Bioblast alert - 2020
Bioblast alert 2020(18) - Bioenerg Commun & MitoFit Preprints: 2020-12-07
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Adressing the importance for biotechnological exploitations
Methodology enabling expansion of current knowledge in the field of chloroplast and algal bioenergetics:
- Huete-Ortega M, Di Marcello M, Iglesias-Gonzalez J, Gnaiger E (2020) High-resolution respirometry for chloroplast and mitochondrial bioenergetics in Chlamydomonas reinhardtii ā towards biotechnology exploitations. MitoFit Preprint Arch doi:10.26124/mitofit:ea20.algaeurope.0001. - Ā»Bioblast linkĀ«
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Submit your preprint to MitoFit Preprints and increase awareness of your research::
Journal articles that were uploaded as preprints before being published gather more citations in the long run than papers without a preprint version. The effect is immediate and long-lasting.
Ā» How to submit your preprintĀ«
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To publish scientific and technical advances in bioenergetics and mitochondrial physiology in living communications, submit your paper to the Open Access journal Bioenergetics Communications.
Ā» Bioenergetics Communications Ā«
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Bioblast alert 2020(17) - H2O2 flux: 2020-11-30
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Background H2O2 calibration in the AmplexĀ® UltraRed (AmR) assay:
A background H2O2 calibration is performed before addition of sample. This is required for (1) calculation of the chemical background fluorescence in our Excel analysis template, and (2) calculation AmR assay sensitivity, for quality control.
- Ā»Background H2O2 calibrationĀ«
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Why do we perform multiple H2O2 calibrations in the AmplexĀ® UltraRed assay?
The sensitivity to H2O2 of the fluorometric signal changes during the experiment as a function of: (1) experimental time and accumulating UltroxRed (similar to resorufin), (2) changes of the optical properties due to titrations, and (3) the radical scavenging capacity of the sample. Therefore, H2O2 calibrations are performed before and after sample addition, and after selected titration steps.
- Ā»Amplex UltraRedĀ« and Ā»Komlodi 2018 Methods Mol BiolĀ«
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Are permeabilized muscle fibers (pfi) a reliable model for studying ROS production?
High oxygen concentrations are needed to avoid oxygen limitation in pfi. However, high oxygen pressures may artificially increase ROS prodcution, including H2O2, making pfi a questionable model for ROS production.
- Ā»Oxygen dependence of ROS production in pfiĀ«
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Bioblast alert 2020(16) - PBMC and Platelets: 2020-10-23
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Childhood maltreatment is associated with increased mitochondrial bioenergetic function of immune cells in mothers, but not in their newborns
- from the O2k-Network Ā»DE Ulm Gumpp AĀ«
- Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-FernĆ”ndez L, Welz T, GĆ¼ndel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84. Ā»Bioblast linkĀ«
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Bioblast alert 2020(15) - Upcoming Virtual Events: 2020-09-17
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Free registration: European Society for Clinical Investigation Virtual Meeting 2020 ā COVID19 edition - Sep 20-30, 2020
- Ā»ESCI 2020 Virtual EventĀ«
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Bioblast alert 2020(14) - The potential of PBMCs in HRR: 2020-09-08
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Mitochondrial respiration in PBMCs from patients with major depression
- from the O2k-Network Ā»DE Ulm Karabatsiakis AĀ« and Ā»DE Ulm Radermacher PĀ«
- Karabatsiakis A, Boeck C, Salinas-Manrique J, Kolassa S, Calzia E, Dietrich DE, Kolassa IT (2014) Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression. Transl Psychiatry 4:e397. Ā»Bioblast linkĀ«
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Mitochondrial respiration in PBMCs: a potential parameter to monitor acute pancreatitis
- from the O2k-Network Ā»NZ Auckland Hickey AJĀ«
- Chakraborty M, Hickey AJ, Petrov MS, Macdonald JR, Thompson N, Newby L, Sim D, Windsor JA, Phillips AR (2016) Mitochondrial dysfunction in peripheral blood mononuclear cells in early experimental and clinical acute pancreatitis. Pancreatology 16:739-47. Ā»Bioblast linkĀ«
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Low-intensity exercise increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults
- from the O2k-Network Ā»LV Riga Makrecka-Kuka MĀ«
- Liepinsh E, Makarova E, Plakane L, Konrade I, Liepins K, Videja M, Sevostjanovs E, Grinberga S, Makrecka-Kuka M, Dambrova M (2020) Low-intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults. Physiol Rep 8:e14489. Ā»Bioblast linkĀ«
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Bioblast alert 2020(13) - MitoFit Preprints & BEC news: 2020-08-12
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Some terms in āMitochondrial physiologyā Bioenergetics Communications 2020.1 (States and rates) did not look familiar ā what is the elementary unit [x]?
