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P-L control efficiency

From Bioblast


high-resolution terminology - matching measurements at high-resolution


P-L control efficiency

Description

P-L control efficiency The P-L control efficiency (P-L flux control efficiency) is defined as jP-L = (P-L)/P = 1-L/P. OXPHOS capacity corrected for LEAK respiration is the P-L net OXPHOS capacity, P-L. The P-L control efficiency is the ratio of net to total OXPHOS capacity, which is equal to the biochemical E-L coupling efficiency, if P=E. jP-L = 1.0 for a fully coupled system (when RCR approaches infinity); jP-L = 0.0 (RCR=1) for a system with zero respiratory phosphorylation capacity (P-L=0) or zero E-L coupling efficiency (E-L=0 when L=P=E). If State 3 is measured at saturating concentrations of ADP and Pi (State 3 = P), then the respiratory acceptor control ratio RCR equals P/L. Under these conditions, the respiratory control ratio and P-L control efficiency are related by a hyperbolic function, jP-L = 1-RCR-1. » MiPNet article

Abbreviation: jP-L

Reference: Gnaiger 2015 Scand J Med Sci Sports, Gnaiger 2020 BEC MitoPathways

Cell ergometry: OXPHOS-control and ET-coupling efficiency

Publications in the MiPMap
Gnaiger E (2020) Cell ergometry: OXPHOS-control and ET-coupling efficiency. Mitochondr Physiol Network (2015-01-18) last update 2020-11-12.


Oroboros (2020) MiPNet

Abstract: The respiratory acceptor control ratio RCR has conceptual limitations that lead to statistical bias, which are resolved by expressing biochemical coupling efficiency in terms of E-L coupling efficiency. The arithmetic mean calculated for RCR values yields a bias of overestimation due to nonsymmetrical variance (Fig. 2). The concept of coupling efficiency is explained in the context of cell ergometry.


O2k-Network Lab: AT Innsbruck Gnaiger E

From spiroergometry to OXPHOS control efficiency

Analogous to ergometric measurement of VO2max or VO2peak on a cycle or treadmill (spiroergometry), cell ergometry is based on OXPHOS analysis to determine OXPHOS capacity, JO2P=P [pmol O2·s-1·mg-1], at the cellular and mitochondrial level. VO2peak and JO2P provide reference values for a subject’s or a cell’s aerobic or mitochondrial fitness. Aerobic catabolic flux (1 mL O2·min-1·kg-1 = 0.744 µmol·s-1·kg-1) is multiplied by the corresponding Gibbs forcekFO2 = ∂G/∂kξO2; typically -470 kJ/mol or -0.47 J/µmol O2) to obtain the mass-specific aerobic input power [W·kg-1]. The corresponding mechanical output power Ppeak [W·kg-1] in cycle ergometry results in ergodynamic efficiencies [1] of about 0.25,
εpeak  =  Ppeak/-(JO2peak·ΔkFO2)  =  (Ppeak/JO2peak) / -ΔkFO2                 (1)

The apparent E-P excess capacity is available for coupled processes other than phosphorylation P».
In OXPHOS analysis the output power is mitochondrial ATP production, J=P, times the Gibbs force of phosphorylation (ΔpG = ∂G/∂pξ), which is typically 48 to 62 kJ/mol P» [1]. Ergodynamic efficiency is a power ratio, partitioned into a flux ratio (the famous P»/O2 ratio; ATP yield per oxygen consumed, YP»/O2 = J/JO2P = (P-L)/P) and force ratio,
 εP  =  (J·ΔpF)/-(JO2P·ΔkFO2)  =  P»/P ∙ ΔpG/-ΔkFO2  =  jP-LfP-L         (2)
The upper limit of (P-L)/P is the mechanistic P»:O2 ratio or stoichiometric number, νP»/O2. The P-L net OXPHOS capacity is potentially available to drive phosphorylation P» (Figure 1). Quantitatively justified in cases [3] but better adjusted to the protonmotive force pmF, the dissipative LEAK component L in the OXPHOS state can be assessed by respiration L measured in the LEAK state,
νP»/O2 = P-Llimit/P = ~P/(P-L)                              (3)

Respiratory acceptor control ratio as a function of OXPHOS P-L control efficiency jP-L. RCR is the State 3/State 4 flux ratio [4], equal to P/L if State 3 is at saturating [ADP] and [Pi]. RCR from 1.0 to infinity is highly non-linear in the typical experimental range of RCR 3 to 10: when jP-L increases from 0.8 to 0.9, RCR doubles from 5 to 10. RCR increases to infinity at the limit of jP-L=1.0. Statistical analyses of RCR±SD require linearization by transformation to jP-L.


