [[metabolic control analysis]], the flux control efficiency of ''X'' upon background ''
  8 KB (1,272 words) - 18:27, 1 January 2021
• Molnar 1997 Eur J Pediatr
  ...(1997) The effect of obesity, age, puberty and gender on resting metabolic rate in children and adolescents. Eur J Pediatr 156: 376-381. ...ing the important effect of age on RMR. CONCLUSIONS: The resting metabolic rate of obese and control children is not different when adjusted for body compo
  2 KB (371 words) - 14:55, 30 June 2012
• Krumschnabel 2000a J Exp Biol
  ...unaltered during acute hypoxia but was increased during prolonged hypoxia, metabolic depression amounting to 7% during acute hypoxia and 30% during prolonged hy |keywords=hypoxia, metabolic depression, protein synthesis, Na+/K+-ATPase, goldfish, Carassius auratus,
  2 KB (296 words) - 12:05, 23 January 2019
• Haugen 2003 Am J Clin Nutr
  ...n ZV, Kearney JT, Hill JO (2003) Variability of measured resting metabolic rate. Am J Clin Nutr 78: 1141-1145. The necessity of a 12-h fast before resting metabolic rate (RMR) is measured is often a barrier to measuring RMR.
  2 KB (279 words) - 13:37, 30 June 2012
• Schiffer 2016 Am J Physiol Cell Physiol
  ...tion may explain the pronounced individual variations in resting metabolic rate (RMR). RMR was determined in healthy humans by indirect calorimetry and cor |keywords=High-resolution respirometry, Mitochondria, Resting metabolic rate
  2 KB (343 words) - 13:42, 7 March 2020
• Power
  ...ower and heat flux of irreversible processes are distinguished as the time rate of Gibbs energy and enthalpy changes, respectively.
  509 bytes (71 words) - 10:05, 9 February 2024
• Guan 1999 Cytotechnol
  ...ction were related through the extent of reaction (advancement) to overall metabolic activity (flux). The fact that this approach can be used for medium optimis |keywords=Calorimetry, Capacitance, Heat flux, Medium optimisation, Metabolic activity, On-line biosensor
  2 KB (324 words) - 10:26, 9 November 2016
• Darveau 2013 Abstract MiP2013
  ...M (2013) Diversity and evolution of mitochondrial metabolism: Proline as a metabolic reward for pollinators. Mitochondr Physiol Network 18.08. ...oxidation of pyruvate. This work illustrates how proline can be used as a metabolic reward for pollinators, and the diversity and evolution of mitochondrial me
  3 KB (383 words) - 11:10, 28 April 2017
• Speakman 2003 Proc Nutr Soc
  |title=Speakman JR, Selman C (2003) Physical activity and resting metabolic rate. Proc Nutr Soc 62: 621-634. ...eater than the direct energy cost of the exercise alone. Resting metabolic rate (RMR) is the largest component of the daily energy budget in most human soc
  2 KB (370 words) - 11:17, 27 March 2018
• Hunt 2018 PLoS Comput Biol
  ...tes), as opposed to net community growth rate (i.e. total community growth rate subtracting autotroph consumed by heterotroph), as predicted from the maxim
  3 KB (363 words) - 07:26, 6 November 2023
• Kemp 2000 Thermochim Acta (Vol 349)
  ...ated the formulation of a revised medium that improved the specific growth rate of CHO320 cells producing recombinant interferon-γ (IFN-γ), as well as al
  2 KB (258 words) - 13:40, 25 June 2014
• Clara 2016 Metabolism
  ...secretion from L-cells. It is, however, unclear whether the intracellular metabolic handling of OA is involved in this effect. ...te and extracellular acidification rate in response to OA and to different metabolic inhibitors with the Seahorse extracellular flux analyzer.
  2 KB (337 words) - 15:56, 24 March 2022
• Price 2016 J Thermal Biol
  ...cclimation in American alligators: Effects of temperature regime on growth rate, mitochondrial function, and membrane composition. J Thermal Biol p11. ...ized that alligators would acclimate to cold temperature by increasing the metabolic capacity of skeletal muscles and the heart. Additionally, we hypothesized t
  3 KB (410 words) - 15:44, 13 November 2017
• Podrabsky 1999 JEB
  sediments. The rate of oxygen consumption of diapause II in heart rate. Developmental arrest was identified by
  2 KB (350 words) - 17:54, 8 November 2016
• Heimler 2022 BEC
  ...na AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. Bioenerg Commun 2022.2. https:/ ...onships between platelet mitochondrial bioenergetics and resting metabolic rate (RMR), body composition, and exercise fitness in older adult women. We repo
  3 KB (396 words) - 16:42, 21 January 2024
• Gasmi 2021 Arch Toxicol
  ...ntributing factor to tumor progression, several studies highlight distinct metabolic characteristics in some tumors, including a relative decrease in avidity co
  2 KB (257 words) - 17:34, 5 October 2023
• Miettinen 2017 Trends Cell Biol
  ...cell-size-dependent metabolism becomes directly relevant for development, metabolic diseases, and aging.
  1 KB (172 words) - 03:29, 24 August 2021
• Gnaiger 1980 Thermal Analysis, Birkhaeuser
  ...b>i}''S''·d''t''^-1 is not equivalent to the anoxic rate of metabolic heat production. This approximation holds true for aerobic conditions only.
  2 KB (222 words) - 18:53, 22 November 2021
• Gnaiger 1980 Thermochim Acta
  ...e rate of heat production is considered an unspecific measure of metabolic rate applicable under aerobic and anoxic conditions. The interpretation of bioca ...t physiological conditions may lead to erroneous conclusions regarding the metabolic activity of organisms.
  3 KB (482 words) - 07:18, 9 February 2024
• Weber 1987b Am J Physiol
  ...The walk, trot, and canter represented 25, 45, and 55% VO2max. Mean heart rate went from 48.9 (rest) to 197 beats/min (gallop). Q ranged from 106 (rest) t
  2 KB (240 words) - 12:32, 26 February 2015
• Strobel 2012 Front Zool
  |title=Strobel A, Bennecke S, Leo E, Mintenbeck K, Pörtner HO, Mark FC (2012) Metabolic shifts in the Antarctic fish Notothenia rossii in response to rising temper ...MR was partially compensated during warm- acclimation (decreased below the rate observed after acute warming), while elevated PCO2 had no effect on cold or
  3 KB (459 words) - 09:15, 9 November 2016
• Rondot 2020 Thesis
  ...The metabolic properties of muscle tissue were further characterized using metabolic enzymes activity profile. These results further demonstrate the low potenti
  2 KB (294 words) - 16:54, 17 June 2020
• Boel 2020 J Exp Biol
  ...roved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558. ...muscle mitochondria than the other two species. ''Mus mattheyi'' presents metabolic innovations to ensure its homeostasis, by generating more ATP per oxygen co
  3 KB (352 words) - 18:01, 16 April 2020
• Tepp 2022 Biochem Biophys Rep
  ...k I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250. ...nificant decrease in the OxPhos capacity is substrate dependent indicating metabolic inflexibility when multiple substrates are available.
  2 KB (326 words) - 16:33, 22 March 2022
• Armstrong 2010 J Comp Physiol B
  ...eversibly inhibits SDH in torpor, but cannot fully account for the drastic metabolic suppression observed during this hibernation phase.
  2 KB (310 words) - 14:11, 15 June 2015
• Leibold 2022 PLoS One
  ...mse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https ...s been linked to an increased likelihood to develop and an exacerbation of metabolic syndrome, however fish that were calorically restricted from five days afte
  2 KB (268 words) - 15:12, 28 November 2022
• Clanton 2013 Compr Physiol
  ...Gladden LB (2013) Regulation of cellular gas exchange, oxygen sensing, and metabolic control. https://doi.org/10.1002/cphy.c120030 ...the issues discussed relate to the O₂ sensitivity of metabolic rate, O₂ kinetics in exercise, and influences of available O_{2</s
  2 KB (342 words) - 06:57, 28 June 2022
• Pamenter 2017 J Exp Biol
  ...xia. Changes in NMR mitochondrial metabolic plasticity mirror whole animal metabolic responses to hypoxia.
  2 KB (340 words) - 13:20, 28 March 2018
• Khan 2014 J Comp Physiol
  ...scope (AMS) was maximal at 24 °C, giving the impression that whole animal (metabolic) performance was optimised at a surprisingly high temperature. Mitochondria
  3 KB (480 words) - 14:54, 13 November 2017
• Kovalev 2018 EMBS
  ...lities in some specimens compared to the others result from more efficient metabolic regulation which in turn is related to higher mitochondrial capacities. |keywords=Metabolic allometry, High-resolution respirometry, Mussels, Mitochondrial Respiration
  3 KB (464 words) - 14:24, 26 February 2019
• Golub 2012 Am J Physiol Heart Circ Physiol
  ...ent of oxygen supply and is discordant with the conventional hypothesis of metabolic regulation of the oxygen supply to tissue. |keywords=Skeletal muscle, Respiratory rate, Interstitial PO2, Oxygen disappearance curve, Phosphorescence quenching me
  2 KB (341 words) - 17:11, 3 March 2015
• Bosy-Westphal 2004 Int J Obes Relat Metab Disord
  ...in REE, explained by body composition. Since a decrease in organ metabolic rate with increasing organ mass has been deduced from interspecies comparison in ...a view that, for practical purposes within humans, the specific metabolic rate is constant with increasing organ mass. Nonlinearity of REE on FFM was part
  3 KB (410 words) - 15:02, 30 June 2012
• P50
  ...''p''₅₀. The ''p''₅₀ depends on metabolic state and rate. (b) ''p''₅₀ is the oxygen partial pressure at which oxygen bin
  727 bytes (99 words) - 20:18, 19 November 2016
• Sirsat 2016 J Comp Physiol B
  ...ty increased steadily upon hatching as evidenced by the shift of metabolic rate from an ectothermic to endothermic phenotype and the increase of mitochondr
  3 KB (345 words) - 09:57, 9 November 2016
• Larsen 2011 FASEB J
  ...Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J 25:2843-52. doi:10.1096/fj.11-182139 ...sal respiration|basal metabolic rate]] (BMR) is referred to as the minimal rate of metabolism required to support basic body functions. It is well known th
  2 KB (316 words) - 10:42, 31 March 2022
• Chen 2023 Nat Commun
  ...ific overexpression of Cdo1 (Cdo1^LTG) increases basal metabolic rate of the mice and synergizes with exercise to ameliorate NAFLD. Mechanistical
  2 KB (269 words) - 17:42, 3 January 2024
• Schiffer 2013 Abstract MiP2013
  ...erg JO, Larsen FJ (2013) Dietary inorganic nitrate reduces basal metabolic rate in man. Mitochondr Physiol Network 18.08. |abstract=According to the rate-of-living and oxidative damage theory of aging, extended lifespan is predic
  3 KB (400 words) - 16:20, 27 March 2018
• Braz-Mota 2018 Sci Total Environ
  ...ase in reactive oxygen species (ROS) levels. Our findings reveal different metabolic responses between these two species in response to nCuO and Cu, which are p |keywords=CuO nanoparticles, Metabolic rate, Mitochondria respiration, Ornamental Amazon fishes, Oxidative stress, Reac
  3 KB (367 words) - 00:12, 12 January 2022
• Lemmer 2001 Med Sci Sports Exerc
  ...Fleg JL, Hurley BF (2001) Effect of strength training on resting metabolic rate and physical activity: age and gender comparisons. Med Sci Sports Exerc 33: ...pare age and gender effects of strength training (ST) on resting metabolic rate (RMR), energy expenditure of physical activity (EEPA), and body composition
  2 KB (369 words) - 14:36, 30 June 2012
• Lytovchenko 2015 Abstract MiP2015
  |abstract=Carcinogenesis is accompanied by significant remodeling of cellular metabolic pathways, in particular those involving mitochondria. These alterations lea ...s of cancer cells. As transport processes are often rate-limiting steps of metabolic pathways, mitochondrial carriers overexpressed in cancer might represent a
  2 KB (233 words) - 14:19, 9 November 2016
• DeLany 2013 TOS
  ...rican compared to Caucasian women and is associated with resting metabolic rate and cardiorespiratory fitness. ...women (CW). Lower energy expenditure, particularly lower resting metabolic rate (RMR) is observed in AAW. This low RMR may play a role in the greater obesi
  3 KB (384 words) - 12:14, 28 March 2018
• Hawkins 1985 Mar Ecol Prog Ser
  ...ing and associated activities are shown to add as much as 38 % to standard metabolic demands.