Fundamental answers, a critical discussion on the SI unit for count, and the meaning of Euclidās unit and Euclidās number are presented in an unusual ācanonical reviewā:
- Gnaiger Erich (2020) Canonical reviewer's comments on: Bureau International des Poids et Mesures (2019) The International System of Units (SI) 9th ed. MitoFit Preprint Arch 2020.4 doi:10.26124/mitofit:200004. - Ā»Bioblast linkĀ«
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Join the discussion on the MitoEAGLE Consortium Communication: āMitochondrial physiologyā Bioenergetics Communications 2020.1
Ā» On a Comment in Nature Metabolism Ā«
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Bioblast alert 2020(12) - O2k-Publications: 2020-07-17
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Alternative oxidase inhibition plays a key role in the aluminum tolerance of cultured Jatropha curcas cells
- from the O2k-Network Ā»BR Ribeirao Preto Alberici LCĀ«
- Vicentini TM, Cavalheiro AH, Dechandt CRP, Alberici LC, Vargas-Rechia CG (2019) Aluminum directly inhibits alternative oxidase pathway and changes metabolic and redox parameters on Jatropha curcas cell culture. Plant Physiol Biochem 136:92-97. Ā»Bioblast linkĀ«
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Mitochondrial H2O2 flux in cardiac and skeletal muscle preparations is influenced by experimental oxygen concentration
- from the O2k-Network Ā»US CO Fort Collins Chicco AJĀ«
- Li Puma LC, Hedges M, Heckman JM, Mathias AB, Engstrom MR, Brown AB, Chicco AJ (2020) Experimental oxygen concentration influences rates of mitochondrial hydrogen peroxide release from cardiac and skeletal muscle preparations. Am J Physiol Regul Integr Comp Physiol 318:R972-80. Ā»Bioblast linkĀ«
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Influenza A infection induces persistent alterations in whole-body glucose metabolism in mice
- from the O2k-Network Ā»FR Lille Duez HĀ«
- Ayari A, Rosa-Calatrava M, Lancel S, Barthelemy J, Pizzorno A, Mayeuf-Louchart A, Baron M, Hot D, Deruyter L, Soulard D, Julien T, Faveeuw C, Molendi-Coste O, Dombrowicz D, Sedano L, Sencio V, Le Goffic R, Trottein F, Wolowczuk I (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237. Ā»Bioblast linkĀ«
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The antidiabetic drug empagliflozin protects cardiac mitochondria against high-fat diet-induced dysfunction in mice
- from the O2k-Network Ā»LV Riga Makrecka-Kuka MĀ«
- Makrecka-Kuka M, Korzh S, Videja M, Vilks K, Cirule H, Kuka J, Dambrova M, Liepinsh E (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther [Epub ahead of print]. Ā»Bioblast linkĀ«
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Bioblast alert 2020(11) - O2k-Publications: 2020-05-20
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F1FO-ATP synthase regulates alternative oxidase in Trypanosoma brucei
- from the O2k-Network Ā»BR Sao Paulo Silber AMĀ«
- LuĆ©vano-MartĆnez LA, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print]. Ā»Bioblast linkĀ«
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Restoration of mitochondrial oxygen consumption and decrease of mitochondrial ROS by AOX in the post-ischaemic heart are not sufficient to confer acute or chronic cardioprotection in mice
- from the O2k-Network Ā» FI Helsinki Jacobs HTĀ« , Ā»DE Magdeburg Gellerich FNĀ« , Ā»FI Tampere Dufour EĀ« , Ā»DE Magdeburg Debska-Vielhaber GĀ« and Ā»DE Frankfurt Wittig IĀ«
- Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich Frank N, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.. - Ā»Bioblast linkĀ«
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Physical activity has positive effects on mitochondria from patients with occupational burnout
- from the O2k-Network Ā»CH Basel Eckert AĀ«
- Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout - an interventional pilot study. J Clin Med 9:E667. - Ā»Bioblast linkĀ«