P»/P divided by /(P-L) defines the P-L control efficiency jP-L as a normalized flux ratio, which is a hyperbolic function of RCR (Figure 2) [5],
jP-L = (P-L)/P = 1-L/P = 1-RCR-1                            (4)
The P-L control efficiency in Equation (4) is determined by respirometric OXPHOS analysis. At the limit of maximum jP-L=1.0 the dissipative LEAK processes L are zero. Ergodynamic efficiency ε not only depends on mechanistic coupling but also on the force ratio or force efficiency. At ergodynamic equilibrium, ε=1.0, fluxes vanish to zero when jP-L = fP-L = 1 (Equation 2).
The OXPHOS state can be established experimentally in cells or tissues by selective permeabilization of plasma membranes, with ADP and Pi at kinetic saturation and CHNO fuel substrate combinations which reconstitute physiological TCA cycle function (Figure 1). The P-L net OXPHOS capacity may be kinetically limited by the phosphorylation system to utilize the pmF. Then ET capacity is in excess of OXPHOS capacity by the E-P control efficiency jE-P=(E-P)/E. Such kinetic limitation diminishes the effective jP-L independent of coupling control. Therefore, the E-L coupling efficiency is defined as jE-L=(E-L)/E (compare Eq. 4) and related to jP-L by taking into account the apparent E-P excess capacity (Figure 1),
jE-L = jP-L∙(1-jE-P) + jE-P                                         (5)

Flux control efficiencies are derived from principles of thermodynamics rather than being arbitrarily introduced as jargon of a specialized discipline.


References

  1. Gnaiger E (1993) Efficiency and power strategies under hypoxia. Is low efficiency at high glycolytic ATP production a paradox? In: Surviving hypoxia: mechanisms of control and adaptation. Hochachka PW, Lutz PL, Sick T, Rosenthal M, Van den Thillart G (eds) CRC Press: 77-109. - »Bioblast link«
  2. Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
  3. Gnaiger E (2001) Bioenergetics at low oxygen: dependence of respiration and phosphorylation on oxygen and adenosine diphosphate supply. Respir Physiol 128: 277-97. - »Bioblast link«
  4. Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217: 409-27. - »Bioblast link«
  5. Gnaiger 2014 Abstract MiP2014.


Keywords

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1. Mitochondrial and cellular respiratory rates in coupling-control states

OXPHOS-coupled energy cycles. Source: The Blue Book
» Baseline state
Respiratory rate Defining relations Icon
OXPHOS capacity P = -Rox P.jpg mt-preparations
ROUTINE respiration R = -Rox R.jpg living cells
ET capacity E = -Rox E.jpg » Level flow
» Noncoupled respiration - Uncoupler
LEAK respiration L = -Rox L.jpg » Static head
» LEAK state with ATP
» LEAK state with oligomycin
» LEAK state without adenylates
Residual oxygen consumption Rox L = -Rox ROX.jpg
  • Chance and Williams nomenclature: respiratory states
» State 1 —» State 2 —» State 3 —» State 4 —» State 5

2. Flux control ratios related to coupling in mt-preparations and living cells

» Flux control ratio
» Coupling-control ratio
» Coupling-control protocol
FCR Definition Icon
L/P coupling-control ratio L/P L/P coupling-control ratio » Respiratory acceptor control ratio, RCR = P/L
L/R coupling-control ratio L/R L/R coupling-control ratio
L/E coupling-control ratio L/E L/E coupling-control ratio » Uncoupling-control ratio, UCR = E/L (ambiguous)
P/E control ratio P/E P/E control ratio
R/E control ratio R/E R/E control ratio » Uncoupling-control ratio, UCR = E/L
net P/E control ratio (P-L)/E net P/E control ratio
net R/E control ratio (R-L)/E net R/E control ratio

3. Net, excess, and reserve capacities of respiration

Respiratory net rate Definition Icon
P-L net OXPHOS capacity P-L P-L net OXPHOS capacity
R-L net ROUTINE capacity R-L R-L net ROUTINE capacity
E-L net ET capacity E-L E-L net ET capacity
E-P excess capacity E-P E-P excess capacity
E-R reserve capacity E-R E-R reserve capacity

4. Flux control efficiencies related to coupling-control ratios

» Flux control efficiency jZ-Y
» Background state
» Reference state
» Metabolic control variable
Coupling-control efficiency Definition Icon Canonical term
P-L control efficiency jP-L = (P-L)/P = 1-L/P P-L control efficiency P-L OXPHOS-flux control efficiency
R-L control efficiency jR-L = (R-L)/R = 1-L/R R-L control efficiency R-L ROUTINE-flux control efficiency
E-L coupling efficiency jE-L = (E-L)/E = 1-L/E E-L coupling efficiency E-L ET-coupling efficiency » Biochemical coupling efficiency
E-P control efficiency jE-P = (E-P)/E = 1-P/E E-P control efficiency E-P ET-excess flux control efficiency
E-R control efficiency jE-R = (E-R)/E = 1-R/E E-R control efficiency E-R ET-reserve flux control efficiency

5. General

» Basal respiration
» Cell ergometry
» Dyscoupled respiration
» Dyscoupling
» Electron leak
» Electron-transfer-pathway state
» Hyphenation
» Oxidative phosphorylation
» Oxygen flow
» Oxygen flux
» Permeabilized cells
» Phosphorylation system
» Proton leak
» Proton slip
» Respiratory state
» Uncoupling