  2 KB (229 words) - 20:21, 22 November 2021
• Bianchi 2004 J Biol Chem
  ...V appears randomly distributed. Moreover, we show that Complex II is fully rate-limiting for succinate oxidation, clearly indicating the absence of substra
  2 KB (352 words) - 22:11, 16 February 2021
• Heichler 2022 MitoFit
  ...nce and microscopic imaging enables multiparametric monitoring of cellular metabolic responses due to Acetaminophen in a single assay and provides an overall pi
  3 KB (353 words) - 08:36, 8 January 2023
• Wolf 2022 Abstract Bioblast
  ...nce and microscopic imaging enables multiparametric monitoring of cellular metabolic responses due to Acetaminophen in a single assay and provides an overall pi
  3 KB (324 words) - 08:37, 28 July 2022
• Heichler 2022 BEC
  ...ce, and microscopic imaging enables multiparametric monitoring of cellular metabolic responses due to acetaminophen in a single assay and provides an overall pi
  3 KB (364 words) - 16:41, 21 January 2024
• Molina 2022 Abstract Bioblast
  ...JA</u> (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. '''Bioblast 2022: BEC Inaugural Confe ...onships between platelet mitochondrial bioenergetics and resting metabolic rate (RMR), body composition, and exercise fitness in women over 60 years of age
  3 KB (388 words) - 08:31, 28 July 2022
• Gnaiger 1989 Thermochim Acta
  |title=Gnaiger E (1989) Physiological calorimetry: heat flux, metabolic flux, entropy and power. Thermochim Acta 151:23-34. https://doi.org/10.1016 ...ower and heat flux of irreversible processes are distinguished as the time rate of Gibbs energy and enthalpy changes, respectively. Power is the product of
  2 KB (365 words) - 07:41, 9 February 2024
• McLennan 2023 Abstract IOC160
  ...be among-individual variation in metabolic rate, since a higher metabolic rate could allow a greater allocation of energy to dominance-related traits, suc
  2 KB (305 words) - 12:16, 6 June 2023
• Kaufmann 1990 JEB
  |abstract=The relationship between swimming speed and respiration rate for larvae and juveniles (1.5-600 mg fresh mass) of two cyprinid species, ' 3. Standard and routine metabolic rates scaled with an allometry of M^-0.23, active rates with M<su
  2 KB (315 words) - 09:01, 9 November 2016
• Larsen 2014 Am J Clin Nutr
  ...Lundberg JO, Weitzberg E (2014) Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans. Am J Clin Nutr 99:843-50. ...ria. Such an effect might be reflected in changes in the resting metabolic rate (RMR) and formation of reactive oxygen species. The bioactivation of nitrat
  2 KB (334 words) - 16:21, 27 March 2018
• Tang 2022 Elife
  ...sed cholinergic signaling through the modulation of glycolysis has several metabolic benefits particularly to increase energy expenditure and heat production up
  2 KB (265 words) - 14:21, 17 August 2023
• Cortassa 2019 Front Physiol
  ...s indicate that the control of catabolism is highly distributed across the metabolic network suggesting that fuel selection between FAs and Glc goes well beyond
  3 KB (448 words) - 05:42, 26 October 2023
• Specific quantity
  ...n consumption and body mass by the fact that mass-specific basal metabolic rate (oxygen flux) does not increase proportionally and linearly with body mass. File:Rate.png |'''Normalization of rate.''' '''(A)''' Cell respiration is normalized for (1) the experimental '''Sa
  2 KB (237 words) - 12:16, 16 October 2022
• Byrne 1990 Biol Bull
  |title=Byrne RA, Gnaiger E, McMahon RF, Diez TH (1990) Behavioral and metabolic responses to emersion and subsequent reimmersion in the freshwater bivalve, ...r_Bivalve_Corbicula_fluminea/links/0c960533aa17cd6e69000000/Behavioral-and-Metabolic-Responses-to-Emersion-and-Subsequent-Reimmersion-in-the-Freshwater-Bivalve-
  2 KB (293 words) - 05:48, 23 November 2021
• Schiffer 2018 Am J Physiol Renal Physiol
  ...thick ascending limb of Henle are considered to have the highest metabolic rate, which is related to the high mitochondria content needed to sustain suffic
  2 KB (339 words) - 10:52, 17 September 2018
• Wu 2007 Am J Physiol Cell Physiol
  ..., Lemire K, Orrell J, Teich J, Chomicz S, Ferrick DA (2007) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic ...ate of glycolysis and a linked attenuation in their OXPHOS capacity. These metabolic alterations provide a mechanistic explanation for the growth advantage and
  3 KB (384 words) - 15:49, 4 June 2022
• Van Beek MiP2010
  |abstract=Proliferating cancer cells often show a high glycolytic rate with most of the glucose converted to lactate despite adequate oxygen avail
  4 KB (628 words) - 16:09, 15 February 2016
• Jensen 2021 Free Radic Biol Med
  ...ochondria isolated during summer and hibernation arousals, where metabolic rate is normal. Consistent with these ''in vitro'' effects, we find strong seaso
  2 KB (337 words) - 14:39, 21 July 2021
• Fangue 2009 J Exp Biol
  ...en subspecies at higher acclimation temperatures. Whole-organism metabolic rate was greater in fish of the northern subspecies at all acclimation temperatu
  3 KB (358 words) - 13:06, 12 October 2017
• Salin 2015 Proc Biol Sci
  ...y may have significant consequences for animal performance, such as growth rate and reproductive output. We explore the adaptive significance of such varia
  2 KB (300 words) - 12:13, 27 March 2018
• Krumschnabel 2000b J Exp Biol
  ...m goldfish by 51% and of hepatocytes from trout by 32%. During anoxia, the rate of protein synthesis decreased by approximately 50% in goldfish hepatocytes |keywords=lactate production, K+ flux, intracellular free Ca2+, metabolic depression, Carassius auratus, Oncorhynchus mykiss
  2 KB (329 words) - 12:05, 23 January 2019
• Gregori 2002 Methods Cell Sci
  ...DiOC6(3), enabling the determination by flow cytometry of the respiration rate of ''D. tertiolecta''.
  2 KB (293 words) - 09:47, 9 November 2016
• Braz-Mota 2017 Thesis
  ...irectly related to an increase in ROS levels. Our findings reveal that the metabolic responses of these two species in response to nCuO and Cu, which are probab
  2 KB (324 words) - 17:02, 9 November 2017
• Gilliat-Wimberly 2001 J Am Diet Assoc
  ...PD, Carroll SS (2001) Effects of habitual physical activity on the resting metabolic rates and body compositions of women aged 35 to 50 years. J Am Diet Assoc 1 To examine the effect habitual physical activity has on resting metabolic rate (RMR) and body composition (fat-free mass[FFM], fat mass, and percent body
  3 KB (390 words) - 10:46, 7 July 2015
• Ahluwalia 2017 Sci Rep
  ...nd it is generally accepted that were in-vitro cultures to obey allometric metabolic scaling, they would have more predictive potential and could, for instance,
  2 KB (221 words) - 05:49, 17 August 2017
• Bakke 2012 Biochim Biophys Acta
  ...ic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase. Biochim Biophys ...two most abundant fatty acids in our diet are partitioned toward different metabolic pathways in muscle cells, and this may be relevant to understand the link b
  2 KB (340 words) - 12:05, 22 March 2016
• Sirsat 2016 Biol Open
  ...t-hatching development of mitochondrial function, organ mass and metabolic rate in two ectotherms, the American alligator (''Alligator mississippiensis'') ...and a crocodilian, two ectotherms that never develop endothermy. Metabolic rate did not increase substantially in either species by 30 days post-hatching
  2 KB (336 words) - 16:06, 13 November 2017
• Saks 2000 Acta Physiol Scand
  ...lude that there exist multiple parallel regulatory factors controlling the rate of oxygen consumption in dependence of the workload. If creatine kinase is
  3 KB (406 words) - 12:41, 26 March 2015
• Brown 2013 J Exp Biol
  ...to changing substrate concentration might also contribute to mitochondrial metabolic regulation during torpor. The present study confirmed that succinate oxidat
  3 KB (333 words) - 12:06, 8 November 2016
• Mebarek 2011 Global Change
  ...representative of organic matter’s biological oxidation. The corresponding metabolic CO2 production was estimated to reach about 22 Pg C year−1 (1 Pg = 1015 g ...as the measure of O2 consumption by the Winkler chemical method or the CO2 metabolic production by coulometry. There is also an enzymatic method (Electron Trans
  3 KB (456 words) - 09:52, 9 November 2016
• Gnaiger 1983 J Exp Zool
  ...d environmental anoxia are presented and assessed in terms of ATP turnover rate. Present evidence suggests that unknown sources of energy in freshwater and ...onate production. While enzyme kinetics provides one key for understanding metabolic regulation, our insight remains incomplete without a complementary thermody
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• Sitnick 2013 Diabetes
  ...aw EE (2013) Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. Diabetes 62:3350-6. ...r altered IMTG accumulation and lipolysis in muscle insulin resistance and metabolic complications obesity.
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• Gnaiger 1998 BTK-COX
  ...climation and pathological defects. Biochemical adaptations yield distinct metabolic strategies under selective pressure over evolutionary time [4]. Evolutionar
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• Chennamsetty 2016 Cell Rep
  ...eased ability to utilize fats for energy and a decrease in basal metabolic rate and exercise capacity without altered thermogenesis. Collectively, our resu |keywords=NAT2, Nat1, Adipose tissue, Basal metabolic rate, Fatty acids, Insulin resistance, Mitochondria, Mitochondrial dysfunction,
  2 KB (317 words) - 11:55, 9 November 2017
• Martinez-Palma 2018 Neurotherapeutics
  ...cord. Together with previous findings, these results further support glial metabolic modulation as a valid therapeutic strategy in ALS. |keywords=ALS, DCA, Mitochondria, Aberrant glial cells, Glial toxicity, Metabolic modulation
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• Orynbayeva 2015 Nanomedicine (Lond)
  |title=Orynbayeva Z, Sensenig R, Polyak B (2015) Metabolic and structural integrity of magnetic nanoparticle-loaded primary endothelia ...ed polymeric MNPs on primary rat endothelial cells’ structural intactness, metabolic integrity and proliferation potential.
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• Venter 2015 J Clin Cell Immunol
  ...sic nutrient conditions in tissue niches and handle variation in intrinsic metabolic demand that is determined by differentiation ...hallenge. The purpose of the present study was to gain more insight in how metabolic specialization and versatility in fate and immune effector function of macr
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• Steinlechner-Maran 1996 Am J Physiol Cell Physiol
  ...as caused by changes in metabolic state, which correlated with respiratory rate.
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• Sambeat 2019 Nat Commun
  ...lic damage, highlighting the relevance of NRK1 as a therapeutic target for metabolic disorders.
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• Remie 2020 Am J Clin Nutr
  ...ar NAD⁺ concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. ...supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers.
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• Hamraz 2019 FASEB J
  ...ATP production by Krebs cycle. The latter is likely to constitute another metabolic adaptation to compensate for deficient oxidative phosphorylation that, impo
  2 KB (245 words) - 13:43, 15 January 2020
• Meade 1994 J Exp Zool
  ...limited in its ability to utilize anaerobic pathways to maintain metabolic rate in anoxic Environments.
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• Dube 2014 Am J Physiol Endocrinol Metab
  ...14) Effects of acute lipid overload on skeletal muscle insulin resistance, metabolic flexibility, and mitochondrial performance. Am J Physiol Endocrinol Metab 3 ...that enhanced mitochondrial performance with exercise is related to better metabolic flexibility and insulin sensitivity in response to lipid overload.
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• Smith 2021 Am J Physiol Endocrinol Metab
  ...imposes mitochondrial reductive stress and elicits multiple counterbalance metabolic responses in an attempt to restore bioenergetic homeostasis. ...imposes reductive stress that is not beneficial but rather detrimental to metabolic regulation.
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• MacDonald 2018 IOC130
  ..., respectively. The mitochondrial bioenergetic status greatly affected the rate of H₂O₂ consumption in heart but not liver mitochondr
  3 KB (419 words) - 14:04, 23 May 2018
• Lanza 2010 Curr Opin Clin Nutr Metab Care
  |title=Lanza IR, Nair KS (2010) Mitochondrial metabolic function assessed ''in vivo'' and ''in vitro''. Curr Opin Clin Nutr Metab C ...regulation of mitochondrial content by measuring the ''in vivo'' synthesis rate of individual mitochondrial proteins.
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• Lerchner 2019 Anal Bioanal Chem
  ...tabolic processes contribute from 30 to 40% to the overall heat production rate. Similar basal and antimycin A heat rates with cells under anoxic condition
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• Keidar 2023 Front Physiol
  ...rovides evidence of Ca²⁺ “push” and “pull” activity to maintain metabolic homeostasis in atrial cells.
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• Brown 2011 Am J Physiol Regul Integr Comp Physiol
  |title=Brown JC, Chung DJ, Belgrave KR, Staples JF (2011) Mitochondrial metabolic suppression and reactive oxygen species production in liver and skeletal mu ...close to torpid T(b). In liver, this passive thermal effect on respiration rate reflected reduced activity of all components of oxidative phosphorylation (
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• Basal respiration
  ...nder these conditions, '[[respiration]]' is not equivalent to '[[metabolic rate]]'. Basal respiration in humans and skeletal muscle mitochondrial function === Metabolic energy flow, flux, and rate ===
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• Keppner 2017 MiP2017
  ...al function of peripheral blood mononuclear cells (PBMCs) in subjects with metabolic syndrome. ...ear cells (PBMCs) of patients with diabetes type II [2], and patients with metabolic syndrome presented also altered mitochondrial function [1].
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• Brown 2012 Am J Physiol Regul Integr Comp Physiol
  |title=Brown JC, Chung DJ, Belgrave KR, Staples JF (2012) Mitochondrial metabolic suppression and reactive oxygen species production in liver and skeletal mu ...close to torpid T(b). In liver, this passive thermal effect on respiration rate reflected reduced activity of all components of oxidative phosphorylation (
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• Halbrook 2022 Nat Cancer
  ...limited respiration indirectly supports maintenance of aspartate pools, a rate-limiting biosynthetic precursor. Conversely, depletion of extracellular asp
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• Jeneson 2011 Am J Physiol Regul Integr Comp Physiol
  ...xperiments were simulated using a computational model of the oxidative ATP metabolic network in FT muscle featuring ADP and Pi feedback control of mitochondrial |keywords=Skeletal muscle, Mitochondria, Metabolic control, Computational modeling
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• Padinharayil 2023 Cancers (Basel)
  ...with different metabolic profiles may add to carcinogenesis through inter-metabolic coupling. Cancer cells frequently possess alterations in the mitochondrial
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• Villani 1997 Proc Natl Acad Sci U S A
  ...antly greater COX capacity relative to the residual endogenous respiration rate, and, correspondingly, a higher COX inhibition threshold above which the ov
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• Rossignol 2003 Biochem J
  ...e analysis of the effects of various mutations in mitochondrial DNA on the rate of mitochondrial protein synthesis has revealed the existence of a 'transla |keywords=complementation, Metabolic Control Analysis, mitochondrial diseases, mitochondrial DNA, oxidative phos
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• Szczepanowska 2016 EMBO J
  ...is essential for the efficient maturation of the mitoribosome and a normal rate of mitochondrial translation.
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• Kayser 2023 MiP2023
  ...y. Several studies have shown benefits on body mass and cardiovascular and metabolic variables, but more research is needed before systematically integrating hy
  2 KB (345 words) - 11:43, 2 May 2023
• Nemec 2017 Abstract MITOEAGLE Barcelona
  ...trength exercise intervention study, we examined the whole body and muscle metabolic characteristics in 34 seniors with subjective or mild cognitive impairment. ...mabilized muscle fibers to determine OXPHOS capacity, fatty acid oxidation rate and the magnitude of uncoupled respiration.
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• Wu 2021 Am J Physiol Cell Physiol
  ..., Lemire K, Orrell J, Teich J, Chomicz S, Ferrick DA (2021) Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic ...ate of glycolysis and a linked attenuation in their OXPHOS capacity. These metabolic alterations provide a mechanistic explanation for the growth advantage and
  3 KB (457 words) - 12:54, 24 May 2021
• Keppner 2020 Thesis
  ...ratory capacity of peripheral blood mononuclear cells on resting metabolic rate. PhD Thesis 100. ...e about the daily energy expenditure and its components. Resting metabolic rate (RMR) is with 60 - 80% the biggest component of daily energy expenditure an
  4 KB (547 words) - 18:43, 9 June 2020
• Henriques 2013 Thesis Universidade de Coimbra - Portugal
  |title=Henriques TAF (2013) High-resolution respirometry for metabolic profiling of acute rat hippocampal slices. Thesis Universidade de Coimbra - ...ative to glucose. As predicted, •NO titration decreased oxygen consumption rate (OCR) in acute rat hippocampal slices. This effect of nitric oxide on mitoc
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• Reference state
  ...he background state and the reference state is a step brought about by a [[metabolic control variable]] ''X''. If ''X'' stimulates flux (ADP, fuel substrate), i
  1 KB (179 words) - 18:14, 10 November 2020
• Ghanim 2017 Abstract IOC122
  ...greatly increase the comfort of patients and ideally increase the survival rate. ...to cancer cells. In particular, the research will focus on the process of metabolic transformation including aerobic glycolysis, extracellular acidification an
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• Jedlicka 2021 Physiol Res
  ...s when analyzed by both methods. In addition, mitochondrial ATP production rate was also significantly lower in platelets isolated from older adults. Varia
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• Van der Windt 2012 Immunity
  ...nitine palmitoyl transferase (CPT1a), a metabolic enzyme that controls the rate-limiting step to mitochondrial fatty acid oxidation (FAO). These results sh
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• Frederick 2014 J Biol Chem
  reported to confer resistance to metabolic defects phosphoribosyltransferase, the rate-limiting
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• Nystroem 1996 EMBO J
  AarcA mutant is manifested as an elevated rate of respiration and total metabolic activity during starvation.