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Allergic rhinitis induces mitochondrial dysfunction in peripheral blood cellsĀ«
- from the O2k-Network Ā»FR Strasbourg Zoll JĀ«
- Qi S, Barnig C, Charles AL, Poirot A, Meyer A, Clere-Jehl R, de Blay F and Geny Bernard
(2017) Nasal allergen challenge in allergic rhinitis induces mitochondrial dysfunction of peripheral blood mononuclear cells. Ann Allergy Asthma Immunol 118:367-9. Ā»Bioblast linkĀ«
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Bioblast alert 2020(10) - MitoEAGLE & BEC news: 2020-05-20
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SI units
One year ago, on World Metrology Day (2019-May-20) the redefinition of the SI units came into force. Science faced one of the largest overhauls in history of scientific units. How to commemorate this event of groundbreaking innovation better than with the online publication of Mitochondrial physiology and with the launch of an innovative journal ā Bioenergetics Communications.
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Bioblast alert 2020(09) - MitoEAGLE News: 2020-04-09
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The MitoEAGLE whitepaper on āMitochondrial respiratory states and ratesā is now ready for re-submission to Nature Metabolism. The full-length preprint with a total word count of 17,000 has been reduced to 3,000 words text plus figures and references, including all original sections.
Version 6 of the paper with all 620 coauthors is available here:
Ā» www.mitoeagle.org/index.php/Gnaiger_2019_MitoFit_Preprint_Arch
Please contact us, if you are interested to see the shortened version of the manuscript.
If you intend to join as an additional coauthor, please send your comments, full institutional address and preferentially your ORCID iD to [email protected]
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Bioblast alert 2020(08) - MitoFit Preprints News: 2020-03-25
Bioblast alert 2020(07): 2020-03-20
From MitoFit Preprints to Nature Communications
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High-resolution respirometry in human prostate cancer biopsies and mtDNA analyzed in samples recovered from the O2k-chamber
- from the O2k-Network Ā»AT Innsbruck OroborosĀ«
Schƶpf Bernd, Weissensteiner Hansi, SchƤfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, SantāAnna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 2020-03-20 [Epub ahead of print]. - Ā»Bioblast linkĀ«
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Do you know what a preprint is? With a preprint you can communicate recent findings to the scientific community, receiving input from other scientists before submitting to a peer-reviewed journal. - Ā»PreprintĀ«
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Bioblast alert 2020(06): 2020-02-26
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An active lifestyle protects cardiac mitochondria
- from the O2k-Network: Ā»KR Busan Han JĀ«, Ā»KR Incheon Kwak HBĀ«
- No MH, Heo JW, Yoo SZ, Kim CJ, Park DH, Kang JH, Seo DY, Han J, Kwak HB (2020) Effects of aging and exercise training on mitochondrial function and apoptosis in the rat heart. Pflugers Arch 472:179-93. - Ā»Bioblast linkĀ«
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Bioblast alert 2020(05): 2020-02-20
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Registration now open! 21st European Bioenergetics Conference. Marseille, France. 2020 Aug 22-27.
- Ā»EBEC2020Ā«
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Aging and hyperlipidemia impair aortic mitochondrial function and increase the risk of atherosclerosis
- from the O2k-Network US MI Ann Arbor Beard DA
Tyrrell DJ, Blin M, Song J, Wood S, Zhang M, Beard DA, Goldstein D (2019) Age-associated mitochondrial dysfunction accelerates atherogenesis. Circ Res 126:298ā314. Ā»Bioblast linkĀ«
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Spermidine and other calorie restriction mimetics control autophagy and mitochondrial function.