List of publications

Publications in the MiPMap
Click to expand or collaps
» OXPHOS and LEAK
 YearReferenceMammal and modelTissue and cellStressDiseases
Lee 2024 ACS Nano2024Lee CH, Wallace DC, Burke PJ (2024) Super-resolution imaging of voltages in the interior of individual, vital mitochondria. ACS Nano 18:1345−56. https://doi.org/10.1021/acsnano.3c02768
Cefis 2024 Acta Physiol (Oxf)2024Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G (2024) MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H2O2 emission. Acta Physiol (Oxf) [Epub ahead of print]. https://doi.org/10.1111/apha.14119MouseSkeletal muscleAging;senescence
Opperdoes 2024 BMC Genomics2024Opperdoes FR, Záhonová K, Škodová-Sveráková I, Bučková B, Chmelová Ľ, Lukeš J, Yurchenko V (2024) In silico prediction of the metabolism of Blastocrithidia nonstop, a trypanosomatid with non-canonical genetic code. BMC Genomics 25:184. https://doi.org/10.1186/s12864-024-10094-8Protists
Patil 2024 J Exp Biol2024Patil YN, Gnaiger E, Landry AP, Leno ZJ, Hand SC (2024) OXPHOS capacity is diminished and the phosphorylation system inhibited during diapause in an extremophile, embryos of Artemia franciscana. J Exp Biol 227:jeb.245828. https://doi.org/10.1242/jeb.245828ArtemiaHypoxia
Tsouka 2024 Commun Med (Lond)2024Tsouka S, Kumar P, Seubnooch P, Freiburghaus K, St-Pierre M, Dufour JF, Masoodi M (2024) Transcriptomics-driven metabolic pathway analysis reveals similar alterations in lipid metabolism in mouse MASH model and human. Commun Med (Lond) 4:39. https://doi.org/10.1038/s43856-024-00465-3MouseLiverOther
Hu 2024 Front Endocrinol (Lausanne)2024Hu Y, Fang B, Tian X, Wang H, Tian X, Yu F, Li T, Yang Z, Shi R (2024) Passive exercise is an effective alternative to HRT for restoring OVX induced mitochondrial dysfunction in skeletal muscle. Front Endocrinol (Lausanne) 15:1356312. https://doi.org/10.3389/fendo.2024.1356312MouseSkeletal muscle
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis2024Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033MouseNervous system
Liver
Oxidative stress;RONS
Dong 2024 Nat Commun2024Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H (2024) Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease. https://doi.org/10.1038/s41467-023-44057-6MouseLiver
Xiao 2024 Sci Adv2024Xiao L, Yin Y, Sun Z, Liu J, Jia Y, Yang L, Mao Y, Peng S, Xie Z, Fang L, Li J, Xie X, Gan Z (2024) AMPK phosphorylation of FNIP1 (S220) controls mitochondrial function and muscle fuel utilization during exercise. Sci Adv 10:eadj2752. https://doi.org/10.1126/sciadv.adj2752MouseSkeletal muscle
Qiao 2024 J Sport Health Sci2024Qiao YS, Blackwell TL, Cawthon PM, Coen PM, Cummings SR, Distefano G, Farsijani S, Forman DE, Goodpaster BH, Kritchevsky SB, Mau T, Toledo FGS, Newman AB, Glynn NW (2024) Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics: The Study of Muscle, Mobility and Aging (SOMMA). https://doi.org/10.1016/j.jshs.2024.02.001HumanSkeletal muscleAging;senescence
Visker 2024 Exp Physiol2024Visker JR, Leszczynski EC, Wellette-Hunsucker AG, McPeek AC, Quinn MA, Kim SH, Bazil JN, Ferguson DP (2024) Postnatal growth restriction alters myocardial mitochondrial energetics in mice. https://doi.org/10.1113/ep091304MouseHeart
Meszaros 2024 Transpl Int2024Meszaros AT, Weissenbacher A, Schartner M, Egelseer-Bruendl T, Hermann M, Unterweger J, Mittelberger C, Reyer BA, Hofmann J, Zelger BG, Hautz T, Resch T, Margreiter C, Maglione M, Komlódi T, Ulmer H, Cardini B, Troppmair J, Öfner D, Gnaiger E, Schneeberger S, Oberhuber R (2024) The predictive value of graft viability and bioenergetics testing towards the outcome in liver transplantation. Transpl Int 37. https://doi.org/10.3389/ti.2024.12380HumanLiverIschemia-reperfusionOther
Fitzgerald 2024 J Cachexia Sarcopenia Muscle2024Fitzgerald LF, Lackey J, Moussa A, Shah SV, Castellanos AM, Khan S, Schonk M, Thome T, Salyers ZR, Jakkidi N, Kim K, Yang Q, Hepple RT, Ryan TE (2024) Chronic aryl hydrocarbon receptor activity impairs muscle mitochondrial function with tobacco smoking. https://doi.org/10.1002/jcsm.13439MouseSkeletal muscleCOPD
Abegg 2024 Toxicol Lett2024Abegg VF, Panajatovic MV, Mancuso RV, Allard JA, Duthaler U, Odermatt A, Krähenbühl S, Bouitbir J (2024) Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. https://doi.org/10.1016/j.toxlet.2024.01.008HumanLiver
Donnelly 2024 Redox Biol2024Donnelly C, Komlódi T, Cecatto C, Cardoso LHD, Compagnion A-C, Matera A, Tavernari D, Campiche O, Paolicelli RC, Zanou N, Kayser B, Gnaiger E, Place N (2024) Functional hypoxia reduces mitochondrial calcium uptake. Redox Biol 71:103037. https://doi.org/10.1016/j.redox.2024.103037Human