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• Shimakawa 2020 Int J Mol Sci
  ...ws a capacity comparable to the net photosynthetic O₂ evolution rate. Although the respiratory and photosynthetic electron transports share the ...nd can then reach about half of the photosynthetic O₂ evolution rate. The light-enhanced dark respiration (here we termed it as light-enhanced r
  5 KB (797 words) - 14:12, 17 August 2023
• Kunz 2000 J Biol Chem
  ...capacity and increased flux control coefficient of COX, indicating severe rate limitations of oxidative phosphorylation by this enzyme.
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• Taylor 2021 Int J Mol Sci
  ...land WL, Reynolds PR, Bikman BT (2021) High-mobility group box 1 disrupts metabolic function with cigarette smoke exposure in a ceramide-dependent manner. Int ...onclusion, HMGB1 may be a necessary intermediate in the ceramide-dependent metabolic consequences of cigarette smoke exposure.
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• Touat 2018 J Clin Invest
  ...ship in NSCLC models, and highlight the potential for targeting DNA repair/metabolic crosstalks for cancer therapy.
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• Pecinova 2017 MiP2017
  ...nova A]] Targeting tumor cell proliferation by inhibition of mitochondrial metabolic pathways. ...sents one of the key cellular pathways for regeneration of cytosolic NAD+. Rate limiting component of the shuttle is mitochondrial FAD-dependent glycerol-3
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• Briston 2017 Sci Rep
  ...ensitise mitochondria to mPTP opening. Thus, cellular metabolic fluxes and metabolic environment dictate mitochondrial functional response to Ca²⁺ ov
  2 KB (324 words) - 12:54, 10 March 2020
• Holsgrove 2019 Thesis
  ...ir inability to regulate internal temperatures. An alteration of metabolic rate will drive modulations in cardiac function in order to meet the changing ox ...ng following temperature changes. We show that cold acclimation sensitised metabolic enzymes to acute changes in temperature whilst warm acclimation induced a d
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• Kamunde 2018 Free Radic Biol Med
  ..., respectively. The mitochondrial bioenergetic status greatly affected the rate of H₂O₂ consumption in heart but not liver mitochondr
  3 KB (465 words) - 13:30, 7 March 2020
• Teulier 2016 Proc Biol Sci
  ...ubstrates. A distant wasp species, ''Vespula vulgaris'', exhibits the same metabolic phenotype as the bumblebee, suggesting that proline oxidation is common in
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• Poole 2021 J Physiol
  ...to exercise energetics is the critical power, which occurs at a metabolic rate often far above the LT and separates heavy from very heavy/severe-intensity
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• Manko 2013 Cell Biochem Funct
  ...inate or mixture of pyruvate plus malate. Substrate-stimulated respiration rate did not depend on solution composition. In sucrose-based solution, oligomyc
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• Hanley 2005 J Physiol
  ...t J (2005) 5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids. J Physiol 562:307-18 ...tep. This creates a bottleneck for β-oxidation of fatty acids. The complex metabolic effects of 5-HD invalidate the use of 5-HD as a blocker of mitochondrial KA
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• Nuskova 2015 Abstract MiP2015
  ...ty showed no change either in the respiration or in their basal glycolytic rate. ...e stress. Generally, the threshold for defect manifestation and subsequent metabolic remodelling equals to approximately 30 % of ATPase activity.
  3 KB (441 words) - 15:54, 9 November 2016
• Lee 2018 Reprod Sci
  ...ith dichloroacetate inhibits the lactate production and oxygen consumption rate of ectopic stromal cells. In addition, hypoxia-induced PDK1 expression prev
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• Smith 2004 Proc Natl Acad Sci U S A
  ...r its evolutionary robustness and universality. The ability to enhance the rate of core reactions creates an energetic basis for selection of subsequent la
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• Timmers 2011 Cell Metab
  ...effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab 14:612-22. ...lusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
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• Wright 2013 Abstract MiP2013
  ...ific transporters in the inner mitochondrial membrane. Under conditions of metabolic dysfunction (such as insulin resistance), mitochondrial calcium homeostasis ...and the rate of glucose oxidation. The mechanism and significance of these metabolic alterations is currently under investigation.
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• Galli 2012 J Therm Biol
  ...e significantly reduced the acceptor control ratio and maximum respiration rate through all complexes of the electron transport chain. Calculated Q10 value ...'Trachemys scripta'') turtles, Acceptor control ratio, Maximum respiration rate, Electron transport chain, Q10
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• Yoshino 2021 Science
  ...olled, double-blind trial to evaluate the effect of NMN supplementation on metabolic function in postmenopausal women with prediabetes who were overweight or ob
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• Li 2016 Sci Rep
  ...te diet restriction in adulthood can reverse oxidative, cardiovascular and metabolic alterations induced by postnatal overfeeding in mice. Sci Rep 6:30817 ...m moderate CR not only normalized body weight in SL mice but also improved metabolic programming and reversed oxidative and cardiac dysfunction induced by PNOF.
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• Nuskova 2015 Abstract MiPschool London 2015
  ...isplayed a change neither in the respiration nor in their basal glycolytic rate. ...logical phenotype. At this moment, our data suggest that the threshold for metabolic remodelling equals to approximately 30 % of ATPase activity.
  3 KB (470 words) - 15:54, 9 November 2016
• Dinitrophenole
  ...Maurice Tainter as a weight loss drug due to its effect on basal metabolic rate. DNP decreases the ADP phosphorylation in mitochondria preventing the uptak
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• Cavallo 2013 PLoS One
  ...e administration to hypothyroid rats rapidly enhances fatty acid oxidation rate and bioenergetic parameters in liver cells. PLoS One 8:e52328. doi: 10.1371 ...tty acids, may contribute to understand the biochemical mechanisms of T(2)-metabolic effects.
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• Reijne 2016 PLOS ONE
  ...), the liver-specific effects of WBV may be a primary mechanism to improve metabolic health during aging, rather than that it is a consequence of alterations in
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• Kluckova 2019 FASEB J
  ...019) Succinate dehydrogenase deficiency in a chromaffin cell model retains metabolic fitness through the maintenance of mitochondrial NADH oxidoreductase functi ...ency based on epithelial cells, a chromaffin cell model retains aspects of metabolic "health," which could form the basis of cell specificity of this rare tumor
  2 KB (360 words) - 15:09, 15 January 2020
• Koch 2021 Trends Ecol Evol
  ...ing variation in performance and fitness among individuals. Whole-organism metabolic studies have provided key insights into fundamental ecological and evolutio |keywords=Bioenergetics, Life-history trade-off, Metabolic rate, Mitochondrial efficiency, Mitochondrial uncoupling, Reactive oxygen specie
  2 KB (269 words) - 18:52, 19 October 2021
• Young 2021 J Biol Chem
  ...P, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnóczky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca²⁺ signaling induced by knoc ...n makes these cells more prone to bioenergetic failure under conditions of metabolic stress.
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• Komelina 2015 Abstract MiP2015
  ...undulatus'' significant inhibition of phosphorylation rate and the maximum rate of respiration in hibernating animals in comparison with the active, using ...HM, Walpole AC, Staples JF (2006) Mitochondrial metabolism in hibernation: metabolic supression, temperature effects and substrate preferences. Physiol Biochem
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• Wei 2019 Biochem Biophys Res Commun
  ...ophylline. Collectively, our study supports that aminophylline is a potent metabolic inducer of mitochondrial biogenesis in epithelial cells. Aminophylline coul
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• Salin 2019 Proc Biol Sci
  ...cts, both on the rate of protein synthesis within these tissues and on the rate of whole-body growth of individually fed juvenile brown trout (''Salmo trut
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• Periasamy 2017 MiP2017
  ...overy after prolonged running. Our data suggests that SLN is important for metabolic flexibility especially for increased fat oxidation during high-energy deman ...Periasamy M (2015) Sarcolipin is a key determinant of the basal metabolic rate, and its overexpression enhances energy expenditure and resistance against
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• Hydrogenion flux
  ...al supply of an equivalent amount of base. The extracellular acidification rate (ECAR) is the change of pH in the incubation medium over time, which is zer ...s in the incubation buffer or culture medium. The physiologically relevant metabolic H⁺ flux, however, must not be confused with ECAR.
  4 KB (584 words) - 12:43, 1 March 2022
• Cardol 2011 Biochim Biophys Acta
  ...fying their photosynthetic electron flow capacity, by changing its maximum rate and/or by diverting photogenerated electrons towards different sinks depend
  1 KB (205 words) - 15:13, 8 August 2023
• Komlodi 2017 MiP2017
  ...signalling, which is mainly based on alterations in superoxide generation rate (further dismutated to H₂O₂) [1-3]. At sea level, the ...he highly specific Amplex UltraRed assay in MiR05 and KCl-based media. The rate of H₂O₂ generation was corrected for chemical backgro
  5 KB (734 words) - 18:54, 10 January 2022
• Vaupel MiP2010
  ...ation to mitochondrial “respiration injury” and considered this as the key metabolic change in malignant transformation (“origin of cancer cells” (3)). Warb 1. van der Heiden MG et al. (2009) Understanding the Warburg effect: The metabolic requirements of cell proliferation. Science 324: 1029-1033.
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• Cabrero 1999 Biochem Biophys Res Commun
  ...idation pathways, these results seem to implicate UCP-3 in this protective metabolic response. It remains to be studied whether reductions in the expression of
  2 KB (283 words) - 22:57, 5 July 2021
• Paeaesuke 2015 Oxid Med Cell Longev
  ...creased. Myoblasts of passage 2 cultivated from young muscle showed higher rate of OXPHOS and activities of CK and AK compared to myoblasts from older subj ...g ''in vivo'' exerts an impact on satellite cells which results in altered metabolic profile in favour of the prevalence of glycolytic pathways over mitochondri
  2 KB (334 words) - 09:40, 8 November 2016
• Andersen 2014 Abstract IOC 2014-04 Schroecken
  ...NAD to nicotinamide. Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme for recycling nicotinamide to NAD. However, evidence for th ...on of Integrative Physiology, The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen,
  3 KB (404 words) - 10:30, 9 November 2016
• Zhunussova 2016 PLOS ONE
  ...nificant progression of cell lethality. The normal prostate cells with low metabolic activity immediately responded to plasma treated PBS by suppression of resp
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• Kawalec 2015 PLoS One
  ...hondrial energy metabolism. However, we suggest a balance between negative metabolic consequences of mitofusin 2 deficiency and adaptive processes exemplified b
  2 KB (351 words) - 14:51, 13 November 2017
• Neufer 2014 Abstract MiP2014
  ...olic demand, and therefore, the relationship between OXPHOS efficiency and metabolic demand is poorly understood. O₂ consumption (high-resolution res .... Pharmacological inhibition of adenylate kinase decreased ATP production rate but did not alter ADP-dependent increases in OXPHOS efficiency.
  3 KB (342 words) - 13:04, 23 January 2019
• Kikusato 2016 Proc Jpn Soc Anim Nutr Metab
  ...al oxidative phosphorylation and reactive oxygen species generation in the metabolic modification of avian skeletal muscle. Proc Jpn Soc Anim Nutr Metab 60:57-6 ...hickens and the implication of these differences in determining the growth rate in these birds. The review also discusses the role of mitochondria as a maj
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• LaNoue 1972 J Biol Chem
  ...ial ATP:ADP ratio, and the respiratory rate were studied in five different metabolic states produced by additions of ADP, oligomycin, or uncouplers. The accumul ...mparison of succinyl-CoA levels in mitochondria incubated in the different metabolic states indicated that its content was regulated by the phosphorylation stat
  5 KB (679 words) - 17:24, 16 January 2021
• Jia 2018 Circ Res
  ...asmic reticulum stress, microvascular dysfunction, and a myriad of cardiac metabolic abnormalities have all been implicated in the development and progression o
  3 KB (330 words) - 16:09, 24 February 2020
• Pileggi 2022 EBioMedicine
  ...equately despite documented diet adherence. Patients in the bottom 20% for rate of weight loss following a hypocaloric diet (diet-resistant) have been foun ...who were previously classified in the top or bottom 20% quintiles based on rate of weight loss in the first 6 weeks during which a 900 kcal/day meal replac
  3 KB (451 words) - 19:13, 15 March 2023
• Gubert 2018 Neurotoxicology
  ...Cheng P, Bornhorst J, Trindade LS, Avila DS, Aschner M, Soares FAA (2018) Metabolic effects of manganese in the nematode ''Caenorhabditis elegans'' through DAe ...lso affected feeding behavior as evidenced by decreased pharyngeal pumping rate. DAergic neurons viability were not altered by Mn, however the dopamine lev
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• Kuznetsov 1997 Biochim Biophys Acta
  ...ary. The detailed analysis of the titration curves within the framework of metabolic control theory indicated elevated flux control coefficients of the respecti ...=Mitochondrial disease; Saponin-skinned muscle fiber; Inhibitor titration; Metabolic control analysis; Flux control coefficient
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• Cannon 2012 Abstract IOC68
  ...raining. Recently, our group have demonstrated reduced maximum respiratory rate and Complex I dysfunction using high-resolution respirometry in an animal m Piao L, Marsboom G, Archer SL (2010) Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure. J Mol Med 88: 1011
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• Quoilin 2012 Biochem Biophys Res Commun
  ...in renal oxygen consumption after LPS challenge is related to a pathologic metabolic down-regulation such as a lack of oxygen utilization by cells.
  2 KB (208 words) - 17:29, 4 June 2017
• Penniman 2019 Mol Metab
  We measured muscle insulin signaling, mitochondrial energetics, and metabolic responses to a high-fat diet (HFD) in male and female muscle-specific FoxO1 ...increases in metabolic rate. These factors mitigate fat gain and attenuate metabolic abnormalities in response to a HFD.