- Ā»SpermidineĀ«
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MitoFit Preprints was initiated one year ago on February 19, 2020.
- We invite submissions of mitochondrial preprints.
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Bioblast alert 2020(04): 2020-02-07
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Save the date! April 24-25, 2020 - The first meeting of the Bioenergetics DE-CH-AT Group aims at exchange and collaboration in bioenergetics between Germany, Switzerland and Austria.
- Ā»Bioenergetics Vienna 2020Ā«
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Blood cell mitochondrial function does not provide a general substitute for muscle biopsies
- from the O2k-Network: US AR Little Rock Boersheim E
Rose S, Carvalho E, Diaz EC, Cotter M, Bennuri SC, Azhar G, Frye RE, Adams SH, Boersheim E (2019) A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. Am J Physiol Endocrinol Metab 317:E503-E512. - Ā»Bioblast linkĀ«
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Cronin (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.- Ā»SpermidineĀ«
Nature - Lymphocytes, Cancer - O2k-brief repository
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Aerobic and resistance training address central defects and peripheral comorbidities in Alzheimerās disease
- from the O2k-Network: US FL Boca Raton Khamoui AV
Pena GS, Paez HG, Johnson TK, Halle JL, Carzoli JP, Visavadiya NP, Zourdos MC, Whitehurst MA, Khamoui AV (2020) Hippocampal growth factor and myokine cathepsin B expression following aerobic and resistance training in 3xTg-AD mice. Int J Chronic Diseases 2020:Article ID 5919501. - Ā»Bioblast linkĀ«
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Bioblast alert 2020(03): 2020-01-31
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The European Society for Surgical Research Congress early bird registration deadline is Monday February 10, 2020.
- Ā»ESSR 2020 Innsbruck ATĀ«
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Mitochondrial respiration is oxygen-dependent in human cardiac homogenate preparations
- from the O2k-Network: CZ Prague Krajcova A
KrajÄovĆ” A, Urban T, Megvinet D, Waldauf P, BalĆk M, HlaviÄka J, Budera P, JanouÅ”ek L, PokornĆ” E, DuÅ”ka F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142. - Ā»Bioblast linkĀ«
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Mitochondrial respiration of blood cells and cardiovascular disease
- from the O2k-Network: FR Strasbourg Zoll J
Alfatni A, Riou M, Charles AL, Meyer A, Barnig C, Andres E, Lejay A, Talha S, Geny B (2020) Peripheral blood mononuclear cells and platelets mitochondrial dysfunction, oxidative stress, and circulating mtDNA in cardiovascular diseases. J Clin Med 9 pii:E311. - Ā»Bioblast linkĀ«
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Reproducibility committment in high-resolution respirometry: quality control in oxygen calibration
In the DatLab 7.4 software, new instrumental DL-Protocols guide the user automatically step-by-step, to calibrate the instrument accurately. Reproducibility is monitored and documented when following user-friendly standard operating procedures (SOP). - Ā»Oxygen calibration - DatLabĀ«
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Bioblast alert 2020(02): 2020-01-24
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The Association for Psychological Science 2020 conference abstract submission deadline for poster presentations is Friday January 31, 2020.
- Ā» Bioblast linkĀ«
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Dias et al (2018) Analysis of respiratory capacity in brain tissue preparations: high-resolution respirometry for intact hippocampal slices. Anal Biochem
- Nervous system Ā»Bioblast linkĀ«
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HRR - high-resolution respirometry and oxygen kinetics 10 years ago: Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 2010.
- Ā»Bioblast linkĀ«
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Two websites:
- One new: the Oroboros MarketPlace website Ā»www.oroboros.atĀ«
- One continued: the website of the Oroboros Ecosystem Ā»www.bioblast.atĀ«
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Bioblast alert 2020(01): 2020-01-17
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In focus
Summary
Bioblast alert - previous issues
Stay alert
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