Mouse
Heart
Skeletal muscle
Hypoxia
Al-Sabri 2024 Sci Rep2024Al-Sabri MH, Ammar N, Korzh S, Alsehli AM, Hosseini K, Fredriksson R, Mwinyi J, Williams MJ, Boukhatmi H, Schiöth HB (2024) Fluvastatin-induced myofibrillar damage is associated with elevated ROS, and impaired fatty acid oxidation, and is preceded by mitochondrial morphological changes. https://doi.org/10.1038/s41598-024-53446-wDrosophilaSkeletal muscle
Robertson 2023 J Cell Sci2023Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, Chandel NS, Mears JA, Gama V (2023) DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. https://doi.org/10.1242/jcs.260370HumanFibroblastNeurodegenerative
Awad-Igbaria 2023 J Transl Med2023Awad-Igbaria Y, Ferreira N, Keadan A, Sakas R, Edelman D, Shamir A, Francous-Soustiel J, Palzur E (2023) HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function. https://doi.org/10.1186/s12967-023-04414-xRatNervous systemOther
Zhang 2023 Nat Commun2023Zhang Y, Fan Y, Hu H, Zhang X, Wang Z, Wu Z, Wang L, Yu X, Song X, Xiang P, Zhang X, Wang T, Tan S, Li C, Gao L, Liang X, Li S, Li N, Yue X, Ma C (2023) ZHX2 emerges as a negative regulator of mitochondrial oxidative phosphorylation during acute liver injury. https://doi.org/10.1038/s41467-023-43439-0MouseLiver
Szulik 2023 Basic Res Cardiol2023Szulik MW, Valdez S, Walsh M, Davis K, Bia R, Horiuchi E, O'Very S, Laxman AK, Sandaklie-Nicolova L, Eberhardt DR, Durrant JR, Sheikh H, Hickenlooper S, Creed M, Brady C, Miller M, Wang L, Garcia-Llana J, Tracy C, Drakos SG, Funai K, Chaudhuri D, Boudina S, Franklin S (2023) SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation. https://doi.org/10.1007/s00395-023-00991-6MouseHeartCardiovascular
Mayayo-Vallverdu 2023 Redox Biol2023Mayayo-Vallverdú C, López de Heredia M, Prat E, González L, Espino Guarch M, Vilches C, Muñoz L, Asensi MA, Serra C, Llebaria A, Casado M, Artuch R, Garrabou G, Garcia-Roves PM, Pallardó FV, Nunes V (2023) The antioxidant l-Ergothioneine prevents cystine lithiasis in the Slc7a9-/- mouse model of cystinuria. https://doi.org/10.1016/j.redox.2023.102801MouseKidneyOther
Koizumi 2023 Front Cardiovasc Med2023Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T (2023) Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats. Front Cardiovasc Med 10: 1005408.RatHeartCardiovascular
Diabetes
Garcia-Roche 2023 PLoS One2023García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Cassina A, Quijano C, Carriquiry M (2023) Hepatic metabolism of grazing cows of two Holstein strains under two feeding strategies with different levels of pasture inclusion. https://doi.org/10.1371/journal.pone.0290551BovinesLiver
Airik 2023 Antioxidants (Basel)2023Airik M, Arbore H, Childs E, Huynh AB, Phua YL, Chen CW, Aird K, Bharathi S, Zhang B, Conlon P, Kmoch S, Kidd K, Bleyer AJ, Vockley J, Goetzman E, Wipf P, Airik R (2023) Mitochondrial ROS triggers KIN pathogenesis in FAN1-deficient kidneys. https://doi.org/10.3390/antiox12040900HumanKidneyOxidative stress;RONSInherited
Sharma 2023 Biosci Biotechnol Biochem2023Sharma S, Zhang X, Azhar G, Patyal P, Verma A, Kc G, Wei JY (2023) Valine improves mitochondrial function and protects against oxidative stress. https://doi.org/10.1093/bbb/zbad169MouseSkeletal muscleOxidative stress;RONS
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Menail 2023 FASEB J2023Menail HA, Cormier SB, Léger A, Robichaud S, Hebert-Chatelain E, Lamarre SG, Pichaud N (2023) Age-related flexibility of energetic metabolism in the honey bee Apis mellifera. https://doi.org/10.1096/fj.202300654rHexapodsAging;senescence
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Erdem 2022 Nat Commun2022Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhäuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ (2022) Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. https://doi.org/10.1038/s41467-022-29639-0HumanOther cell linesCancer
Bellissimo 2022 MitoFit2022Bellissimo CA, Sondergaard S, Hughes MC, Ramos SV, Larsen S, Perry CGR (2022) The influence of adenylate cycling on mitochondrial calcium-induced permeability transition pore in permeabilized skeletal muscle fibres. https://doi.org/10.26124/mitofit:2022-00262023-02-20 published in Bioenerg Commun 2023.1.MouseSkeletal musclePermeability transition
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Damgaard 2022 iScience2022Damgaard MV, Nielsen TS, Basse AL, Chubanava S, Trost K, Moritz T, Dellinger RW, Larsen S, Treebak JT (2022) Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity. https://doi.org/10.1016/j.isci.2022.103863MouseSkeletal muscle