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• Porter 2018 MiP2018a
  ...T) was also collected to serve as a positive control. Whole body metabolic rate and sWAT morphology and UCP1 expression were quantified. sWAT respiratory c ...T was significantly correlated (r=0.77; P<0.001) with whole body metabolic rate. sWAT UCP1 function corresponded to around 3% of that of sub-platysmal BAT
  3 KB (458 words) - 08:11, 13 September 2018
• Raud 2016 Cell Metab
  ...function are independent of Cpt1a expression. Together our data argue that metabolic pathways other than LC-FAO fuel Tmem or Treg differentiation and suggest al
  2 KB (300 words) - 09:01, 6 July 2021
• Parker 2020 Thesis
  ...atment. Although there appears to be minor differences in PBMC respiratory rate between subjects with T2D and healthy controls, 10 days of isoleucine suppl
  3 KB (349 words) - 19:42, 30 July 2020
• Egnatchik 2014 Metabolism
  ...lock key events in the progression toward apoptosis. We then applied (13)C metabolic flux analysis (MFA) to quantify mitochondrial pathway alterations associate ...C MFA revealed that treatment with NAC did not normalize palmitate-induced metabolic alterations, indicating that neither elevated ROS nor downstream apoptotic
  2 KB (325 words) - 23:09, 5 July 2021
• Ghanim 2017 MiPschool Obergurgl
  ...greatly increase the comfort of patients and ideally increase the survival rate. ...to cancer cells. In particular, the research will focus on the process of metabolic transformation including aerobic glycolysis, extracellular acidification an
  3 KB (453 words) - 16:03, 12 January 2018
• Dobson 1988 Am J Physiol
  ...Parkhouse WS, Weber JM, Stuttard E, Harman J, Snow DH, Hochachka PW (1988) Metabolic changes in skeletal muscle and blood of greyhounds during 800-m track sprin ...ly. Expressed as a function of race time (48.3 +/- 0.7 s, n = 3), the mean rate of glycogen breakdown was 53.48 +/- 0.5 mumol.g wet wt-1.min-1 during the s
  2 KB (298 words) - 15:01, 17 February 2015
• Chung 2018 Integr Comp Biol
  ...pecies has faster development, more rapid growth, higher routine metabolic rate, and higher activity than the southern subspecies when compared at a common
  2 KB (350 words) - 15:37, 2 January 2019
• Hayes 2020 Nutrients
  ...a deliberate and advantageous adaptation of cancer cells to facilitate the metabolic switch between oxidative phosphorylation and aerobic glycolysis.
  3 KB (364 words) - 15:32, 2 April 2020
• Doeller 1993 J Exp Zool
  ...may be altered by environmental stresses, is unknown. In this pilot study, metabolic flux of excised gills from the marine mussel ''Mytilus edulis'' was examin
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• Docherty 2016 Stem Cell Res Ther
  ...these cells which was further confirmed by increased glucose transport. A metabolic switching effect was further emphasised by Western blot analysis where the Results from this study confirm that Lin28A expression promotes metabolic switching to a phenotype that relies predominantly on glycolysis as an ener
  2 KB (335 words) - 11:49, 24 November 2017
• Fehsenfeld 2024 Comp Biochem Physiol A Mol Integr Physiol
  ...rabs to short-term hypercapnia seems to entail the alteration of branchial metabolic pathways, possibly targeting mitochondrial cytochrome C in the gill. Our fi
  3 KB (429 words) - 19:29, 19 February 2024
• Bouillaud 2012 Abstract Bioblast
  ...dation is (1+0.5) O₂ / 2 H₂S = 0.75 and for the same rate of electron transfer three times more oxygen are needed than with NADH/FADH ...bolic processing (including for example initial ATP consuming steps). This metabolic role of sulfide and its reductant properties contrast sharply with the othe
  6 KB (835 words) - 10:26, 9 November 2016
• Meldau 2015 Abstract MiPschool Cape Town 2015
  ...ongst others. These factors contribute to the very low positive diagnostic rate in South Africa. Implementation of new measures to ensure the use of approp
  2 KB (235 words) - 12:03, 10 February 2015
• Richardson, Grassi 1999 J Appl Physiol (1985)
  ...ub>max} in trained subjects is not limited by mitochondrial metabolic rate but, rather, by O₂ supply.
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• Karavyraki 2022 MitoFit
  ...K cells. In addition, SCC-4 cells have greater extracellular acidification rate (an index of glycolytic flux) when compared to DOK cells. In addition, trea
  3 KB (405 words) - 12:38, 8 January 2023
• Polyzos 2017 Mech Ageing Dev
  ...nsitive and informative measures of the functional status MT and the cells metabolic regulation, yet these measures differ depending on the sample source; speci
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• Toleikis 2005 Biosci Rep
  ...ferent with different substrates, (iii) much higher after ischemia in both metabolic states, particularly in the case of succinate oxidation compared to pyruvat
  2 KB (233 words) - 16:18, 13 November 2017
• Afrin 2017 MiPschool Obergurgl
  ...ctivation aggravates cell survival via redox regulation for overcoming the metabolic stress [2]. Thus, the aim of the present study was to investigate the chemo ...ligomycin, 2,4-DNP and rotenone/ antimycin and extracellular acidification rate (ECAR) as an indicator of glycolysis by adding rotenone, glucose and 2-DG.
  5 KB (725 words) - 15:55, 12 January 2018
• Giulivi 2008 Biochem J
  |title=Giulivi C, Ross-Inta C, Horton AA, Luckhart S (2008) Metabolic pathways in ''Anopheles stephensi'' mitochondria. Biochem J 415:309-16. ...loacetate shuttle. Two, ASE mitochondria were able to oxidize proline at a rate comparable with that of alpha-glycerophosphate. However, the proline pathwa
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• Matallo 2014 Nitric Oxide
  ...6.2±0.2μM. Simultaneously we injected a 2mM Na2S solution at a continuous rate of 10μl/s in order to quantify the titration-time required to reduce the J
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• Bischof 2021 Sci Transl Med
  ...tivated protein kinase (AMPK)–retinoblastoma protein (Rb)-E2F axis co-opts metabolic products of MTHFD1L function to support DNA endoreplication and pathologic
  2 KB (314 words) - 19:50, 17 December 2021
• Vanweert 2020 J Clin Endocrinol Metab
  ...ma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab 106:e1827-36. ...capacity (r = -0.44, p<0.001). Consistently, whole-body leucine oxidation rate was lower in patients with T2DM vs. CON under basal conditions (0.202 ± 0.
  3 KB (378 words) - 16:04, 6 December 2021
• Thoral 2023 J Exp Biol
  ...J, Bourdeix JH, Metral L, Saraux C, Teulier L (2023) Temperature-dependent metabolic consequences of food deprivation in the European sardine. https://doi.org/1 ...nergy saving mechanisms at the mitochondrial level, whole animal metabolic rate was high during food deprivation in summer, causing increased consumption o
  3 KB (347 words) - 19:10, 15 March 2023
• Mayayo-Vallverdu 2023 Redox Biol
  ...e mice that still developed calculi. Although there were no differences in metabolic parameters or urinary cystine concentration between control and treated mic
  3 KB (415 words) - 13:53, 18 July 2023
• Heim 2017 Am J Physiol Regul Integr Comp Physiol
  ...ization, and coupling efficiency that reflected the distinct functions and metabolic demands of the tissues they support. A consistent finding across tissues wa
  3 KB (364 words) - 17:54, 22 November 2017
• Oliveira 2011 Insect Biochem Mol Biol
  ...hei infection were significantly reduced. We conclude that there are broad metabolic differences between R and S ''An. gambiae'' mosquitoes that influence their
  2 KB (231 words) - 10:03, 9 November 2016
• Van den Bergen 1994 Eur J Biochem
  ...is due to activity of the cyanide-resistant pathway. The relation between rate and Q redox state for the external NADH dehydrogenase in potato callus mito ...ons of added Q-2 used in these experiments had no detectable effect on the rate of 0₂ uptake.
  7 KB (1,023 words) - 09:03, 16 July 2021
• Ukropec 2017 MITOEAGLE Obergurgl
  ...rength training intervention in seniors with/without mild cognitive and/or metabolic impairment. ...by euglycemic hyperinsulinemic clamp, Resting Energy Expenditure (REE) and metabolic substrate preference (RQ) by indirect calorimetry (Ergostik, Geratherm). Co
  4 KB (516 words) - 15:50, 12 January 2018
• Boutoual 2018 Scientific Reports
  ...mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, ...TO1 silenced cells, we found that the MTO1 deficiency is associated with a metabolic reprogramming mediated by inactivation of AMPK, down regulation of the unco
  3 KB (381 words) - 09:22, 22 May 2019
• Karavyraki 2022 BEC
  ...K cells. In addition, SCC-4 cells have greater extracellular acidification rate (an index of glycolytic flux) when compared to DOK cells. In addition, trea
  3 KB (433 words) - 16:31, 21 January 2024
• Affourtit 1998 J Biol Chem
  ...equivalents and contributes up to 24% to the overall respiratory activity. Metabolic control analysis reveals that the alternative oxidase exerts a considerable
  2 KB (249 words) - 16:49, 18 March 2021
• Viola 2016 J Physiol
  ...n C, Hool L (2016) The L-type Ca²⁺ channel facilitates abnormal metabolic activity in the cTnI-G203S mouse model of hypertrophic cardiomyopathy. J Ph ...y be effective in reducing the cardiomyopathy by normalising mitochondrial metabolic activity.
  4 KB (517 words) - 17:11, 7 November 2016
• Calzia 2012 Abstract Bioblast
  ...olic pathway linked to the mitochondrial respiratory chain [1]. Since this metabolic process is strictly aerobic, the efficiency of sulfide metabolism is expect ...itration pump was used to simultaneously maintain the oxygen concentration rate at the predefined level adopting a previously described technique [5].
  6 KB (854 words) - 16:09, 9 November 2016
• Kwon 2009 Thesis
  ...oviding evidence that insulin action in muscle is acutely sensitive to the metabolic state of cells. A single bout of low-intensity treadmill exercise in high-f
  3 KB (500 words) - 13:28, 21 November 2018
• Amoedo 2010 Abstract MiP2010
  ...Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mi ...hat ultimately increase the rate of ATP production. These cells can suffer metabolic reprogramming, resulting in distinct bioenergetic phenotypes, generally enh
  3 KB (345 words) - 16:43, 9 November 2017
• Affourtit 1999 J Biol Chem
  ...equivalents and contributes up to 24% to the overall respiratory activity. Metabolic control analysis reveals that the alternative oxidase exerts a considerable
  2 KB (265 words) - 12:39, 3 April 2021
• Dyrstad 2015 Abstract MiPschool London 2015
  ...ation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells. ...luding fibrosis and wound healing, as well as cancer. We hypothesized that metabolic reprogramming is important to fulfill the phenotypic plasticity involved in
  4 KB (621 words) - 17:53, 9 November 2017
• El-Bacha MiP2010
  ...Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mi ...hat ultimately increase the rate of ATP production. These cells can suffer metabolic reprogramming, resulting in distinct bioenergetic phenotypes, generally enh
  3 KB (353 words) - 11:11, 17 March 2019
• Krumschnabel 2001 Gen Comp Endocrinol
  |title=Krumschnabel G, Manzl C, Schwarzbaum PJ (2001) Metabolic responses to epinephrine stimulation in goldfish hepatocytes: evidence for ...manner, which was not due to stimulated Na(+) pump activity. An increased rate of acid secretion of 50%, evoked by epinephrine, appears to be mediated by
  2 KB (238 words) - 12:05, 23 January 2019
• Quoilin 2014 Dissertation
  ...of oxygen utilization by cells for ATP production. In the long term, this metabolic disturbance leads cells to a predominantly ...on in the renal respiratory function is mainly due to an impairment in the metabolic activity of HK-2 cell mitochondria. Following LPS treatment,the oxidative p
  4 KB (581 words) - 12:21, 14 December 2015
• Ivanovic 2022 Abstract Bioblast
  ...t=Excessive lipid accumulation in hepatic cells is the hallmark of several metabolic disorders, particularly hepatic steatosis, insulin resistance (IR) and diab ...n was altered in PA treated cells, which was observed by lower respiration rate in ROUTINE and OXPHOS state and ''P-L'' control efficiency (1-''L''/''P'')
  4 KB (613 words) - 08:51, 28 July 2022
• Wefers 2018 Proc Natl Acad Sci U S A
  .... Fasting glucose and free fatty acid levels as well as sleeping metabolic rate were higher during circadian misalignment. Molecular analysis of skeletal m
  3 KB (387 words) - 10:15, 17 August 2018
• Janz 2023 Mol Metab
  ...y associated with other metabolic features. Here, we aim to understand the metabolic and pathophysiological mechanisms of mutant DNAJC19 for the development of ...s were subjected to various analyses, including assessments of morphology, metabolic function, and physiological consequences such as Ca²⁺ kinetics,
  4 KB (520 words) - 16:07, 2 January 2024
• Pineda 2018 PLoS Pathog
  ...rypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions. PLoS Pathog 14:e1007412. ...ir metabolism to grow in CMM_Glyc/GlcNAc by concomitantly increasing their rate of glycerol consumption and decreasing that of glucose. However, the glycer
  4 KB (518 words) - 13:23, 7 May 2019
• Tuena 1969 Eur J Biochem
  ...by inhibition of respiration; the further addition of ATP produced a high rate of respiration. ...to find out if ATP removed oxaloacetate through a particular ATP requiring metabolic pathway were unsuccessful.
  2 KB (282 words) - 15:07, 27 May 2020
• Nagy 2014 Abstract MiP2014
  ..., which of the compounds available in the extracellular space can serve as metabolic fuels for these cells. ...as measured with the Oroboros Oxygraph-2k, and extracellular acidification rate (ECAR) was measured on primary microglia and on the BV-2 microglial cell-li
  3 KB (403 words) - 13:04, 23 January 2019
• Lewis 2022 Methods Mol Biol
  ...s often seen in cardiovascular and cardiopulmonary diseases, diabetes, and metabolic syndrome.
  2 KB (253 words) - 11:05, 18 December 2022
• Koit 2017 Oxid Med Cell Longev
  ...o quantify the role of components of mitochondrial interactosome. The main rate-controlling steps in HBC are complex IV and adenine nucleotide transporter, ...chondria, Human breast cancer, Human colorectal cancer, Respiratory chain, Metabolic control analysis, Mitochondrial supercomplexes
  3 KB (388 words) - 18:43, 16 January 2021
• Garipi 2018 MiPschool Tromso E2
  ...ause or consequence, this hallmark of most cancer cells contributes to the metabolic shift and to changes in their microenvironment. Also, the alteration in rea ...Respirometry in order to measure mitochondrial respiration, ROS production rate and extracellular proton flux production. Esophageal cell culture models wi
  5 KB (714 words) - 13:33, 7 August 2019
• Flachs 2013 Biochim Biophys Acta
  ...ity and stimulation of lipid catabolism in white adipocytes, and improving metabolic flexibility WAT. The role of mutual interactions between adipocytes and imm
  4 KB (544 words) - 13:47, 27 April 2015
• Coelho 2015 Abstract Thyroid Cancer
  ...directly on cell proliferation and on transition from anaerobic to aerobic metabolic state. Our group showed that the activated form of AMPK (pAMPK) is overexpr ...the nontumoral NTHYori cell line. AICAR exposure further stimulated these metabolic parameters, but decreased BCPAP cell viability (4 fold), with increased (1.
  3 KB (422 words) - 15:11, 23 January 2019
• Cockova 2017 Thesis
  ...was a considerable decline in endogenous respiration, maximal respiration rate and reserve capacity. In order to obtain a more detailed view into mitochon ...uggest a considerable link between FTO activity and neuronal signaling and metabolic actions. Further research could undoubtedly prove to be beneficial in gaini
  3 KB (415 words) - 11:23, 22 January 2018
• Dias 2019 MiPschool Coimbra
  ...t metabolic endpoint of nitric oxide (•NO), has more recently emerged as a metabolic precursor of •NO ''in vivo''. This alternative source of •NO may play a ...control (no nitrite) conditions, a significant increase in the respiration rate is observed upon re-oxygenation (“oxidative burst”), in the presence of
  3 KB (406 words) - 18:07, 12 July 2019
• Camacho-Pereira 2013 Abstract IOC75
  ...et-induced obesity indicating that CD38-/- animals have a higher metabolic rate compared to wild-type mice (WT) [3]. As a regulator of NAD levels, CD38 can ...a regulator of cellular NAD: a novel potential pharmacological target for metabolic conditions. Curr Pharm Des 15: 57-63.
  4 KB (574 words) - 17:09, 9 November 2017
• Vera Vives 2022 MitoFit
  ...oblast]] The rate of oxygen evolution provides valuable information on the metabolic status and the photosynthetic performance of a cell, and it can be quantifi
  2 KB (318 words) - 10:29, 12 March 2024
• Montaigne 2013 J Am Coll Cardiol
  ...were quantified in right atrial tissue from 104 consecutive patients with metabolic syndrome, in sinus rhythm, and undergoing coronary artery bypass graft surg ...associated with AF onset after adjustment for age, body mass index, heart rate, beta-blocker use, and statin medication (multivariate logistic regression
  3 KB (388 words) - 15:25, 13 November 2017
• Rolfe 1994 Biochim Biophys Acta
  ...d that proton leak could be a significant contributor to resting metabolic rate in mammals if it were present in other tissues. Mitochondria were isolated
  2 KB (269 words) - 12:36, 24 November 2022
• Varikmaa 2013 Thesis
  ...is puzzying discovery has obscured the understanding of how ATP production rate in mitochondria is matched with its turnover in cytosol. significantly lower (~50% decline in respiration rate upon PK/PEP addition) in
  5 KB (658 words) - 08:23, 20 October 2017
• Cotoia 2014 PLoS One
  ...is on cultured EA.hy 926 cells demonstrated that pHPP improved cell growth rate and promoted cell survival under stressing conditions. Moreover, pHPP stimu
  2 KB (259 words) - 17:26, 9 November 2017
• Zeng 2017 J Biol Chem
  ...effective approach for the treatment of high fat diet- or obesity-induced metabolic diseases by improving mitochondrial lipid and ROS metabolism.
  2 KB (251 words) - 15:38, 28 March 2018
• Calderon-Dominguez 2017 Adv Sci (Weinh)
  ...light on its potential as a therapeutic target in the treatment of several metabolic conditions including obesity and diabetes. To date the measurement of bioen ...ords=Bioenergetics, Brown adipose tissue, Mitochondria, Oxygen consumption rate
  2 KB (282 words) - 15:57, 27 March 2018
• Vera-Vives 2022 BEC
  The rate of oxygen evolution provides valuable information on the metabolic status and photosynthetic performance of a cell, and it can be quantified b
  2 KB (321 words) - 14:11, 17 August 2023
• Wieser 2001 Biochem J
  ...ells in an FAA-enriched medium, secondly, that the attempt to estimate the metabolic cost of protein synthesis by inhibiting oxygen consumption with cycloheximi
  4 KB (522 words) - 12:08, 23 January 2019
• Nukala 2006 J Neurosci Methods
  ...tunity to store mitochondria for longer periods of time as well as perform metabolic studies as needed. This will considerably expand the time-frame required fo
  2 KB (282 words) - 15:30, 13 November 2017
• Lee 2017 MiP2017
  ...difference of mitochondrial genome and its association with phenotypes of metabolic syndrome. [[Media:Lee_Presentation_Hradec_Kralove.pdf|Lee_Presentation]] ...ink=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] Metabolic syndrome (MetS) was created cluster state of risk factors for atheroscleros
  5 KB (755 words) - 17:37, 25 February 2020
• Alves 2018 MiPschool Tromso E2
  ...with combined mTOR and SIRT1 inhibitors, this is a first assessment of the metabolic and bioenergetics profile of these cells. Further studies will be needed to
  5 KB (660 words) - 18:01, 23 February 2020
• Jacobus 1985 Annu Rev Physiol
  ...Overall, heart creatine kinase may be a unique example of "kineto-dynamic" metabolic integration.
  2 KB (316 words) - 08:40, 6 July 2022
• Dias 2023 Biofactors
  ...of hippocampal tissue with high K⁺ significantly increased the rate of oxidative phosphorylation, which was accompanied by a transient decrease
  2 KB (306 words) - 15:39, 19 December 2023
• Aisenberg 1961 Academic Press
  :::## Metabolic inhibitors of glycolysis :::## The over-all respiratory rate of the tumor slice
  2 KB (322 words) - 11:27, 23 September 2021
• Bikman 2022 Eur J Clin Nutr
  ...lton CM, Ebbeling CB, Ludwig DS (2022) A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration. https://doi.org/10.1038/s41430 |abstract=Adipocyte mitochondrial respiration may influence metabolic fuel partitioning into oxidation versus storage, with implications for whol
  2 KB (257 words) - 10:51, 5 December 2022
• Leithner 2014 J Cereb Blood Flow Metab
  ...ly, CBF increases surpass the accompanying increases of cerebral metabolic rate of oxygen (CMRO2). However, a disproportionate CBF increase may be required
  2 KB (291 words) - 23:40, 18 December 2022
• Amoedo 2011 PLoS One
  ...glycolysis channeled to lactate production. In the present work we showed metabolic reprogramming by means of inhibitors of histone deacetylase (HDACis), sodiu
  3 KB (426 words) - 16:43, 9 November 2017
• Aid-Vanakova 2019 MiP2019
  ...ith impaired glucose tolerance and an activated pathway characteristic for metabolic diseases [3]. ...rates with succinate were unaffected by Wfs1 deficiency. It indicates to metabolic alterations in supporting of OXPHOS at the level of complex I.
  5 KB (679 words) - 09:31, 2 September 2019
• Castelein 2014 Exp Gerontol
  ...ous findings established that culture in axenic medium increases metabolic rate. We asked whether axenic culture induces changes in mitochondrial functiona
  2 KB (277 words) - 17:12, 9 November 2017
• Krajcova 2016 Abstract MitoFit Science Camp 2016
  ...]. The symptoms can occur in various combinations and include: unexplained metabolic acidosis, arrhythmia, Brugada like pattern on electrocardiograph (elevated ...0 µg/ml) was assessed by Oroboros Oxygraph-2k. Firstly, oxygen consumption rate (OCR) was measured at baseline, after addition of ATPase inhibitor and subs
  5 KB (679 words) - 15:19, 23 January 2019
• Lee 2018 Neurol Genet
  ...ies production was increased, which correlated with an increased metabolic rate.
  2 KB (284 words) - 16:08, 30 October 2018
• Alexandre 2017 Conserv Physiol
  ...udden temperature variation, significantly reducing the oxygen consumption rate up to a seven-fold change. Fish quickly returned to initial swimming costs
  2 KB (313 words) - 17:55, 22 November 2017
• Pamenter 2018 PLoS One
  |abstract=Therapeutic hypothermia is a strategy that reduces metabolic rate and brain damage during clinically-relevant hypoxic events. Mitochondrial r
  2 KB (288 words) - 11:26, 29 July 2019
• Hernandez-Mijares 2011 Free Radic Biol Med
  ...study supports the hypothesis of an association of type 2 diabetes and the rate of impaired mitochondrial function. We also propose that one of the targets
  2 KB (289 words) - 16:10, 9 November 2016
• Morosinotto 2022 Abstract Bioblast
  |abstract=The rate of oxygen evolution provides valuable information on the metabolic status and the photosynthetic performance of a cell, and it can be quantifi
  2 KB (302 words) - 08:30, 28 July 2022
• Gnaiger 1998 Biochim Biophys Acta
  ...lative to the Electron transfer-pathway and a correspondingly low turnover rate of this enzyme, consistent with the concept of kinetic trapping of oxygen [ ...d read: "''p''<Sub>50</Sub> was dependent on respiratory rate, but also on metabolic state".
  4 KB (505 words) - 16:27, 24 April 2023
• Krumschnabel 1996 Am J Physiol
  |title=Krumschnabel G, Biasi C, Schwarzbaum PJ, Wieser W (1996) Membrane-metabolic coupling and ion homeostasis in anoxia-tolerant and anoxia-intolerant hepat ...production was reduced to 15% and Na+ pump activity to 22% of the control rate under normoxia. Measurement of the cellular ATP content under these conditi
  2 KB (336 words) - 12:05, 23 January 2019
• Nuskova 2011 Abstract IOC61
  ...ce the p50 value of the KO cells was approximately 2-fold increased in all metabolic states measured, the oxygen affinity of COX was also decreased.
  3 KB (493 words) - 14:34, 26 March 2018
• Power 2014 Abstract MiP2014
  ...(Δ''Ψ''_mt; using safranine) ''in vitro'', using a comprehensive metabolic substrate complement with isolated mitochondria [2]. ...working rat hearts showed breakpoints in all functional parameters (heart rate, cardiac output and ventricular contractility) at ~40.5 °C. Relative to 37
  3 KB (483 words) - 13:13, 16 June 2015
• Lemieux 2006 Biochim Biophys Acta
  ...ysiological temperature, using 0.7 mg wet weight of muscle biopsy; and (3) metabolic shutdown of the heart is extensive at 4 °C but incomplete. The present dat
  3 KB (453 words) - 18:14, 10 January 2022
• Shick 1988 Amer Zool
  ...is little evidence for energy supplementation such as increases in feeding rate or absorption efficiency. Ammonia production continues during aerial exposu
  2 KB (331 words) - 23:16, 15 July 2022
• Staples 2013 Abstract MiP2013
  |title=Staples JF(2013) Mechanisms of mitochondrial metabolic suppression in hibernation. Mitochondr Physiol Network 18.08. ...study plasticity of many physiological functions, including mechanisms of metabolic regulation.
  4 KB (553 words) - 11:24, 28 April 2017
• Kunz 1999 J Neurochem
  |title=Kunz WS, Kuznetsov AV, Clark JF, Tracey I, Elger CE (1999) Metabolic consequences of the cytochrome c oxidase deficiency in brain of copper-defi ...ol coefficients of NADH:CoQ oxidoreductase and cytochrome c oxidase on the rate of mitochondrial respiration. Application of amobarbital to titrate the act
  2 KB (316 words) - 14:52, 28 March 2018
• Giovarelli 2023 Mol Med
  ...ct=High-resolution respirometry (HRR) of human biopsies can provide useful metabolic, diagnostic, and mechanistic insights for clinical research and comparative By this protocol, Oxygen Consumption Rate (OCR) measurements of fresh and cryopreserved placental specimens are compa
  2 KB (300 words) - 15:50, 17 May 2023
• Batra 2022 Abstract Bioblast
  ...n and induced apoptosis. Further, DAP reduced extra cellular acidification rate in prostate cancer cells. In addition, lactoferrin conjugated DAP particle
  4 KB (468 words) - 08:43, 28 July 2022
• Chang 2015 Abstract EB2015
  |abstract=Mitochondrial biogenesis is a critical metabolic adaptation to aerobic exercise training. What kind of the exercise strategy ...MCT regimens significantly increased ATP-linked O₂ consumption rate (OCR), elevated reserve capacity of OCR, and lowered non-mitochondrial OCR
  2 KB (284 words) - 14:15, 2 March 2020
• Ruas 2018 Sci Rep
  ...cin on CCCP-induced _maxOCR did not occur when glutamine was the metabolic substrate or when the glycolytic inhibitor 2-deoxyglucose was present. ATP
  2 KB (332 words) - 14:29, 12 June 2022
• Petit 2017 MiPschool Obergurgl
  ...he entry of the TCA cycle suggests that FAHD1 plays an important role as a metabolic regulator. The role of FAHD1 in mammalian cells remained elusive. In the pr ...it was found that FAHD1 depleted HUVEC had a decreased oxygen consumption rate (Figure 1 E). In addition, depletion of FAHD1 in the breast cancer cell lin
  8 KB (1,147 words) - 14:10, 26 March 2018
• Kaldma 2014 Int J Biochem Cell Biol
  ...lterations in the expression of HK-1 and HK-2 isoforms have been observed. Metabolic control analysis showed that the distribution of the control over electron |keywords=Energy metabolism, Metabolic control analysis, Colorectal cancer, Mitochondria, VDAC, Hexokinase, Tubuli
  3 KB (502 words) - 08:23, 20 October 2017
• Boveris 1973 Biochem J
  |abstract=1. Pigeon heart mitochondria produce H(2)O(2) at a maximal rate of about 20 nmol/min per mg of protein. ...by pigeon heart mitochondria in the presence of succinate-glutamate and in metabolic [[State 4]] has an optimum pH value of 7.5. In States 1 and 3u, and in the
  3 KB (488 words) - 21:35, 13 April 2022
• Richmond 1999 Am J Physiol
  ...ro, possibly due to differing local conditions rather than a difference in metabolic set point for the mitochondria.
  2 KB (346 words) - 23:16, 15 July 2022
• Schulte 1992 J Exp Biol
  |title=Schulte PM, Moyes CD, Hochachka PW (1992) Integrating metabolic pathways in post-exercise recovery of white muscle. J Exp Biol 166:181-95. ...o the resting values. The resulting high [ATP]/[ADP]f ratios may limit the rate at which white muscle mitochondria can produce ATP to fuel glycogenesis in
  2 KB (309 words) - 09:13, 9 November 2016
• Dias 2016 Neurobiol Aging
  ...rgy metabolism revealed age-dependent decrease in basal oxygen consumption rate, a general decrease in mitochondrial oxidative phosphorylation parameters,
  2 KB (289 words) - 18:05, 12 July 2019
• Wuest 2018 MiP2018a
  ...chondrial biogenesis, or (2) 100 μM etomoxir – a powerful inhibitor of the rate controlling enzyme carnitinepalmitoyl transferase 1 (CPT1) - to reduce the ::::#Lab Genetic Metabolic Diseases
  4 KB (541 words) - 08:16, 13 September 2018
• Gnaiger 1998 J Exp Biol
  ...er excess capacity of COX in heart. This yields, in turn, a lower turnover rate of COX even at maximum flux through the Electron transfer-pathway, which is
  4 KB (588 words) - 16:42, 24 April 2023
• Vulczak 2020 Cells
  ...e antitumorigenic effects of physical exercise, particularly regarding the metabolic transformations in TNBC.