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Siow 2022 J Cell Sci2022Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F, Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K (2022) Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. https://doi.org/10.1242/jcs.259455MouseLiverCancer
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Schumann 2021 Commun Biol2021Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826.MouseLiverDiabetes
Zuccarelli 2021 J Physiol2021Zuccarelli L, Baldassarre G, Magnesa B, Degano C, Comelli M, Gasparini M, Manferdelli G, Marzorati M, Mavelli I, Pilotto A, Porcelli S, Rasica L, Šimunič B, Pišot R, Narici M, Grassi B (2021) Peripheral impairments of oxidative metabolism after a 10-day bed rest are upstream of mitochondrial respiration. J Physiol 599:4813-29.HumanSkeletal muscle
Zweck 2021 Diabetes Care2021Zweck E, Scheiber D, Jelenik T, Bönner F, Horn P, Pesta D, Schultheiss HP, Boeken U, Akhyari P, Lichtenberg A, Kelm M, Roden M, Westenfeld R, Szendroedi J (2021) Exposure to type 2 diabetes provokes mitochondrial impairment in apparently healthy human hearts. Diabetes Care 44:e82-e84.HumanHeartDiabetes
Figueira 2021 Arch Biochem Biophys2021Figueira TR, Francisco A, Ronchi JA, Dos Santos GRRM, Santos WD, Treberg JR, Castilho RF (2021) NADPH supply and the contribution of NAD(P)+ transhydrogenase (NNT) to H2O2 balance in skeletal muscle mitochondria. Arch Biochem Biophys 707:108934.MouseSkeletal muscleOxidative stress;RONS
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Peruzzotti-Jametti 2021 PLoS Biol2021Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166.MouseNervous system
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Mazzoli 2021 Nutrients2021Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370.RatLiver
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Lelcu 2021 Children (Basel)2021Lelcu T, Bînă AM, Dănilă MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. https://doi.org/10.3390/children8121196HumanPlateletCancer
Christiansen 2021 Sci Rep2021Christiansen LB, Dohlmann TL, Ludvigsen TP, Parfieniuk E, Ciborowski M, Szczerbinski L, Kretowski A, Desler C, Tiano L, Orlando P, Martinussen T, Olsen LH, Larsen S (2021) Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected. Sci Rep 11:2167.PigHeart
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Goldberg 2021 Biochem J2021Goldberg EJ, Buddo KA, McLaughlin KL, Fernandez RF, Pereyra AS, Psaltis CE, Lin CT, Hagen JT, Boykov IN, Nguyen TK, Gowdy KM, Ellis JM, Neufer PD, McClung JM, Fisher-Wellman KH (2021) Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform. Biochem J 476:1521-37.MouseHeart
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Avram 2021 Life (Basel)2021Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288.HumanPlateletDiabetes
Jasz 2021 J Cell Mol Med2021Jász DK, Szilágyi ÁL, Tuboly E, Baráth B, Márton AR, Varga P, Varga G, Érces D, Mohácsi Á, Szabó A, Bozó R, Gömöri K, Görbe A, Boros M, Hartmann P (2021) Reduction in hypoxia-reoxygenation-induced myocardial mitochondrial damage with exogenous methane. https://doi.org/10.1111/jcmm.16498RatHeartIschemia-reperfusion
Vandenberg 2021 Neurochem Int2021Vandenberg GG, Dawson NJ, Head A, Scott GR, Scott AL (2021) Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model. Neurochem Int 146:105036.MouseNervous systemAutism
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Flensted-Jensen 2021 Free Radic Biol Med2021Flensted-Jensen M, Gram M, Dela F, Helge JW, Larsen S (2021) Six weeks of high intensity cycle training reduces H2O2 emission and increases antioxidant protein levels in obese adults with risk factors for type 2 diabetes. Free Radic Biol Med 173:1-6.HumanSkeletal muscleObesity
Antico 2021 Sci Adv2021Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK (2021) Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Sci Adv 7:eabj0722.MouseNervous system
Baldini 2021 Life Sci2021Baldini F, Fabbri R, Eberhagen C, Voci A, Portincasa P, Zischka H, Vergani L (2021) Adipocyte hypertrophy parallels alterations of mitochondrial status in a cell model for adipose tissue dysfunction in obesity. Life Sci 265:118812.MouseFibroblastObesity
Watt 2021 Nat Commun2021Watt KI, Henstridge DC, Ziemann M, Sim CB, Montgomery MK, Samocha-Bonet D, Parker BL, Dodd GT, Bond ST, Salmi TM, Lee RS, Thomson RE, Hagg A, Davey JR, Qian H, Koopman R, El-Osta A, Greenfield JR, Watt MJ, Febbraio MA, Drew BG, Cox AG, Porrello ER, Harvey KF, Gregorevic P (2021) Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nat Commun 12:2887.MouseSkeletal muscleObesity