  2 KB (302 words) - 16:43, 26 September 2022
• Jastroch 2010 Essays Biochemistry
  ...The basal proton leak is cell-type specific and correlates with metabolic rate. The inducible leak through the adenine nucleotide translocase (ANT) and un
  2 KB (339 words) - 16:43, 5 March 2019
• Barkova 2023 MiP203
  ...(n=15). Body composition, glucose tolerance, insulin sensitivity and other metabolic parameters were assessed. Samples of m. vastus lateralis obtained by biopsy ...hropometric (increased BMI by ~ 8 % and visceral fat content by ~ 36%) and metabolic parameters was observed, together with a reduction in muscle mitochondrial
  4 KB (456 words) - 16:37, 12 July 2023
• Mishra 2014 Invest Ophthalmol Vis Sci
  sequence variants, decrease in respiration rate and increase in apoptosis, overexpression of ...rds=Diabetic retinopathy, DNA repair, Mitochondria damage, mtDNA mismatch, Metabolic memory
  3 KB (345 words) - 12:08, 15 December 2015
• Abdel-Rahman 2015 Abstract MiPschool Cape Town 2015
  ...he same sample. Although we didn't detect sex-dependent discrepancy in the rate of hydrogen peroxide production by Nox in isolated synaptosomes, the HRP/Am #Ali SS, Marcondes MG, Bajova H, Dugan LL, Cont B (2010) Metabolic depression and increased reactive oxygen species production by isolated mit
  4 KB (519 words) - 13:14, 23 January 2019
• Serna 2020 J Bioenerg Biomembr
  ...he absence of ATP synthesis, lower maximal respiratory rates and a reduced rate of hydrogen peroxide release. Hydrogen peroxide release was unaltered by CR
  2 KB (328 words) - 13:18, 27 October 2020
• Moyes 1989 J Exp Biol
  ...ance. Whereas RM mitochondria appear to be able to utilize a wide range of metabolic fuels (fatty acids, pyruvate, amino acids but not ketone bodies), WM mitoch
  2 KB (298 words) - 09:34, 8 November 2016
• Hand 2013 Abstract MiP2013
  ...hypometabolism termed diapause [1]. Metabolism as measured by respiration rate declines by over 99% during entry into diapause across a 26-day time course ...racellular pH of A. franciscana embryos may decline during diapause as the metabolic depression phase progresses.
  4 KB (563 words) - 14:30, 13 November 2017
• Dikova 2020 Free Radic Biol Med
  |title=Dikova V, Vorhauser J, Geng A, Pelster B, Sandbichler AM (2020) Metabolic interaction of hydrogen peroxide and hypoxia in zebrafish fibroblasts. Free ...nse was accompanied by a transient increase in extracellular acidification rate (ECAR) and a lower cellular reducing potential as assessed by the viability
  2 KB (337 words) - 10:09, 31 May 2023
• Penna 2016 Abstract Mito Xmas Meeting Innsbruck
  ...0B decrease mitochondrial membrane potential and O₂ consumption rate (OCR). Overall, this work describes a novel mitochondrial protein that, unl
  2 KB (337 words) - 17:02, 14 December 2016
• Kim MiP2010
  ...Ha SH, Kim N, Han J (2010) BH4 deficiency involved in cardiac mitochondria metabolic pathway remodelling. MiP2010. ...ondrial membrane potential (ΔΨmt) depolarization, mitochondria respiration rate inhibition and mitochondrial DNA fragmentation. These findings suggest new
  2 KB (312 words) - 15:45, 28 March 2018
• Bastian 2016 Cancer Lett
  ...a target for AG311 was further established by measuring oxygen consumption rate in tumor tissue isolated from AG311-treated mice. Cotreatment of cells and
  2 KB (310 words) - 09:30, 23 December 2016
• Jennings 1981 Circ Res
  ...vo. HEP utilization and production during ischemia were estimated from the rate of accumulation ...make total ischemia well suited to the study of relationships between the metabolic,
  3 KB (400 words) - 08:40, 16 June 2015
• Tunholi 2016 J Invertebr Pathol
  ...ates in the infected snails. The possible mechanisms that explain this new metabolic condition in the infected organisms are discussed.
  2 KB (322 words) - 16:19, 13 November 2017
• Coelho 2016 Oncol Rep
  ...glycolysis efficiency, when compared to NTHY-ori, as assessed by a higher rate of glucose consumption and lactate production. The BCPAP cell line presente
  2 KB (350 words) - 14:52, 4 October 2018
• Dias Candida
  ...control conditions (no nitrite), a significant increase in the respiration rate is observed upon re-oxygenation (“oxidative burst”), in the presence of
  4 KB (514 words) - 11:09, 18 March 2020
• Heerlein 2005 Am J Respir Cell Mol Biol
  ...hypoxia. ATP was decreased 30% after 24-h hypoxia, but lactate production rate was not affected. Reduced nicotinamine adenine dinucleotide was slightly el
  2 KB (348 words) - 10:46, 9 November 2016
• Phillips 2017 Cancer Research
  ...expression vector (pReceiver-Lv103, GeneCopoeia™) in NCM356 cells. Global metabolic profiling (Metabolon, Durham) was performed on cellular extracts from NCM36 ...that CBS-hi cells exhibited a significant increase in maximum respiration rate, reserve respiratory capacity and increased citrate synthase activity, sugg
  4 KB (487 words) - 08:52, 11 July 2017
• Genova 2018 MiP2018
  ...ned by simultaneous addition of NADH and succinate is much higher than the rate predicted for a single homogeneous CoQ10 pool. However, when the pressure b
  4 KB (612 words) - 09:43, 20 August 2018
• Konczal 2015 Mol Biol Evol
  |keywords=RNA-Seq, Bank vole, Mammals, Maximum metabolic rate, Selection experiment, Standing genetic variation
  3 KB (364 words) - 11:25, 14 July 2016
• Hoppel 2012 Abstract Bioblast
  The rate of ATP production is directly determined using an amino acid and a fatty ac ...tive machinery. Six different fatty acid substrates are used to assess the metabolic pathways in fatty acid oxidation. Mitochondrial membrane integrity is direc
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• Bufe 2017 TRACT PhD project abstract
  |title=Metabolic profiles in normal, dysplastic and cancerous oral cells. ...eal cancer (OC) the odds are bad, which could be told by a 5-year survival rate of only about 18%. Furthermore, the number of new cases and deaths did not
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• Ackerly 2023 Comp Biochem Physiol A Mol Integr Physiol
  ...aerobic swimming performance in the absence of improved maximum metabolic rate following hypoxia acclimation.
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• Salazar-Petres 2022 Biol Reprod
  ...to changes in the expression of hormone-responsive (androgen receptor) and metabolic signaling (AMPK, AKT, and PPARγ) pathways. Thus, in normal mouse pregnancy
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• Amoedo 2013 Abstract MiP2013
  ...carcinogenesis is guided by gene expression regulation that promote these metabolic changes in a different and complex way for each cancer cell, thus, the ener ...ation); non-metastatic 4C11- and metastatic 4C11+ melanoma cell lines. The metabolic profile of each of these different cell lines was investigated by evaluatin
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• Widlund 2014 Abstract MiP2014
  ...p-regulated by Resv, which also is observed on extracellular acidification rate. To further evaluate if mitochondria of HeLa WT and HeLa Rho 0 cells were a ...J (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 127: 1109-22.
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• Corpeleijn 2010 Am J Physiol Endocrinol Metab
  ...ng respiratory quotient of all subjects (''P'' < 0.02). In conclusion, the rate of ICL(OX) is dependent on the availability of extracellular fatty acids an
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• Poddar 2016 Abstract IOC116
  ...brain mitochondrial functions were assessed in terms of oxygen consumption rate, transmembrane potential, ATP synthesis and respiratory chain complex activ
  2 KB (344 words) - 20:02, 20 November 2016
• Rebane-Klemm 2020 Cancers (Basel)
  ...To conclude, prognostic biomarkers KRAS and BRAF are likely related to the metabolic phenotype in CRC and polyps. Assessment of the tumor mitochondrial ATP synt
  2 KB (357 words) - 16:51, 6 April 2020
• Maedo 2014 Abstract IOC 2014-04 Schroecken
  ...≈ 120µM). At the same time there was 1.75 times higher maximal respiration rate in tumor samples compared to controls, suggesting cancer`s enhanced respira
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• Puskarich 2016 J Crit Care
  ...n and the association of these changes with clinical outcomes and systemic metabolic function. maximal respiratory rate after serial titrations of carbonyl cyanide 4-(trifluoromethoxy) phenylhydr
  3 KB (353 words) - 12:17, 16 September 2021
• Hoppel 2016a Abstract MitoFit Science Camp 2016
  ...In addition using spectroscopy and the freshly isolated mitochondria, the rate of ATP production is directly determined using an amino acid, glutamate & m ...ifferent fatty acid substrates are used to assess the varied and exclusive metabolic pathways in fatty acid oxidation. Mitochondrial membrane integrity is dire
  4 KB (546 words) - 15:34, 20 October 2017
• Sobotka 2017 MiPschool Obergurgl
  ...upler inhibitor titration (SUIT) protocols allow us to study mitochondrial metabolic pathways and the electron transport system in various physiological and pat ...athway. Therefore during ROS measurement the question is not only what the rate of this ROS production is, but also its site. Considering this critical iss
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• Jung 2012 J Med Food
  ...KME treatment significantly increased the mitochondrial oxygen consumption rate (OCR) in L6 cells and increased the expression of peroxisome proliferator
  3 KB (366 words) - 09:11, 27 January 2020
• Rodrigues-Ferreira 2012 J Bioenerg Biomembr
  ...e effects of the alkylating agent 3-BrPA on the respiratory states and the metabolic steps of the mitochondria of mice liver, brain and in human hepatocarcinoma
  3 KB (370 words) - 14:23, 9 November 2016
• Power 2014 Physiol Rep
  ...t of the Leak O2 flux and this did not significantly affect ATP production rate. Therefore, during mild hyperthermia (40°C) there is no enhancement of ATP
  3 KB (365 words) - 15:40, 17 January 2023
• Lim 2009 PlosOne
  ...ated mitochondria. Chronic administration of ATZ decreased basal metabolic rate, and increased body weight, intra-abdominal fat and insulin resistance with
  3 KB (364 words) - 17:25, 25 February 2020
• Johansen 2019 Comp Biochem Physiol C Toxicol Pharmacol
  ...n oil induced decoupling of swim performance (Ucrit) and maximum metabolic rate (MMR) whereby oil causes a decline in Ucrit without a parallel reduction in
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• Rivas 2018 Am J Physiol Endocrinol Metab
  ...ut not E subjects ( P = 0.68). Both groups exhibited reduced resting heart rate (Δ30 ± 23 beats/min, P ≤ 0.02). These data indicate that short-term
  3 KB (373 words) - 08:14, 21 February 2020
• Nicolaisen 2020 FASEB J
  ...c underpinnings of TRα₁ -linked control of whole-body metabolic rate. Together, this work establishes a fundamental role for skeletal muscle in
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• Steffen 2023 J Exp Biol
  ...limation to low salinity increased mitochondrial oxidative phosphorylation rate and coupling efficiency and stimulated mitochondrial respiration after acut
  3 KB (379 words) - 18:14, 25 July 2023
• Cordero-Reyes 2014 J Mol Cell Cardiol
  ...ergy starvation in the failing heart may be the result of dysregulation of metabolic pathways, impaired substrate supply or reduced mitochondrial number but not ...tate 3 respiration to the uncoupled rate, state 4 respiration to uncoupled rate, subsarcolemmal mitochondria, succinate
  4 KB (532 words) - 17:25, 9 November 2017
• Lee 2017 MiPschool Obergurgl
  |title=[[File:LeeHK.jpg|left|90px]] The metabolic syndrome (MetS) - dysmitochondrial syndrome and mitochondrial disruptors. [ ...docrine disrupting chemicals (EDCs), persistent organic pollutants (POPs), metabolic disrupting chemicals (MDCs).
  5 KB (649 words) - 16:10, 12 January 2018
• Heim 2016 Thesis
  ...l (''Callospermophilus lateralis''; GMGS), cease to feed, reduce metabolic rate, and lower body temperature (Tb) during the winter months, surviving almost
  3 KB (442 words) - 13:54, 31 July 2017
• Yang 2010 Cancer Biol Ther
  ...ion of glycolysis with iodoacetic acid reduced ATP levels at a much faster rate in H-Ras^Q61L transformed cells than in the vector control cells.
  3 KB (399 words) - 17:34, 29 February 2020
• Holzknecht M
  ...c metabolism will be provided by measuring the extracellular acidification rate (ECAR). ...nvestigating mRNA levels (qPCR) of selected genes that are involved in the metabolic shift from glycolysis (early development) to oxidative phosphorylation (adu
  5 KB (671 words) - 10:48, 7 January 2020
• Boushel 2014 Acta Physiol (Oxf)
  ...this study was to investigate the relative roles of circulatory and muscle metabolic mechanisms by which prolonged low-intensity exercise training alters region ...ore and after 42 days of skiing for 6 h.day^-1 at 60 % max heart rate.
  4 KB (552 words) - 13:38, 22 May 2022
• Conley 2013 J Clin Endocrinol Metab
  |abstract=This study investigated the disparity between muscle metabolic rate and mitochondrial metabolism in human muscle of sedentary vs. active indivi
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• Schoepf 2016 Abstract Androgens 2016
  ...tions in BE and CA tissue revealed a significantly higher overall mutation rate in malignant tissue. Most interestingly, deleterious mutations in regions c
  3 KB (356 words) - 18:40, 10 January 2022
• Victorino 2015 Tumour Biol
  ...PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol 37:6035-44. ...compared to a non-tumorous breast cell (MCF-10A) and higher proliferation rate. PGC-1β expression was knocked down with short interfering RNA in HER2-ove
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• Mitroshina 2019 Oxid Med Cell Longev
  ...oxic injury. At a concentration of 1 ng/ml, GDNF maintained the functional metabolic network activity in primary hippocampal cultures and preserved the structur
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• Shevchuk 2015 Abstract MiP2015
  ...stand the mechanisms by which a given enzyme exerts high or low control of metabolic flux and how the control of the pathway is shared by several pathway enzyme ...etermine the flux control coefficients (FCC), the flux was measured as the rate of O₂ consumption by permeabilized tissue fibers derived from CR
  7 KB (1,016 words) - 14:53, 23 January 2019
• Pinho 2019 MiPschool Coimbra
  ...MiPsocietyLOGO.JPG|left|90px|Mitochondrial Physiology Society|MiPsociety]] Metabolic remodeling and susceptibility to stress after forcing OXPHOS in human skin ...urements of oxygen consumption rates (OCR) and extracellular acidification rate (ECAR) using a Seahorse XFe96 Analyzer and quantified mitochondrial network
  4 KB (564 words) - 08:45, 26 June 2019
• Devaux 2015 Abstract MiP2015
  ...adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression. ...e to hypoxia or anoxia while the grey carpet shark maintains its metabolic rate but releases additional red blood cells to prolong survival. Mitochondria i
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• Viana 2019 Sci Rep
  ...56 tumour metabolism to a less glycolytic phenotype profile in which these metabolic alterations were associated with a decrease in tumour aggressiveness and re
  3 KB (373 words) - 11:47, 4 November 2019
• Went 2021 Batchelor thesis
  ...Doerrier et al 2018; Gnaiger 2020). Real-time net O₂ production rate (net photosynthesis ''NP'') was measured with the NextGen-O2k. Light intens
  3 KB (413 words) - 10:56, 3 August 2022
• Gstraunthaler 1999 Cell Physiol Biochem
  ...mpact of culture conditions, culture media volumes, and glucose content on metabolic properties of renal epithelial cell cultures. Are renal cells in tissue cul .../Impact-of-culture-conditions-culture-media-volumes-and-glucose-content-on-metabolic-properties-of-renal-epithelial-cell-cultures-Are-renal-cells-in-tissue-cult
  6 KB (876 words) - 19:00, 5 June 2022
• Oliveira HC 2013 Abstract MiP2013
  ..., Vercesi AE (2013) Intermittent fasting improves oxidative stress but not metabolic disturbances and atherosclerosis in hypercholesterolemic mice. Mitochondr P ...lity of VLDL to oxidation (increased lag time to oxidation by 25%) and the rate of liver mitochondrial ROS generation (decreased in DCF oxidation by 43%).