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Hoppel 2021 Cells2021Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088HumanPlatelet
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Cai 2021 Free Radic Biol Med2021Cai H, Bian X, Chen L, Zhang N, Li L, Tang W, Liu X, Li Z (2021) Selective intra-arterial brain cooling induces cerebral protection against ischemia/reperfusion injury through SENP1-Sirt3 signaling. Free Radic Biol Med 171:272-83.MouseNervous systemOxidative stress;RONS
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Flockhart 2021 Cell Metab2021Flockhart M, Nilsson LC, Tais S, Ekblom B, Apro W, Larsen FJ (2021) Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab 33:957-70.HumanSkeletal muscle
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Marrocco 2021 J Immunol2021Marrocco A, Frawley K, Pearce LL, Peterson J, O'Brien JP, Mullett SJ, Wendell SG, St Croix CM, Mischler SE, Ortiz LA (2021) Metabolic adaptation of macrophages as mechanism of defense against crystalline silica. J Immunol 207:1627-40.MouseMacrophage-derivedOther
Klepinina 2021 PLoS One2021Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.HumanEndothelial;epithelial;mesothelial cellCancer
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Mazzoli 2021 Antioxidants (Basel)2021Mazzoli A, Spagnuolo MS, Nazzaro M, Gatto C, Iossa S, Cigliano L (2021) Fructose removal from the diet reverses inflammation, mitochondrial dysfunction, and oxidative stress in hippocampus. Antioxidants (Basel) 10:487.RatNervous system
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Gomez-Valades 2021 Cell Metab2021Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9.MouseNervous system
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Terwilliger 2021 Vasc Med2021Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58.HumanSkeletal muscleCardiovascular
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Jimenez-Uribe 2021 Free Radic Biol Med2021Jimenez-Uribe AP, Bellido B, Aparicio-Trejo OE, Tapia E, Sanchez-Lozada LG, Hernandez-Santos JA, Fernandez-Valverde F, Hernandez-Cruz EY, Orozco-Ibarra M, Pedraza-Chaverri J (2021) Temporal characterization of mitochondrial impairment in the unilateral ureteral obstruction model in rats. Free Radic Biol Med 172:358-71.RatKidneyOther
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Tungtur 2021 Sci Rep2021Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051.MouseNervous systemNeurodegenerative
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MiPNet21.17 BloodCellsIsolation2020-10-22
O2k-Protocols
O2k-Protocols: Isolation of blood cells for HRR.
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Grewal 2020 Exp Neurol2020Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248.HumanNeuroblastomaAging;senescence
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Xiong 2020 Biomed Pharmacother2020Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218.Human
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Al-Azab 2020 FEBS J2020Al-Azab M, Qaed E, Ouyang X, Elkhider A, Walana W, Li H, Li W, Tang Y, Adlat S, Wei J, Wang B, Li X (2020) TL1A/TNFR2-mediated mitochondrial dysfunction of fibroblast-like synoviocytes increases inflammatory response in patients with rheumatoid arthritis via reactive oxygen species generation. FEBS J 287:3088-104.HumanOther cell linesOther
Burtscher 2020 eNeuro2020Burtscher J, Copin JC, Sandi C, Lashuel HA (2020) Pronounced α-synuclein pathology in a seeding-based mouse model is not sufficient to induce mitochondrial respiration deficits in the striatum and amygdala. eNeuro 7:ENEURO.0110-20.2020.MouseNervous systemParkinson's
Irion 2020 Stem Cells Int2020Irion CI, Martins EL, Christie MLA, de Andrade CBV, de Moraes ACN, Ferreira RP, Pimentel CF, Suhett GD, Campos de Carvalho AC, Lindoso RS, Vieyra A, Galina A, Goldenberg RCS (2020) Acute myocardial infarction reduces respiration in rat cardiac fibers, despite adipose tissue mesenchymal stromal cell transplant. Stem Cells Int 2020:4327965 .RatHeartCardiovascular
Vanweert 2020 J Clin Endocrinol Metab2020Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab 106:e1827-36.HumanSkeletal muscleDiabetes
Szibor 2020 J Cell Mol Med2020Szibor M, Schreckenberg R, Gizatullina Z, Dufour E, Wiesnet M, Dhandapani PK, Debska-Vielhaber G, Heidler J, Wittig I, Nyman TA, Gaertner U, Hall AR, Pell V, Viscomi C, Krieg T, Murphy MP, Braun T, Gellerich FN, Schlueter KD, Jacobs HT(2020) Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia. J Cell Mol Med 24:3534-48.MouseHeartIschemia-reperfusion