  3 KB (368 words) - 11:20, 28 April 2017
• Sparks 2014 Abstract MiP2014
  ...bolic adaptation in mice require NAMPT [2]. The mechanisms responsible for metabolic adaption are unclear. We hypothesized that muscle-specific overexpression o ...n-mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. J Gerontol A Biol Sci Med Sci 69: 44-57.
  5 KB (725 words) - 10:18, 8 November 2016
• Morrow 2017 Proc Natl Acad Sci U S A
  ...ate of mitochondrial oxidation of calories is important in the etiology of metabolic disease.
  3 KB (373 words) - 18:54, 16 January 2021
• Schmidt 2021 J Biol Chem
  ...level phosphorylation via glycolysis (i.e. via extracellular acidification rate (ECAR)). Though these technologies have demonstrated substantial utility an
  6 KB (833 words) - 12:11, 27 March 2023
• Bailey 2009 Am J Physiol Regul Integr Comp Physiol
  ...S100beta and both global cerebral oxidative metabolism (cerebral metabolic rate of oxygen) and neuronal integrity (NSE) were preserved (P > 0.05 vs. normox
  3 KB (374 words) - 16:19, 3 February 2022
• Porter 2016 J Burn Care Res
  ...olism was determined by the difference in predicted and measured metabolic rate. Mitochondrial respiration was determined in saponin-permeabilized myofiber
  3 KB (351 words) - 22:21, 1 August 2018
• Raji 2016 J Alzheimers Dis
  ...us, and site. Multiple comparisons were controlled using a False Discovery Rate of 5 percent. ...ctors [7, 8]. First, they are associated with increased cardiovascular and metabolic risk factors, such as diabetes, hypertension, and obesity [9], which are as
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• Nagwani 2023 MiPschool Obergurgl
  ...c magnetic field with an intensity <5 μT), which is known to influence the metabolic processes including mitochondria functioning. However, very few studies con ...to be more sensitive to HMF than females that correlated with the survival rate. The results provide an insight into mechanisms of HMF effect that could be
  3 KB (445 words) - 16:08, 28 June 2023
• Iyer 2022 Abstract Bioblast
  ...'L''. The glycoBHI was based on four key aspects of cellular proton efflux rate linked to glycolysis [3]. ...ochondrial ATP synthesis rate was decreased while glycolytic ATP synthesis rate was elevated in diseased cell lines.
  6 KB (863 words) - 16:22, 20 June 2022
• Anderson 2011 Am J Physiol Heart Circ Physiol
  ...propensity for mitochondrial-dependent cell death, possibly as a result of metabolic stress-imposed changes that have occurred within the mitochondria, renderin
  3 KB (448 words) - 16:40, 14 October 2019
• Porter 2022 Abstract Bioblast
  ...K cells. In addition, SCC-4 cells have greater extracellular acidification rate (an index of glycolytic flux) when compared to DOK cells. In addition, trea
  3 KB (428 words) - 08:40, 28 July 2022
• Ng 2019 J Biol Chem
  ...respiration at complex II, possibly indicating mitophagy or an alternative metabolic route, respectively. In summary, our results provide insights relevant for
  3 KB (404 words) - 12:15, 9 July 2019
• Zhang 2018 IBEC
  ...or activity measurements are obtained using a Promethion Mouse Multiplexed Metabolic System(Sable Systems International, Las Vegas, NV).Mitochondrial Respiratio ...as determined by insulin tolerance test. Our findings also showed cellular metabolic changes during muscle atrophy and sarcopenia may induce higher production o
  5 KB (676 words) - 03:20, 1 March 2020
• MiP2017/MitoEAGLE Hradec Kralove CZ
  ...nce on Mitochondrial Physiology: The role of mitochondria in lifestyle and metabolic syndrome - COST MitoEAGLE perspectives and MitoEAGLE WG and MC Meeting. ...ocal costs (accommodation with 70€/night flat rate and meals with 20€ flat rate) and travel expenses.Registration fees can not be reimbursed.
  6 KB (876 words) - 08:52, 29 July 2022
• Bettinazzi 2022 Abstract Bioblast
  ...hermal niches. In addition, temperature and dietary regimes are well-known metabolic stressors whose variation can potentially exacerbate mitonuclear incompatib ...ower H₂O₂ efflux. The high mitochondrial respiration rate also links with a trend of higher locomotor activity, but with lower fecund
  3 KB (450 words) - 08:47, 28 July 2022
• Li 2018 IBEC
  ...ochondrial unfolded protein response (UPRmt) and mitophagy, in response to metabolic stresses. ...ochondrial State 3 (ST3), State 4(ST4) respiration and respiration control rate (RCR). JC-1 probe was used to measure mitochondrial membrane potential. Wes
  3 KB (464 words) - 04:41, 21 November 2023
• Crabtree 1929 Biochem J
  ...ing growth, efficiency of blood supply, and the generally higher metabolic rate of the mouse as compared with larger animals.
  4 KB (557 words) - 10:38, 6 July 2022
• Chowdhury 2012 Brain
  ...larization in axons. The bioenergetics profile (maximal oxygen consumption rate, coupling efficiency, respiratory control ratio and spare respiratory capac
  3 KB (422 words) - 08:23, 21 February 2020
• Mendham 2015 Abstract MiPschool Cape Town 2015
  ...football-based small-sided games (SSG), which has been reported to improve metabolic health in clinical populations [3]. Accordingly, this study aimed to assess ...min exercise bouts (CYC and SSG) in a randomized, cross-over order. Heart rate (HR) and Rating of Perceived Exertion (RPE) were collected during each bout
  4 KB (604 words) - 11:43, 25 February 2015
• Duchen 2012 Abstract Bioblast
  ...of ~2.7ns). It is also apparent that lifetimes vary depending on cellular metabolic state, but the biochemical basis for those variations in lifetime has not b ...ADPH lifetimes in cells in culture under a variety of carefully controlled metabolic conditions. Lifetimes were measured using a Becker and Hickl system coupled
  6 KB (835 words) - 15:51, 9 November 2016
• Harper 2018 MiPschool Tromso E1
  ...on of brown adipose tissue (BAT) can cause a doubling of resting metabolic rate. This remarkable increase in whole body oxygen consumption and thermogenesi
  3 KB (502 words) - 12:14, 17 October 2018
• Cardoso 2022 Abstract Bioblast
  ...x push by electron input), coupling control exerts opposite effects on the metabolic parameters. Whereas redox push reduces the N- and Q-pool in the LEAK state
  3 KB (463 words) - 08:34, 28 July 2022
• Porter 2018 MiP2018b
  ...d massive burns, encompassing 54±20% of their body surface area. Metabolic rate was elevated by 44% and 47% at 2- and 4-weeks post-injury, respectively (P<
  3 KB (434 words) - 08:11, 13 September 2018
• Amoedo 2012 Abstract Bioblast
  ...ed by diluting the cells from the spheroids of the '''4C''' cell line. The metabolic profile of each of these different cell lines was investigated by evaluatin
  7 KB (983 words) - 11:16, 8 June 2020
• Bento 2017 MITOEAGLE Obergurgl
  ...ablish a protocol to isolate and expand USCs, enabling for a mitochondrial metabolic characterization. ...ng, different cell densities were used to determine the oxygen consumption rate (OCR) using the Seahorse XFe96 Extracellular Flux Analyzer. The optimized c
  3 KB (465 words) - 15:47, 12 January 2018
• Romagnolo 2024 Acta Neuropathol
  ...lack of responsiveness to various stimuli, compromised oxygen consumption rate and reserve respiratory capacity underscoring their reduced capacity to rea
  4 KB (476 words) - 17:26, 5 March 2024
• Zdrazilova Lucie
  ...ndicator of mitochondrial respiration, and (2) extracellular acidification rate (ECAR) measuring extracellular acidification largely depending on glycolyti :::: Congenital disorders of glycosylation (CDG) are rare inherited metabolic diseases caused by abnormal protein and lipid glycosylation. PMM2-CDG is th
  14 KB (1,959 words) - 17:43, 5 January 2023
• Munro 2013 Abstract MiP2013
  ...J, Pamplona R, Buffenstein R, Buttemer WA (2007) Life and death: Metabolic rate, membrane composition, and life span of animals. Physiol Rev 87: 1175–121
  3 KB (450 words) - 11:20, 28 April 2017
• Cardinale 2018 Thesis
  ...ch can be of significance in patients with heart, circulatory, and overall metabolic diseases. ...ndrial oxygen affinity varied with the degree of mitochondrial respiration rate and was lower in women compared to men. These results indicate that the hig
  6 KB (840 words) - 17:16, 7 March 2020
• Szibor 2020 J Biol Chem
  ...tes seemingly contradictory results and warrants a critical reappraisal of metabolic control mechanisms in health and disease.
  3 KB (459 words) - 10:11, 8 June 2020
• Burtscher 2012 Abstract Bioblast
  ...ases, the rapid development of fatigue which cannot simply be explained by metabolic aspects of working muscles affects exercise performance. Recent studies sug
  4 KB (492 words) - 17:14, 3 February 2016
• Matallo MiP2010
  ...acrophages paying particular attention at the influence of temperature and metabolic activity of the cells. ...and 22.2 [18.5; 26.5] µM at low injection rate (P<0.05). At high injection rate, 50% inhibition was achieved at 20.6 [17.8; 21.4] µM, i.e. at a statistica
  7 KB (955 words) - 15:31, 24 January 2018
• Op den Kamp 2022 Mol Metab
  ...ects on cardiovascular and renal outcomes; the underlying mechanism may be metabolic adaptations due to urinary glucose loss. Here, we investigated the cellular ..., intramyocellular lipid (IMCL) content and phosphocreatine (PCr) recovery rate were measured by magnetic resonance spectroscopy (MRS). ''Ex vivo'' mitocho
  3 KB (443 words) - 19:13, 15 March 2023
• Canevarolo 2017 Thesis
  cell lines. Proliferation tests, metabolic studies, drug synergism, quantification of cellular ...s within 48 h of treatment (but not 96 h) was related to the proliferation rate of the cells.
  4 KB (532 words) - 18:30, 31 January 2020
• Schulte 2013 Abstract MiP2013
  |abstract=Based on its presumed role in altering whole-animal metabolic rate, the mitochondrion has become the focus of hypotheses that address the proc
  3 KB (459 words) - 11:10, 28 April 2017
• Dias 2017 MiPschool Obergurgl
  Sertoli cells (SCs) play a key role in spermatogenesis support. Their high metabolic rates and mitochondrial activity are associated with a high production of r ...uated using the JC-1 probe. We also performed an O₂ consumption rate assay using the MitoXpress kit. Oxidative damage levels to proteins and lip
  5 KB (774 words) - 15:59, 12 January 2018
• Karavaeva Iuliia
  Novo Nordisk Foundation Center for Basic Metabolic Research, ...nding of BAT metabolism and potentially contribute to development of novel metabolic disease treatment strategies.
  12 KB (1,689 words) - 16:20, 16 March 2020
• Groennebaek 2018 Front Physiol
  ...nction. If so, BFRRE could provide a feasible strategy to stimulate muscle metabolic health. Mitochondrial protein synthesis rate was higher with BFRRE (1.19%/day) and HLRE (1.15%/day) compared to CON (0.9
  4 KB (476 words) - 12:39, 8 August 2019
• Raboel 2009 Diabetes Obes Metab
  ...fear of hypoglycaemia, the anabolic effect of insulin, decreased metabolic rate and increased efficiency in fuel usage. The purpose of the study was to tes
  4 KB (532 words) - 21:39, 9 February 2020
• Bouillaud 2013 Abstract MiP2013
  ...nge is the ratio between the flux of sulfide delivered and the respiratory rate before sulfide infusion (''J''H2S/''J''O2) indicating a relative sulfide ex ...electron transfer in Complex I to increase further their sulfide disposal rate [5]. However, when the sulfide exposure is too high the colonocytes switch
  6 KB (870 words) - 11:04, 28 April 2017
• Galina 2013 Abstract MiP2013
  ...onsuming path of glycolysis. Importantly, the mt-HK acts by modulating the rate of oxidative phosphorylation putting succinate dehydrogenase in a state of
  4 KB (493 words) - 14:15, 13 November 2017
• Fulton 2019 Abstract IOC139
  |abstract=Skeletal muscle can experience a 20-fold range of rate of metabolic heat production in athletes, subjecting mitochondria to levels of hyperther
  4 KB (545 words) - 12:36, 12 June 2019
• Nemec 2018 MiP2018
  Sedentary behavior increases the age-related risk of neurodegenerative and metabolic diseases. Therefore, we investigated effects of combined aerobic/strength t ...ruments, Austria) using SUIT RP1 and RP2 protocols [1]. Oxygen consumption rate was expressed in pmol per mg of tissue wet weight per second. Statistical a
  4 KB (476 words) - 00:16, 18 March 2019
• Oliveira 2015 Abstract IOC100
  ...le=Oliveira MT, Saari S, Andjelkovic A, Jacobs HT (2015) Investigating the metabolic alterations caused by the transgenic expression of the mitochondrial altern ...ndrial metabolism, AOX-expressing flies showed developmental problems (low rate of pupa eclosion) whose intensity appears to be related to the amount of ca
  4 KB (531 words) - 17:06, 27 March 2018
• The protonmotive force and respiratory control
  ...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. We plan a series of follow-up reports by the expanding Mi ::::* '''[[Resting metabolic rate]]'''
  12 KB (1,564 words) - 23:40, 25 January 2021
• Thomas 2017 Thesis
  ...transcriptional regulator of numerous anti-oxidant, anti-inflammatory, and metabolic genes. We observed that, paradoxically, Nrf2 protein levels decline in the ...ncreases in proton leak and complex II contributions to oxygen consumption rate (4.2 and 3.6-fold respectively, N=4, p<0.05), along with a significant decl
  7 KB (986 words) - 16:17, 13 November 2017
• Kawalec 2016 Praca doktorska
  ...ntation of the mitochondrial network, mitochondria aggregation, as well as metabolic changes. Mfn2 is also present on the endoplasmic reticulum (ER) surface, pa ...d. It was observed that both, Mfn2 and Mfn1/2 gene knockout in MEFs causes metabolic switch from oxidative phosphorylation to glycolysis. However, this phenomen
  7 KB (1,050 words) - 14:51, 13 November 2017
• Bioblast alert 2012
  ...apparent [[excess capacity]] of cytochrome c oxidase, '''[[basal metabolic rate]]''', [[P/O ratio]]s and ergometric [[efficiency]]: ...Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J 25: 2843-52.]]