Matsuo 2020 Am J Physiol Endocrinol Metab2020Matsuo FS, Araújo PHC, Mota RF, Carvalho AJR, Queiroz MS, Almeida BB, Ferreira KCOS, Metzner RJM, Ferrari GD, Alberici LC, Osako MK (2020) RANKL induces beige adipocyte differentiation in preadipocytes. Am J Physiol Endocrinol Metab 318:E866-77.MouseFatDiabetes
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Parker 2020 Thesis2020Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31.HumanBlood cellsDiabetes
Groennebaek 2020 Cells2020Groennebaek T, Billeskov TB, Schytz CT, Jespersen NR, Bøtker HE, Olsen RKJ, Eldrup N, Nielsen J, Farup J, De Paoli FV, Vissing K (2020) Mitochondrial structure and function in the metabolic myopathy accompanying patients with critical limb ischemia. Cells 9:E570.HumanSkeletal muscleIschemia-reperfusionMyopathy
Hoffmann 2020 J Clin Endocrinol Metab2020Hoffmann C, Schneeweiss P, Randrianarisoa E, Schnauder G, Kappler L, Machann J, Schick F, Fritsche A, Heni M, Birkenfeld A, Niess AM, Häring HU, Weigert C, Moller A (2020) Response of mitochondrial respiration in adipose tissue and muscle to 8 weeks of endurance exercise in obese subjects. J Clin Endocrinol Metab 105:dgaa571.HumanSkeletal muscleObesity
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Yurre 2020 Arq Bras Cardiol2020Yurre AR, Silva JDFD, Torres MKDS, Martins EL, Ramos IP, Silva WSFLD, Sarpa JDS, Guedes CCDS, Napoleão TH, Coelho LCBB, Paiva PMG, Medei E (2020) Evaluation of the cardiac effects of a water-soluble lectin (Wsmol) from Moringa oleifera seeds. Arq Bras Cardiol 114:1029-37.MouseHeart
Silva-Rodrigues 2020 Free Radic Biol Med2020Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806.RatNervous systemOxidative stress;RONSDiabetes
Cassereau 2020 Exp Neurol2020Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069.HumanFibroblastOxidative stress;RONSNeurodegenerative
Rebane-Klemm 2020 Cancers (Basel)2020Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.HumanEndothelial;epithelial;mesothelial cellCancer
Vega 2020 Physiol Rep2020Vega RB, Brouwers B, Parsons SA, Stephens NA, Pino MF, Hodges A, Yi F, Yu G, Pratley RE, Smith SR, Sparks LM (2020) An improvement in skeletal muscle mitochondrial capacity with short-term aerobic training is associated with changes in Tribbles 1 expression. Physiol Rep 8:e14416.HumanSkeletal muscle
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Courtes 2020 Brain Res Bull2020Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39.RatNervous systemOther
Charles 2020 Nanomedicine (Lond)2020Charles C, Cohen-Erez I, Kazaoka B, Melnikov O, Stein DE, Sensenig R, Rapaport H, Orynbayeva Z (2020) Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes. Nanomedicine (Lond) 15:2917-32.HumanEndothelial;epithelial;mesothelial cell
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Krajcova 2020 PLOS ONE2020Krajčová A, Urban T, Megvinet D, Waldauf P, Balík M, Hlavička J, Budera P, Janoušek L, Pokorná E, Duška F (2020) High resolution respirometry to assess function of mitochondria in native homogenates of human heart muscle. PLOS ONE 15:e0226142.HumanHeartCryopreservation
Tichanek 2020 Sci Rep2020Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418.MouseNervous systemNeurodegenerative
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McCommis 2020 Nat Metab2020McCommis KS, Kovacs A, Weinheimer CJ, Shew TM, Koves TR, Ilkayeva OR, Kamm DR, Pyles KD, King MT, Veech RL, DeBosch BJ, Muoio DM, Gross RW, Finck BN (2020) Nutritional modulation of heart failure in mitochondrial pyruvate carrier-deficient mice. Nat Metab 2:1232-47. https://doi.org/10.1038/s42255-020-00296-1MouseHeartCardiovascular
Cornelissen 2020 Hum Mol Genet2020Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106.HumanFibroblastCell death
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Ferreira 2020 PLoS Genet2020Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604.MouseLiverMitochondrial diseaseInfectious
Bhaskaran 2020 Aging Cell2020Bhaskaran S, Pollock N, C Macpherson P, Ahn B, Piekarz KM, Staunton CA, Brown JL, Qaisar R, Vasilaki A, Richardson A, McArdle A, Jackson MJ, Brooks SV, Van Remmen H (2020) Neuron-specific deletion of CuZnSOD leads to an advanced sarcopenic phenotype in older mice. Aging Cell 19:e13225.MouseSkeletal muscleAging;senescence
Baggio 2020 Neurotoxicology2020Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160.ZebrafishNervous systemOther
Keller 2020 Oxid Med Cell Longev2020Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629.HumanEndothelial;epithelial;mesothelial cellOxidative stress;RONSDiabetes
Song 2020 Obes Facts2020Song K, Zhang Y, Ga Q, Bai Z, Ge RL (2020) Increased insulin sensitivity by high-altitude hypoxia in mice with high-fat diet-induced obesity is associated with activated AMPK signaling and subsequently enhanced mitochondrial biogenesis in skeletal muscles. Obes Facts 13:455-72.Skeletal muscleHypoxiaObesity
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Garcia 2020 Mol Hum Reprod2020Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod 26:938-52.MouseLiverDiabetes
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Ehrlicher 2020 FASEB J2020Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18.MouseSkeletal muscle
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Belosludtsev 2020 Biochimie2020Belosludtsev KN, Belosludtseva NV, Kosareva EA, Talanov EY, Gudkov SV, Dubinin MV (2020) Itaconic acid impairs the mitochondrial function by the inhibition of complexes II and IV and induction of the permeability transition pore opening in rat liver mitochondria. Biochimie 176:150-57.RatLiver
Thome 2020 JCI Insight2020Thome T, Kumar RA, Burke SK, Khattri RB, Salyers ZR, Kelley RC, Coleman MD, Christou DD, Hepple RT, Scali ST, Ferreira LF, Ryan TE (2020) Impaired muscle mitochondrial energetics is associated with uremic metabolite accumulation in chronic kidney disease. JCI Insight 6:e139826.MouseSkeletal muscleMyopathy
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Cruz 2020 Drug Alcohol Depend2020Cruz JV, Maba IK, Correia D, Kaziuk FD, Cadena SMSC, Zampronio AR (2020) Intermittent binge-like ethanol exposure during adolescence attenuates the febrile response by reducing brown adipose tissue thermogenesis in rats. Drug Alcohol Depend 209:107904.RatFat
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Dirks 2020 J Physiol2020Dirks ML, Miotto PM, Goossens GH, Senden JM, Petrick HL, van Kranenburg J, van Loon LJC, Holloway GP (2020) Short-term bed rest-induced insulin resistance cannot be explained by increased mitochondrial H2O2 emission. J Physiol 598:123-37.HumanSkeletal muscleOxidative stress;RONS
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Severo 2020 Life Sci2020Severo L, Godinho D, Machado F, Hartmann D, Fighera MR, Soares FA, Furian AF, Oliveira MS, Royes LF (2020) The role of mitochondrial bioenergetics and oxidative stress in depressive behavior in recurrent concussion model in mice. Life Sci 257:117991.MouseNervous systemOther
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Weber 2020 FASEB J2020Weber M, Mera P, Casas J, Salvador J, Rodríguez A, Alonso S, Sebastián D, Soler-Vázquez MC, Montironi C, Recalde S, Fucho R, Calderón-Domínguez M, Mir JF, Bartrons R, Escola-Gil JC, Sánchez-Infantes D, Zorzano A, Llorente-Cortes V, Casals N, Valentí V, Frühbeck G, Herrero L, Serra D (2020) Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 34:11816-37.MouseLiverObesity
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Battaglia 2020 Cell Death Dis2020Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM (2020) Corticotropin-releasing hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. Cell Death Dis 11:1004.RatNervous system
Guo 2020 Hum Gene Ther2020Guo Y, Zhang K, Gao X, Zhou Z, Liu Z, Yang K, Huang K, Yang Q, Long Q (2020) Sustained oligomycin sensitivity conferring protein expression in cardiomyocytes protects against cardiac hypertrophy induced by pressure-overload via improving mitochondrial function. Hum Gene Ther 31:1178-89.MouseHeart
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Schoepf 2020 Nat Commun2020Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5HumanGenital
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Cancer
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Permeability transitionInherited
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Diabetes
Rodriguez de Yurre 2020 An Acad Bras Cienc2020Rodriguez de Yurre A, Martins EGL, Lopez-Alarcon M, Cabral B, Vera N, Lopes JA, Galina A, Takiya CM, Lindoso RS, Vieyra A, SÁenz OC, Medei E (2020) Type 2 diabetes mellitus alters cardiac mitochondrial content and function in a non-obese mice model. An Acad Bras Cienc 92:e20191340.MouseHeartDiabetes
Jayakumari 2020 J Diabetes2020Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55.HumanHeartDiabetes
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Labels:




Regulation: Coupling efficiency;uncoupling  Coupling state: LEAK, OXPHOS 

HRR: Theory 



MitoPedia concepts: Respiratory control ratio, Ergodynamics 


MitoPedia methods: Respirometry