  8 KB (1,102 words) - 12:32, 25 November 2020
• MiPNet23.14 IOC135 Busan KR
  :::: Cardiovascular and Metabolic Disease Center :::: Cardiovascular and Metabolic Disease Center (CMDC)
  8 KB (1,031 words) - 15:54, 5 December 2019
• Ling 2019 Am J Clin Nutr
  ...0.75)], with many differentially expressed genes associating with positive metabolic outcomes. Pathway analyses revealed an increase in fatty acid oxidation ( P
  4 KB (535 words) - 15:32, 15 October 2019
• Zhang 2015 Abstract MiPschool Greenville 2015
  ...the action of nicotinamide phosphoribosyltransferase (NAMPT), the putative rate-limiting enzyme in the NAD+ salvage pathway. We hypothesized that elevated
  4 KB (547 words) - 14:52, 23 January 2019
• Truu 2017 MiP2017
  ...and its importance for metabolic regulation. The flux was measured as the rate of oxygen consumption, using High-Resolution FluoRespiromety (Oroboros Inst
  4 KB (558 words) - 15:22, 17 October 2017
• Chakrabarti 2017 Abstract MITOEAGLE Barcelona
  ...the Pipistrelle bat. These are two mammals with similar size and metabolic rate but very different maximal lifespans, the bat being exceptionally long-live
  5 KB (654 words) - 14:32, 12 January 2018
• MitoCom lectures
  ...+%2526+e-Alerts&utm_campaign=e3c2ffc563-Daily_10212011&utm_medium=email '''Metabolic melodies'''] ...Lundberg JO (2011) Mitochondrial oxygen affinity predicts basal metabolic rate in humans. FASEB J. 25: 2843-2852]].
  7 KB (903 words) - 15:01, 8 June 2020
• Enriquez 2014 Mol Syndromol
  ...observed rate of electron transfer of the entire respiratory chain and the rate of either reduction or oxidation of CoQ [Kröger and Klingenberg, 1973], ha ...y metabolic flux analysis, this proposition requires that the dissociation rate constants (''k''_off) of bound CoQ be considerably slower than th
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• Bioblast quiz
  - Glycolysis rate measurement - Directly determining the rate of glycolysis
  36 KB (5,157 words) - 12:10, 12 April 2024
• ROUTINE respiration
  :::: '''Basal respiration''' or "basal metabolic rate" is frequently used as [[LEAK respiration]]. Importantly, we have to make a
  6 KB (875 words) - 10:38, 17 November 2021
• Forbes-Hernandez 2017 MiPschool Obergurgl
  ...e, mitochondrial modulation has been proposed as a prospective therapy for metabolic diseases. Scientific evidence indicates the role of strawberries in the red For that purpose the oxygen consumption rate (OCR) was examined using an XF24 Extracellular Flux Analyzer (Seahorse Bios
  6 KB (748 words) - 04:18, 12 February 2020
• MitoPediaAlert2020 Archive
  ...ally with the size of ''X''. Flux is a size-independent quantity where the rate is expressed per mass or volume of sample. <br> ...i10.26124bec2020-0001.v1 BEC2020.1: Mitochondrial physiology]'''« - Box 2. Metabolic flows and fluxes: vectoral, vectorial, and scalar <br>
  21 KB (2,889 words) - 13:31, 19 January 2021
• Froment 2022 Hum Reprod
  ...3). Female mice deficient in α1AMPK had a 30% decrease in their ovulation rate (P < 0.05, n = 7) and litter size, a hyperandrogenic response (P < 0.05, n ...marker of interest in infertility cases related to hormonal imbalances and metabolic disorders, including PCOS.
  6 KB (829 words) - 15:00, 30 November 2022
• Silkuniene 2017 MiPschool Obergurgl
  ...(Mt) or lack of oxygen in the cancer cells [1]. The shift in understanding metabolic changes in cancer cells occurred recently regarding the role and activity o ...H was evaluated spectrophotometrically at 340 nm, measuring NADH oxidation rate in isolated mitochondria or crude cell lysates (0.2 mg protein in reaction)
  6 KB (856 words) - 16:15, 12 January 2018
• MitoFit Open Seminars
  ::::* 16:00-17:00 [[Garcia-Roves_PM|Pablo Garcia-Roves, ES]]: "Metabolic plasticity in obesity-related type 2 diabetes" ...ations of high-resolution respirometry as useful tool to characterize rare metabolic disorders. - [[Media:ZdrazilovaL_abstract_MitoFit open seminar_13_06_2019.p
  33 KB (4,250 words) - 15:07, 2 February 2022
• Gnaiger 2018 MiPschool Tromso A1
  ::::::# Which metabolic problems occur when S is supplied alone to mitochondrial preparations, and ::::::# What is the difference between a respiratory state and a respiratory rate?
  10 KB (1,441 words) - 23:46, 25 January 2021
• Kaambre 2015 Abstract MiP2015
  Apparent Michaelis-Menten constant (Km) and maximal rate of respiration (Vm) for ADP were calculated to characterize the affinity of ...a M, Timohhina N, Tepp K, Bogovskaja J, Kütner R, Valvere V, Saks V (2012) Metabolic control analysis of cellular respiration in situ in intraoperational sample
  6 KB (817 words) - 14:53, 23 January 2019
• Steady state
  ...es, ADP, P_i, H⁺) do not exert significant effects on metabolic fluxes (respiration, phosphorylation). Such pseudo-steady states require re :::: Oxygen fluxes should stabilize — reaching a constant value of the rate — before proceeding with the next titration in the SUIT protocol. The fol
  8 KB (1,115 words) - 03:00, 23 January 2023
• Isola 2017 MiPschool Obergurgl
  ...addiction. LV mitochondria, paradoxically, had a better oxygen consumption rate than controls for state III after glutamate, but this datum wasn’t parall ...20 weeks from developing diabetes, rats have clearly developed a diabetic metabolic syndrome, but their heart mitochondrial impairment is less severe than it w
  7 KB (995 words) - 09:26, 19 January 2018
• MiPNet16.03 IOC65
  ...lation of free Ca2+ in buffered solutions and [[PH electrode|acidification rate (pH)]] can be discussed/demonstrated. Please indicate your topics of intere |Metabolic remodeling in cardiac hypertrophy and heart failure.
  11 KB (1,519 words) - 10:53, 31 March 2021
• Nehlin 2018 MiP2018
  ...age as the difference in aging markers between the groups at baseline, the rate of aging as the development in aging markers between baseline and the 1-yea ...Sancarlo D, Pellegrini F, Ferrucci L, Pilotto A (2013) Identification of a metabolic signature for multidimensional impairment and mortality risk in hospitalize
  7 KB (971 words) - 10:29, 16 October 2018
• MitoEAGLE Verona 2016
  ...PBMC for high-resolution respirometry and association to [[basal metabolic rate]]. ::::* Accomodation revised flat rate: 95 EUR (according to the e-vote by the Management Committee)
  20 KB (2,554 words) - 08:51, 29 July 2022
• Laner 2013 Mitochondr Physiol Network MiP2013
  ...er 2013 Abstract MiP2013|Dietary inorganic nitrate reduces basal metabolic rate in man]]||A1-09 Oral ..., London, CA||[[Staples 2013 Abstract MiP2013| Mechanisms of mitochondrial metabolic depression in hibernation]]||A2-03 Oral
  26 KB (3,454 words) - 12:10, 23 January 2019
• Gnaiger 2015 Abstract MiPschool Cape Town 2015 II
  ...l growth is fundamentally different from the definition of basal metabolic rate (BMR).
  13 KB (2,089 words) - 18:19, 7 November 2020
• O2k-pH ISE-Module
  ...units [pmol·s^-1·mL^-1]]. The physiologically relevant metabolic proton flux, therefore, must not be confused with ECAR. ...priate flow rate for the TIP. In the simplest implementation just one flow rate is used for about 5 minutes. From the first time derivative of the pH signa
  37 KB (5,713 words) - 12:13, 28 February 2023
• Pike 2011 Biochim Biophys Acta
  ...ransferase I (CPT1) with low concentrations of etomoxir, the proliferation rate of various cancer cells was unaffected. Efforts to pharmacologically inhibi ...Mutant p53-microRNA-200c-ZEB2-Axis-Induced CPT1C Elevation Contributes to Metabolic Reprogramming and Tumor Progression in Basal-Like Breast Cancers. Front Onc
  11 KB (1,581 words) - 12:38, 21 April 2023
• MitoEAGLE Task Group States and rates
  ...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states an ...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.”'''
  34 KB (4,911 words) - 11:25, 1 September 2021
• Picard 2011 PLoS One
  :::::: ''Comment'': A higher rate of LEAK respiration ('state II, GM') per OXPHOS capacity ('state 3') is cla ::::* .. direct stimulation of Complex IV yielded an 82 % higher respiration rate in isolated mitochondria (Figure 3B). {Unfortunately, Figure 3B does not sh
  52 KB (7,111 words) - 14:50, 13 January 2023
• MiPNet17.08 IOC68 Schroecken AT
  | Metabolic diseases, cancer, neuroscience ...ree Ca²⁺ in buffered solutions and [[PH electrode|acidification rate (pH)]] can be discussed/demonstrated. Please indicate your topics of intere
  15 KB (2,242 words) - 14:11, 21 July 2020
• Schoepf 2019 MitoFit Preprint Arch
  ...mplex I, supporting a causal relationship. RNA-seq revealed a signature of metabolic enzymes corresponding to the altered mitochondrial respiratory pathways and ...oxidative phosphorylation, mitochondrial DNA mutation, mtDNA heteroplasmy, metabolic reprograming
  23 KB (3,225 words) - 08:30, 8 January 2023
• Gnaiger Erich
  ...erobic energy budgets and thermodynamic optimization in metabolic economy: Rate and power, versus efficiency. University of Innsbruck, Department of Zoolog ...PW, Schön A, Gnaiger E (1993) Microcalorimetric measurement of reversible metabolic suppression induced by anoxia in isolated hepatocytes. Am J Physiol 265:R10
  23 KB (2,953 words) - 07:51, 11 May 2024
• Oroboros Ecosystem Agenda 2024 Archive
  ...change in respiration after a single step, in which there is a change in a metabolic control variable.<br> - »'''[[Flux control efficiency]]'''«, »'''[[Metabolic control variable]]'''«<br>
  29 KB (4,269 words) - 09:03, 13 May 2024
• Gnaiger 2020 BEC MitoPathways
  ...standing of mitochondrial respiratory control relies on a clear concept of metabolic states and rates, accurate measurement and normalization of oxygen flux, an ...ic control variables on flow or flux can be expressed by normalization for rate in a ''reference state'', and is evaluated relative to a ''background state
  89 KB (12,074 words) - 17:54, 6 May 2024
• Gnaiger 2012 MitoPathways
  ...| Nicholson JK, Holmes E, Kinross JM, Darzi AW, Takats Z, Lindon JC (2012) Metabolic phenotyping in clinical and surgical environments. Nature 491:384-92.]] ...robbio S, Rubi B (2006) In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol 38: 696-709.
  34 KB (4,820 words) - 04:08, 23 November 2021
• K-Regio MitoFit
  ...printing'''. Diagnostic analyses include cardiopulmonary (VO2max; CPX) and metabolic (31P-NMR; Ergospect) exercise testing, evaluation of mitochondrial performa ...oupling of external to cellular respiration, it mirrors insufficiently the metabolic processes in the contracting and recovering muscle. Thus, combining CPX and
  43 KB (5,966 words) - 07:05, 29 March 2024
• Gnaiger 2012 MitoPathways References
  ...HA (1963) Substrate competition in the respiration of animal tissues. The metabolic interactions of pyruvate and α-oxoglutarate in rat-liver homogenates. Bioc ...robbio S, Rubi B (2006) In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol 38:696-709.
  25 KB (3,492 words) - 06:44, 13 January 2021
• MitoEAGLE Barcelona 2017
  :::::* Obergurgl MitoEAGLE Training School (MiPschool) and WG Meeting – flat rate for accommodation will be the price for the double room: 66.- €. ::::* Obergurgl MitoEAGLE Training School (MiPschool) and WG Meeting – flat rate for accommodation will be the price for the double room: 66.- €.
  35 KB (4,778 words) - 08:51, 29 July 2022
• Gnaiger 2019 MitoFit Preprints
  ...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states an ...The mitochondrial acylome emerges: proteomics, regulation by Sirtuins, and metabolic and disease implications. Cell Metab 27:497-512. - [[Carrico 2018 Cell Meta
  38 KB (5,252 words) - 08:27, 8 January 2023
• Gnaiger 2014 MitoPathways
  :::# Nicholson JK, Holmes E, Kinross JM, Darzi AW, Takats Z, Lindon JC (2012) Metabolic phenotyping in clinical and surgical environments. Nature 491:384-92. - [[N ...robbio S, Rubi B (2006) In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol 38:696-709.
  51 KB (7,005 words) - 04:36, 19 July 2022
• Oroboros Ecosystem Agenda 2023 Archive
  ...ur-Farraj P, Stassart RM, Fledrich R (2023) Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration. [[Sundaram_2023_Cell_Metab|»B |'''"Liver [mitochondria] (...) adapt to metabolic challenges by increasing FAO-derived mitochondrial respiration in OBES [obe
  80 KB (11,165 words) - 09:37, 8 January 2024
• Oroboros Ecosystem Agenda 2022 Archive
  ...metabolic features of BSF and provide a hypothesis to explain the unusual metabolic network and its biological significance for this parasite form. <br> ...ssue] shows a persistent mitochondrial dysfunction that compromises tissue metabolic plasticity after obesity"''' <br>
  87 KB (11,941 words) - 15:14, 16 November 2023
• BEC 2020.1 doi10.26124bec2020-0001.v1
  ...ical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states an ...[[MitoPedia: Respiratory states |Respiratory states]] • [[Normalization of rate]] • [[Oxidative phosphorylation]] • [[Oxygen]] • [[Efficiency |Phosph
  59 KB (8,156 words) - 13:41, 1 May 2024
• X-mass Carol
  ..., [[Mass]], [[Measure]], [[MitoPedia]], [[Molar mass]], [[Normalization of rate]], [[Object]], [[Organism]], [[Permeabilized cells]], [[Publish]], [[Sample ...creased blood glucose, elevated blood lipids and obesity. These are called metabolic risk factors that can lead to cardiovascular disease, the leading NCD in te
  171 KB (27,973 words) - 19:50, 27 December 2021
• Oroboros Ecosystem Agenda 2020 Archive
  The project aims to connect specific/broad kinase activities to precise metabolic functions (mitochondria) relevant for cell proliferation or survival. Orobo ...ally with the size of ''X''. Flux is a size-independent quantity where the rate is expressed per mass or volume of sample. <br>
  126 KB (17,785 words) - 08:55, 13 August 2021
• Oroboros Ecosystem Agenda 2021 Archive
  ...diet activates liver iPLA₂γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62: 100052. [Epub ahead of print]. [[Moon 2021 J Lipid ...re T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS
  85 KB (11,819 words) - 14:18, 10 January 2022
• COST Action MitoEAGLE
  ...tandardized measures to link mitochondrial and physiome performance (heart rate, BMI, blood pressure, blood chemistry, ''V''_O2max) to understand ...jury in the context of several in vitro and in vivo experimental models of metabolic syndrome.
  56 KB (7,818 words) - 11:01, 7 April 2021